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Genetic modification of the effect of alcohol consumption on CHD

Published online by Cambridge University Press:  07 March 2007

Lisa M. Hines
Lisa M. Hines*
Affiliation:
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
*
Corresponding author: Dr Lisa M. Hines, fax + 1 617 324 0824, email lisa_hines@hms.harvard.edu
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Abstract

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The deleterious health effects of high alcohol consumption are numerous and well recognized; however, the effect of moderate alcohol consumption on overall health continues to be a debated issue. Among the more prevalent diseases in Westernized countries, epidemiological research suggests that alcohol in moderation substantially reduces the risk of CHD, while it modestly increases the risk for certain cancers, such as breast and colon cancer. Despite the overwhelming data supporting the beneficial effect of moderate alcohol consumption on the cardiovascular system, some researchers are not convinced. Sceptics argue that the reduction in risk is attributed to a favourable lifestyle factor associated with moderate alcohol consumption, or that it may be attributed to constituents of alcoholic beverages other than ethanol, such as the antioxidants in the grapes. In order to promote overall health for the general public, it is necessary to elucidate these issues. One approach is to study population differences in alcohol metabolic efficiency, which is likely to contribute to an individual's susceptibility to alcohol-associated diseases. Among the population there is substantial variability in the efficiency to metabolize alcohol. Genetic variation among the alcohol-metabolizing genes is known to produce isoenzymes with distinct kinetic properties. Studying genetic differences that potentially influence disease susceptibility among populations may provide insight into the mechanism(s) for the relationship between risk factor and disease, such as alcohol and CHD.

Keywords

Alcohol consumptionAlcohol metabolismCHD

Information

Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 63 , Issue 1 , February 2004 , pp. 73 - 79
Copyright
Copyright © The Nutrition Society 2004

