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Cadmium absorption and retention by rats fed durum wheat (Triticum turgidum L. var. durum) grain*

Published online by Cambridge University Press:  01 August 2008

W. A. House ,
J. J. Hart ,
W. A. Norvell  and
R. M. Welch
W. A. House
Affiliation:
USDA-ARS, Plant, Soil and Nutrition Laboratory, Cornell University, Ithaca, NY 14853, USA
J. J. Hart
Affiliation:
USDA-ARS, Plant, Soil and Nutrition Laboratory, Cornell University, Ithaca, NY 14853, USA
W. A. Norvell
Affiliation:
USDA-ARS, Plant, Soil and Nutrition Laboratory, Cornell University, Ithaca, NY 14853, USA
R. M. Welch*
Affiliation:
USDA-ARS, Plant, Soil and Nutrition Laboratory, Cornell University, Ithaca, NY 14853, USA
*
†Corresponding Author: Dr Ross Welch, fax +1 607 255 2459, email RMW1@cornell.edu
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Abstract

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A whole-body radioassay procedure was used to assess the retention and apparent absorption by rats of Cd in kernels of durum wheat (Triticum turgidum L. var. durum) harvested from plants grown hydroponically in 109Cd-labelled nutrient solution. Wholegrain wheat, containing 5 μmol Cd (570 μg)/kg dry weight labelled intrinsically with 109Cd, was incorporated into test meals fed to rats that had been maintained on diets containing marginally adequate, adequate or surplus levels of Zn (0·12 mmol (8 mg), 0·43 mmol (28 mg) or 1·55 mmol (101 mg) Zn/kg respectively), and either 0 or 50 g durum wheat/kg. Regardless of diet, all rats consumed about 99 % of the test meal offered. In rats fed diets without wheat, initial Cd absorption averaged 7·7, 4·6 and 2·4 % of the dose when the diet contained 0·12 mmol (8 mg), 0·43 mmol (28 mg) or 1·55 mmol (101 mg) Zn/kg diet respectively. In rats fed wheat-containing diets, initial Cd absorption averaged 3·8 and 2·6 % of the dose when dietary Zn concentration was 0·12 mmol (8 mg) and 0·43 mmol (28 mg)/kg diet respectively. The amount of Cd retained in the body at 15 d postprandial was <2 % of the dose in all rats, and decreased as Zn in the diet increased. Even at 15 d postprandial, 32 to 44 % of the Cd retained in the body was still in the gastrointestinal tract. The results show that: (1) the bioavailability to rats of Cd in wholegrain durum wheat was depressed when wholegrain wheat was part of the regular diet; (2) increased intake of dietary Zn lowered Cd absorption and retention; (3) retention of Cd in the body at 15 d postprandial from diets containing adequate Zn was <1·3 %.

Keywords

Cadmium retentionCadmium absorptionDurum wheatRats

Information

Type
Research Article
Information
British Journal of Nutrition , Volume 89 , Issue 4 , April 2003 , pp. 499 - 508
Copyright
Copyright © The Nutrition Society 2003

Footnotes

*

Mention of a trademark or proprietary product does not constitute a guarantee or warranty of the product by the US Department of Agriculture and does not imply its approval to the exclusion of other suitable products.

