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Visuospatial, Visuoperceptual, and Visuoconstructive Abilities in Congenital Hypothyroidism

Published online by Cambridge University Press:  15 October 2013

Nevena Simic ,
Sarah Khan  and
Joanne Rovet
Nevena Simic*
Affiliation:
Program in Neuroscience & Mental Health, The Hospital for Sick Children, Toronto, Ontario Department of Psychology, University of Toronto, Toronto, Ontario
Sarah Khan
Affiliation:
Program in Neuroscience & Mental Health, The Hospital for Sick Children, Toronto, Ontario
Joanne Rovet
Affiliation:
Program in Neuroscience & Mental Health, The Hospital for Sick Children, Toronto, Ontario Department of Psychology, University of Toronto, Toronto, Ontario Department of Pediatrics, University of Toronto, Toronto, Ontario
*
Correspondence and reprint requests to: Nevena Simic, Neurosciences & Mental Health, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario. Canada, M5G 1×8. E-mail: nevena.simic@sickkids.ca
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Abstract

Individuals with congenital hypothyroidism (CH), even those diagnosed and treated early, experience selective cognitive deficits, the most striking of which involves the visuocognitive domain. However, the range and nature of their visuocognitive disturbances is not fully understood. We assessed a range of higher-order visuocognitive abilities in 19 children and adolescents with CH and 19 age- and sex-matched typically developing peers (TD) using a battery of neuropsychological tests and a novel self-report measure of sense of direction. CH scored lower than TD on direct tests of visuocognitive function (judging line orientation, parts-to-whole localization, copying three-dimensional block towers, discriminating designs, and matching unfamiliar faces in ¾ profile-view) as well as on self-reported problems in spatial ability. Visuocognitive problems were not global as CH and TD did not differ at copying two-dimensional block designs, mentally rotating and matching abstract shapes, or at matching unfamiliar front-view faces, design features, or designs that engaged either figure-ground segregation, visual constancy, or closure. Early and concurrent thyroid stimulating hormone (TSH) levels were associated with visuocognitive ability, although attention and working memory were not. Individuals with CH exhibit selective visuocognitive weaknesses, some of which are related to early and concurrent TSH levels. (JINS, 2013, 19, 1–9)

Keywords

VisuospatialSense of directionCongenital hypothyroidismThyroid hormoneAttentionWorking memory

Information

Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 19 , Issue 10 , November 2013 , pp. 1119 - 1127
Copyright
Copyright © The International Neuropsychological Society 2013 