References

Andersen, O, Nielsen, JB & Nordberg, GF (1992) Factors affecting the intestinal uptake of cadmium from the diet. In Cadmium in the Human Environment: Toxicity and Carcinogenicity, pp. 173–187 [Nordberg, G, Herber, RFM and L, Alessio, editors]. Lyon: International Agency for Research on Cancer.Google Scholar
Berglund, M, Åkesson A, Nermell, B & Vahter, M (1994) Intestinal absorption of dietary cadmium in women is dependent on body iron stores and fiber intake. Environmental Health Perspectives 102, 1058–1066.CrossRefGoogle ScholarPubMed
Blais, A, Lecoeur, S, Milhaud, G, Tome, D & Kolf-Clauw, M (1999) Cadmium uptake and transepithelial transport in control and long-term exposed Caco-2 cells: The role of metallothionein. Toxicology and Applied Pharmacology 160, 76–85.CrossRefGoogle ScholarPubMed
Chaney, RL, Ryan, JA, Li, Y-M, Welch, RM, Reeves, PG, Brown, SL & Green, CE (1996) Phyto-availability and bio-availability in risk assessment for cadmium in agricultural environments. In Sources of Cadmium in the Environment, pp. 49–78. Paris: OECD Publ. Services.Google Scholar
CODEX Alimentarius Commission (1999) Report of the Thirty-first Session of the Codex Committee on Food Additives and Contaminants. ALINORM 99/12A. Joint FAO/WHO Food Standards Programme. Rome: Food and Agriculture Organization.Google Scholar
Crews, HM, Owen, LM, Langford, N, Fairweather-Tait, SJ, Fox, TE, Hubbard, L & Phillips, D (2000) Use of the stable isotope 106Cd for studying dietary cadmium absorption in humans. Toxicology Letters (Shannon) 112–113, 201–207.CrossRefGoogle Scholar
DIONEX (1990) Application Note 65: Analysis of Inositol Phosphates. Sunnyvale, CA: Dionex Corporation.Google Scholar
Erdman, JA & Moul, RC (1982) Mineral composition of small-grain cultivars from a uniform test plot in South Dakota. Journal of Agricultural and Food Chemistry 30, 169–174.CrossRefGoogle Scholar
Flanagan, PR, McLellan, JS, Haist, J, Cherian, MG, Chamberlain, MJ & Valberg, LS (1978) Increased dietary cadmium absorption in mice and human subjects with iron deficiency. Gastroenterology 74, 841–846.CrossRefGoogle ScholarPubMed
Fox, MRS (1988) Nutritional factors that may influence bioavailability of cadmium. Journal of Environmental Quality 17, 175–180.CrossRefGoogle Scholar
Goyer, RA (1995) Nutrition and metal toxicity. American Journal of Clinical Nutrition 61, Suppl. 3, 646S–650S.CrossRefGoogle ScholarPubMed
Hart, JJ, Welch, RM, Norvell, WA, Sullivan, LA & Kochian, LV (1998) Characterization of cadmium binding, uptake, and translocation in intact seedlings of bread and durum wheat cultivars. Plant Physiology 116, 1413–1420.CrossRefGoogle ScholarPubMed
Hoadley, JE & Cousins, RJ (1985) Effects of dietary zinc depletion and food restriction on intestinal transport of cadmium in the rat. Proceedings of the Society for Experimental Biology and Medicine 180, 296–302.CrossRefGoogle ScholarPubMed
House, WA (1999) Trace element bioavailability as exemplified by iron and zinc. Field Crop Research 60, 115–141.CrossRefGoogle Scholar
House, WA, Van Campen, DR & Welch, RM (1997) Dietary methionine status and its relation to the bioavailability to rats of zinc in corn kernels with varying methionine content. Nutrition Research 17, 65–76.CrossRefGoogle Scholar
Jackl, GA, Rambeck, WA & Kollmer, WE (1985) Retention of cadmium in organs of the rat after a single dose of labeled cadmium-3-phytate. Biological Trace Element Research 7, 69–74.CrossRefGoogle ScholarPubMed
Jacobs, RM, Jones, AOL, Fox, MRS & Fry, BE Jr (1978) Retention of dietary cadmium and the ameliorative effect of zinc, copper, and manganese in Japanese quail. Journal of Nutrition 108, 22–32.CrossRefGoogle ScholarPubMed
Jarup, L, Berglund, M, Elinder, CG, Nordberg, G & Vahter, M (1998) Health effects of cadmium exposure: a review of the literature and a risk estimate. Scandinavian Journal of Work Environment and Health 24, Suppl. 1, 1–52.Google Scholar
Kello, D, Dekanic, D & Kostial, K (1979) Influence of sex and dietary calcium on intestinal cadmium absorption in rats. Archives of Environmental Health 34, 30–33.CrossRefGoogle ScholarPubMed
Kimura, T, Itoh, N, Min, KS, Fujita, I, Muto, N & Tanaka, K (1998) Tissue accumulation of cadmium following oral administration to metallothionein-null mice. Toxicology Letters (Shannon) 99, 85–90.CrossRefGoogle ScholarPubMed
Kiyozumi, M, Miyata, K, Takahashi, Y, Mizunaga, F, Mishima, M, Noda, S, Nakagawa, M & Kojima, S (1982) Studies on poisonous metals. XI. Effects of dietary fibers on absorption of cadmium in rats. Chemical and Pharmaceutical Bulletin 33, 4494–4499.CrossRefGoogle Scholar
Kostial, K, Kello, D, Jugo, S, Rabar, I & Maljkovic, T (1978) Influence of age on metal metabolism and toxicity. Environmental Health Perspectives 25, 81–86.CrossRefGoogle ScholarPubMed
Kostial, K, Rabar, I, Blanusa, M & Simonoviv, I (1980) The effect of iron additive to milk on cadmium, mercury, and manganese absorption in rats. Environmental Research 22, 40–45.CrossRefGoogle ScholarPubMed
Lehrfeld, J (1994) HPLC separation and quantification of phytic acid and some inositol phosphates in foods: Problems and solutions. Journal of Agricultural and Food Chemistry 42, 2726–2731.CrossRefGoogle Scholar
Lind, Y, Engman, J, Jorhem, L & Glynn, AW (1997) Cadmium accumulation in the liver and kidney of mice exposed to the same weekly cadmium dose continuously or once a week. Food and Chemical Toxicology 35, 891–895.CrossRefGoogle ScholarPubMed
Lind, Y, Engman, J, Jorhem, L & Glynn, AW (1998) Accumulation of cadmium from wheat bran, sugar-beet fibre, carrots and cadmium chloride in the liver and kidneys of mice. British Journal of Nutrition 80, 205–211.CrossRefGoogle ScholarPubMed
Lind, Y & Wicklund, GA (1997) The involvement of metallothionein in the intestinal absorption of cadmium in mice. Toxicology Letters (Shannon) 91, 179–187.CrossRefGoogle ScholarPubMed
McKenna, IM, Chaney, RL, Shyy-Hwa, T, Leach, RM Jr & Williams, FM (1992) Interactions of plant zinc and plant species on the bioavailability of plant cadmium to Japanese quail fed lettuce and spinach. Environmental Research 57, 73–87.CrossRefGoogle ScholarPubMed
McLellan, JS, Flanagan, PR, Chamberlain, MJ & Valberg, LS (1978) Measurement of dietary cadmium absorption in humans. Journal of Toxicology and Environmental Health 4, 131–138.CrossRefGoogle ScholarPubMed
Mench, MJ (1998) Cadmium availability to plants in relation to major long-term changes in agronomy systems. Agricultural Ecosystems and Environment 67, 175–187.CrossRefGoogle Scholar
Micco, C, Onori, R, Miraglia, M, Gambelli, L & Brera, C (1987) Evaluation of lead, cadmium, chromium, copper and zinc by atomic absorption spectroscopy in durum wheat milling products in relation to the percentage of extraction. Food Additives and Contaminants 4, 429–436.CrossRefGoogle Scholar
National Research Council (1995) Nutrient requirements of the laboratory rat. In Nutrient Requirements of Laboratory Animals, 4th ed. pp. 11–79. Washington, DC: National Academy Press.Google Scholar
Reeves, PG & Chaney, RL (2001) Mineral status of female rats affects absorption and organ distribution of dietary cadmium derived from edible sunflower kernels (Helianthus annuus L.). Environmental Research 85, 215–225.CrossRefGoogle ScholarPubMed
Reeves, PG, Johnson, PE & Rossow, KL (1994) Absorption and organ content of cadmium from the kernels of confectionery sunflowers (Helianthus annuus) fed to male rats. Journal of Agricultural and Food Chemistry 42, 2836–2843.CrossRefGoogle Scholar
Reeves, PG, Nielsen, EJ, O'Brien-Nimens, C & Vanderpool, RA (2001) Cadmium bioavailability from edible sunflower kernels: A long-term study with men and women volunteers. Environmental Research 87, 81–91.CrossRefGoogle ScholarPubMed
Reeves, PG, Nielsen, FH & Fahey, GC Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. Journal of Nutrition 123, 1939–1951.CrossRefGoogle Scholar