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References

Baas, D., Legrand, C., Samarut, J., Flamant, F. (2002). Persistence of oligodendrocyte precursor cells and altered myelination in optic nerve associated to retina degeneration in mice devoid of all thyroid hormone receptors. Proceedings of the National Academy of Sciences of the United States of America, 99, 2907–2911.CrossRefGoogle ScholarPubMed
Benton, A.L., Sivan, A.B., Hamsher, K.S., Varney, N.R., Spreen, O. (1983). Test of facial recognition. New York: Oxford University Press.Google Scholar
Berbel, P., Navarro, D., Ausó, E., Varea, E., Rodríguez, A.E., Ballesta, J.J., de Escobar, G.M. (2010). Role of late maternal thyroid hormones in cerebral cortex development: An experimental model for human prematurity. Cerebral Cortex, 20, 1462–1475.CrossRefGoogle ScholarPubMed
Blasi, V., Longaretti, R., Giovanettoni, C., Baldoli, C., Pontesilli, S., Vigone, C., Weber, G. (2009). Decreased parietal cortex activity during mental rotation in children with congenital hypothyroidism. Neuroendocrinology, 89, 56–65.CrossRefGoogle ScholarPubMed
Bruce, V., Valentine, T., Baddeley, A. (1987). The basis of the 3/4 view advantage in face recognition. Applied Cognitive Psychology, 1, 109–120.CrossRefGoogle Scholar
Delgado, A.R., Prieto, G. (1996). Sex differences in visuospatial ability: Do performance factors play such an important role? Memory & Cognition, 24, 504–510.CrossRefGoogle ScholarPubMed
Dennis, M., Francis, D.J., Cirino, P.T., Schachar, R., Barnes, M.A., Fletcher, J.M. (2009). Why IQ is not a covariate in cognitive studies of neurodevelopmental disorders. Journal of the International Neuropsychological Society, 15, 331–343.CrossRefGoogle Scholar
Donders, A.R., van der Heijden, G.J., Stijnen, T., Moons, K.G. (2006). Review: A gentle introduction to imputation of missing values. Journal of Clinical Epidemiology, 59, 1087–1091.CrossRefGoogle ScholarPubMed
Dratman, M.B., Gordon, J.T. (1996). Thyroid hormones as neurotransmitters. Thyroid, 6, 639–647.CrossRefGoogle ScholarPubMed
Epstein, R., Kanwisher, N. (1998). A cortical representation of the local visual environment. Nature, 392, 598–601.CrossRefGoogle ScholarPubMed
Farwell, A.P., Leonard, J.L. (2005). Nongenomic actions of thyroid hormone during fetal brain development. Current Opinion in Endocrinology Diabetes, 12, 17–22.CrossRefGoogle Scholar
Fuggle, P.W., Grant, D.B., Smith, I., Murphy, G. (1991). Intelligence, motor skills and behaviour at 5 years in early-treated congenital hypothyroidism. European Journal of Pediatrics, 150, 570–574.CrossRefGoogle ScholarPubMed
Galletti, C., Fattori, P., Kutz, D.F., Battaglini, P.P. (1997). Arm movement-related neurons in the visual area V6A of the macaque superior parietal lobule. The European Journal of Neuroscience, 9, 410–413.CrossRefGoogle ScholarPubMed
Gardner, M.F. (1996). TVPS-R-test of visual-perceptual skills (non-motor)-revised. San Francisco: Psychological and Educational Publications.Google Scholar
Harris, K.B., Pass, K.A. (2007). Increase in congenital hypothyroidism in New York state and in the United States. Molecular Genetics and Metabolism, 91, 268–277.CrossRefGoogle ScholarPubMed
Haugen, B.R. (2009). Drugs that suppress TSH or cause central hypothyroidism. Best Practice & Research Clinical Endocrinology & Metabolism, 23, 793–800.CrossRefGoogle ScholarPubMed
Hegarty, M., Montello, D.R., Richardson, A.E., Ishikawa, T., Lovelace, K. (2006). Spatial abilities at different scales: Individual differences in aptitude-test performance and spatial-layout learning. Intelligence, 34, 151–176.CrossRefGoogle Scholar
Hegarty, M., Richardson, A.E., Montello, D.R., Lovelace, K., Subbiah, I. (2002). Development of a self-report measure of environmental spatial ability. Intelligence, 30, 425–447.CrossRefGoogle Scholar
Hollingshead, A.B. (1975). Four factor index of social status. New Haven, CN: Yale University, Department of Sociology.Google Scholar
Kanwisher, N., McDermott, J., Chun, M.M. (1997). The fusiform face area: A module in human extrastriate cortex specialized for face perception. The Journal of Neuroscience, 17, 4302–4311.CrossRefGoogle Scholar
Kelley, M.W., Turner, J.K., Reh, T.A. (1995). Regulation of proliferation and photoreceptor differentiation in fetal human retinal cell cultures. Investigative Ophthalmology & Visual Science, 36, 1280–1289.Google ScholarPubMed
Kempers, M.J.E., van der Sluijs Veer, L., Nijhuis-van der Sanden, M.W.G., Kooistra, L., Wiedijk, B.M., Faber, I., Vulsma, T. (2006). Intellectual and motor development of young adults with congenital hypothyroidism diagnosed by neonatal screening. Journal of Clinical Endocrinology Metabolism, 91, 418–424.CrossRefGoogle ScholarPubMed
Kooistra, L., van der Meere, J.J., Vulsma, T., Kalverboer, A.F. (1996). Sustained attention problems in children with early treated congenital hypothyroidism. Acta Pædiatrica, 85, 425–429.CrossRefGoogle ScholarPubMed