Reeves, PG & Vanderpool, R (1998) Organ content and fecal excretion of cadmium in male and female rats consuming variable amounts of naturally occurring cadmium in confectionery sunflower kernels (Helianthus annuus L.). Journal of Nutritional Biochemistry 9, 636–644.CrossRefGoogle Scholar
Satarug, S, Haswell-Elkins, MR & Moore, MR (2000) Safe levels of cadmium to prevent renal toxicity in human subjects. British Journal of Nutrition 84, 791–802.CrossRefGoogle ScholarPubMed
Schäfer, L, Andersen, O & Nielsen, JB (1986) Effects of dietary factors on g.i. Cd absorption in mice. Acta Pharmacologica et Toxicologica 59, Suppl.549–552.CrossRefGoogle Scholar
Schümann, K, Elsenhans, B, Schäfer, S, Kolb, K & Forth, W (1990) Cadmium absorption and its interaction with essential transition metals. An approach to the mechanism of intestinal cadmium absorption. Toxicological and Environmental Chemistry 27, 81–90.Google Scholar
Steel, RGD & Torrie, JH (1960) Principles and Procedures of Statistics. New York: McGraw-Hill Book Co.Google Scholar
Strehlow, CD & Barltrop, D (1988) The Shipham report. An investigation into cadmium concentration and its implications for human health: 6. Health studies. Science and the Total Environment 75, 101–133.CrossRefGoogle Scholar
Vanderpool, RA & Reeves, PG (2001) Cadmium absorption in women fed processed edible sunflower kernels labeled with a stable isotope of cadmium, 113Cd. Environmental Research 87, 69–80.CrossRefGoogle ScholarPubMed
Wagner, GJ, Nulty, E & LeFevre, M (1984) Cadmium in wheat grain: its nature and fate after ingestion. Journal of Toxicology and Environmental Health 13, 979–989.CrossRefGoogle ScholarPubMed
Welch, RM & House, WA (1980) Absorption of radiocadmium and radioselenium by rats fed intrinsically and extrinsically labeled lettuce leaves. Nutrition Reports International 21, 135–145.Google Scholar
Welch, RM & House, WA (1984) Factors affecting the bioavailability of mineral nutrients in plant foods. In Crops as Sources of Nutrients for Humans, American Society of Agronomy Special Publication no. 48, pp. 37–54. Madison, WI: American Society of Agronomy.CrossRefGoogle Scholar
Welch, RM, House, WA & Van Campen, DR (1978) Availability of cadmium from lettuce leaves and cadmium sulfate to rats. Nutrition Reports International 17, 35–42.Google Scholar
Welch, RM & Norvell, WA (1999) Mechanisms of cadmium uptake, translocation and deposition in plants. In Cadmium in Soils and Plants, pp. 125–150 [McLaughlin, MJ and Singh, BR, editors]. Boston: Kluwer Academic Publishers.CrossRefGoogle Scholar
Wing, AM (1993) The effects of whole wheat, wheat bran and zinc in the diet on the absorption and accumulation of cadmium in rats. British Journal of Nutrition 69, 199–209.CrossRefGoogle ScholarPubMed
Wing, AM, Wing, K, Tidehag, P, Hallmans, G & Sjöström, R (1992) Cadmium accumulation from diets with and without wheat bran in rats with different iron status. Nutrition Research 12, 1205–1215.CrossRefGoogle Scholar
Wing, K, Wing, A, Tidehag, P, Hallmans, G, Sunzel, B & Sjöström, R (1995) The availability of iron, zinc and cadmium to rats from composite diets with different cereal grains. Nutrition Research 15, 1525–1534.CrossRefGoogle Scholar
Wolnick, KA, Fricke, FL, Capar, SG, Braude, GL, Meyer, MW, Satzger, RD & Bonnin, E (1983) Elements in major raw agricultural crops in the United States. 1. Cadmium and lead in lettuce, peanuts, potatoes, soybeans, sweet corn and wheat. Journal of Agricultural Food Chemistry 31, 1240–1244.CrossRefGoogle Scholar
World Health Organization (1989) Evaluation of Certain Food Additives and Contaminants. Report no. 776. Geneva: WHO.Google Scholar
World Health Organization (1992) Cadmium. IPCS Environmental Heath Criteria. Geneva: WHO.Google Scholar
Zook, EG, Greene, FE & Morris, ER (1970) Nutrient composition of selected wheats and wheat products. VI. Distribution of manganese, copper, nickel, zinc, magnesium, lead, tin cadmium, chromium, and selenium as determined by atomic absorption spectroscopy and colorimetry. Cereal Chemistry 47, 720–738.Google Scholar