Korkman, M., Kirk, U., Kemp, S. (2007). NEPSY-II: Clinical and interpretive manual. San Antonio, TX: The Psychological Corporation.Google Scholar
Kravitz, D.J., Saleem, K.S., Baker, C.I., Mishkin, M. (2011). A new neural framework for visuospatial processing. Nature Reviews. Neuroscience, 12, 217–230.CrossRefGoogle ScholarPubMed
Lanca, M., Jerskey, B.A., O'Connor, M.G. (2003). Neuropsychologic assessment of visual disorders. Neurologic Clinics, 21, 387–416.CrossRefGoogle ScholarPubMed
Laycock, R., Crewther, S.G. (2008). Towards an understanding of the role of the ‘magnocellular advantage’ in fluent reading. Neuroscience & Biobehavioral Reviews, 32, 1494–1506.CrossRefGoogle ScholarPubMed
Leneman, M., Buchanan, L., Rovet, J. (2001). Where and what visuospatial processing in adolescents with congenital hypothyroidism. Journal of the International Neuropsychological Society, 7, 556–562.CrossRefGoogle ScholarPubMed
Lorey, F.W., Cunningham, G.C. (1992). Birth prevalence of primary congenital hypothyroidism by sex and ethnicity. Human Biology, 64, 531–538.Google ScholarPubMed
Manly, T., Robertson, I.H., Anderson, V., Nimmo-Smith, I. (1999). Manual for test of everyday attention in children. London: Thames Valley Test Company.Google Scholar
Mano, T., Sakamoto, H., Fujita, K., Makino, M., Kakizawa, H., Nagata, M., Nagasaka, A. (1998). Effects of thyroid hormone on catecholamine and its metabolite concentrations in rat cardiac muscle and cerebral cortex. Thyroid, 8, 353–358.CrossRefGoogle ScholarPubMed
Martinez-Galan, J.R., Escobar del Rey, F., Morreale de Escobar, G., Santacana, M., Ruiz-Marcos, A. (2004). Hypothyroidsm alters the development of radial glial cells in the term fetal and postnatal neocortex of the rat. Developmental Brain Research, 153, 109–114.CrossRefGoogle Scholar
Rovet, J. (2002). Congenital hypothyroidism: An analysis of persisting deficits and associated factors. Child Neuropsychology, 8, 150–162.CrossRefGoogle ScholarPubMed
Rovet, J., Alvarez, M. (1996). Thyroid hormone and attention in congenital hypothyroidism. The Journal of Pediatric Endocrinology, 9, 63–66.CrossRefGoogle ScholarPubMed
Rovet, J.F. (1999a). Congenital hypothyroidism: Long-term outcome. Thyroid, 9, 741–748.CrossRefGoogle ScholarPubMed
Rovet, J.F. (1999b). Long-term neuropsychological sequelae of early-treated congenital hypothyroidism: Effects in adolescence. Acta Paediatrica Supplement, 88, 88–95.CrossRefGoogle ScholarPubMed
Rovet, J.F., Daneman, D., Bailey, J.D. (1993). Psychologic and psychoeducational consequences of thyroxine therapy for juvenile acquired hypothyroidism. The Journal of Pediatrics, 122, 543–549.CrossRefGoogle ScholarPubMed
Rovet, J.F., Hepworth, S. (2001). Attention problems in adolescents with congenital hypothyroidism: A multicomponential analysis. Journal of the International Neuropsychological Society, 7, 734–744.CrossRefGoogle ScholarPubMed
Sakata, H., Taira, M., Kusunoki, M., Murata, A., Tanaka, Y. (1997). The TINS lecture. the parietal association cortex in depth perception and visual control of hand action. Trends in Neurosciences, 20, 350–357.CrossRefGoogle ScholarPubMed
Sheslow, D., Adams, W. (2003). Wide Range Assessment of Memory and Learning Revised (WRAML-2). Administration and technical manual Wilmington, DE: Wide Range, Inc.Google Scholar
Stano, J.F. (1999). Wechsler abbreviated scale of intelligence. San Antonio, TX: Psychological Corporation.Google Scholar
Stern, T.A., Rosenbaum, J.F., Fava, M., Biederman, J., Rauch, S.L. (2008). Massachusetts general hospital comprehensive clinical psychiatry. St. Louis, MO: Mosby.Google Scholar
Tranel, D., Vianna, E., Manzel, K., Damasio, H., Grabowski, T. (2009). Neuroanatomical correlates of the benton facial recognition test and judgment of line orientation test. Journal of Clinical and Experimental Neuropsychology, 31, 219–233.CrossRefGoogle ScholarPubMed
Ungerleider, L.G., Haxby, J.V. (1994). ‘What’ and ‘where’ in the human brain. Current Opinion in Neurobiology, 4, 157–165.CrossRefGoogle ScholarPubMed
Mishkin, M., Ungerleider, L.G. (1982). Contribution of striate inputs to the visuospatial functions of parieto-preoccipital cortex in monkeys. Behavioural Brain Research, 6, 57–77.CrossRefGoogle Scholar
Willoughby, K.A., McAndrews, M.P., Rovet, J. (2013). Effects of early thyroid hormone deficiency on children's autobiographical memory performance. Journal of the International Neuropsychological Society, 19, 419–429.CrossRefGoogle ScholarPubMed
Wobbrock, J.O., Findlater, L., Gergle, D., Higgins, J.J. (2011). Proceedings of the ACM Conference on Human Factors in Computing Systems ‘11: The Aligned Rank Transform for nonparametric factorial analyses using only ANOVA procedures (pp. 143–146). Vancouver, British Columbia: ACM Press.Google Scholar