References

Bell, JR Donovan, JL, Wong, R, Waterhouse, AL, German, JB, Walzem, RL & Kasim-Karakas, SE(2000) (+)-Catechin in human plasma after ingestion of a single serving of reconstituted red wine. American Journal of Clinical Nutrition 71, 103–108.CrossRefGoogle ScholarPubMed
Bosron, WF, Lumeng, L & Li, TK (1988) Genetic polymorphism of enzymes of alcohol metabolism and susceptibility to alcoholic liver disease. Molecular Aspects of Medicine 10, 147–158.CrossRefGoogle ScholarPubMed
Chen, WJ, Loh, EW, Hsu, YP, Chen, CC, Yu, JM & Cheng, ATA (1996) Alcohol-metabolizing genes and alcoholism among Taiwanese Han men. British Journal of Psychiatry 168, 762–767.CrossRefGoogle Scholar
Clevidence, BA, Reichman, ME, Judd, JT, Muesing, RA, Schatzkin, A, Schaefer, EJ, Li, Z, Jenner, J, Brown, CC, Sunkin, M, Campbell, WS & Taylor, PR (1995) Effects of alcohol consumption on lipoproteins of premenopausal women: A controlled diet study. Arteriosclerosis, Thrombosis and Vascular Biology 15, 179–184.CrossRefGoogle ScholarPubMed
Criqui, MH, Cowan, LD, Tyroler, HA, Bangdiwala, S, Heiss, G, Wallace, RB & Cohn, R (1987) Lipoproteins as mediators for the effects of alcohol consumption and cigarette smoking on cardiovascular mortality: results from the Lipid Research Clinics Follow-up Study. American Journal of Epidemiology 126, 629–637.CrossRefGoogle ScholarPubMed
Doll, R, Peto, R, Hall, E, Wheatley, K & Gray, R (1994) Mortality in relation to consumption of alcohol: 13 years' observations on male British doctors. British Medical Journal 309, 911–918.CrossRefGoogle ScholarPubMed
Dong, Y, Poellinger, L, Okret, S, Hoog, JO von Bahr-Lindstrom, H, Jornvall, H & Gustafsson, JA (1988) Regulation of gene expression of class I alcohol dehydrogenase by glucocorticoids. Proceedings of the National Academy of Sciences USA 85, 767–771.CrossRefGoogle Scholar
Dreon, DM & Krauss, RM (1996) Alcohol, lipids, and lipoproteins Alcohol and the Cardiovascular System. NIH Publication no. 96–4133 369 – 391 [Zahkari, S, Wassef, M, editors] Bethesda MD: National Institutes of HealthGoogle Scholar
Duester, G, Shean, ML, McBride, SM & Stewart, MJ (1991) Retinoic acid response element in the human alcohol dehydrogenase gene ADH3: Implications for regulation of retinoic acid synthesis. Molecular Cell Biology 11, 1638–1646.Google ScholarPubMed
Farhat, MY, Myers, AK & Ramwell, PW (1996) Alcohol, coronary artery disease, and estrogen Alcohol and the Cardiovascular System. NIH Publication no. 96–4133 647 – 661 [Zahkari, S, Wassef, M, editors]. Bethesda, MD National Institutes of Health.Google Scholar
Frankel, EN, Kanner, J, German, JB, Parks, E & Kinsella, JE (1993) Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341, 454–457.CrossRefGoogle ScholarPubMed
Frezza, M di Padova, C, Pozzato, G, Terpin, M, Baraona, E & Lieber, CS (1990) High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism. New England Journal of Medicine 322, 95–99.CrossRefGoogle ScholarPubMed
Gall, N (2001) Is wine good for your heart? A critical review. Postgraduate Medical Journal 77, 172–176.CrossRefGoogle ScholarPubMed
Galli, A, Pinaire, J, Fischer, M, Dorris, R & Crabb, DW (2001) The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. Journal of Biological Chemistry 276, 68–75.CrossRefGoogle ScholarPubMed
Gaziano, JM, Buring, JE, Breslow, JL, Goldhaber, SZ, Rosner, B VanDenburgh, M Willett, W & Hennekens, CH (1993) Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. New England Journal of Medicine 329, 1829–1834.CrossRefGoogle ScholarPubMed
Goist, KC Jr & Sutker, PB (1985) Acute alcohol intoxication and body composition in women and men. Pharmacology Biochemistry and Behaviour 22, 811–814.CrossRefGoogle ScholarPubMed
Grenett, HE, Aikens, ML, Torres, JA, Demissie, S, Tabengwa, EM, Davis, GC & Booyse, FM (1998) Ethanol transcriptionally upregulates t-PA and u-PA gene expression in cultured human endothelial cells. Alcoholism, Clinical and Experimental Research 22, 849–853.CrossRefGoogle ScholarPubMed
Grobbee, DE, Rimm, EB, Keil, U & Renaud, S (1999) Overview of health issues related to alcohol consumption. In Health Issues Related to Alcohol Consumption xii – xxvi [MacDonald, I, editors]. Oxford: Blackwell Science Ltd.Google Scholar
Gronbaek, M, Deis, A, Sorensen, TI, Becker, U, Schnohr, P & Jensen, G (1995) Mortality associated with moderate intakes of wine, beer, or spirits. British Medical Journal 310, 1165–1169.CrossRefGoogle ScholarPubMed
Haiman, CA, Hankinson, SE, Spiegelman, D, Colditz, GA, Willett, WC, Speizer, FE, Kelsey, KT & Hunter, DJ (1999) The relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer. Cancer Research 59, 1015–1020.Google ScholarPubMed
Hart, CL, Smith, GD, Hole, DJ & Hawthorne, VM (1999) Alcohol consumption and mortality from all causes, coronary heart disease, and stroke: results from a prospective cohort study of Scottish men with 21 years of follow up. British Medical Journal 318, 1725–1729.CrossRefGoogle ScholarPubMed
Hartung, GH, Foreyt, JP, Mitchell, RE, Mitchell, JG, Reeves, RS & Gotto, AM Jr (1983) Effect of alcohol intake on high-density lipoprotein cholesterol levels in runners and inactive men. Journal of the American Medical Association 249, 747–750.CrossRefGoogle ScholarPubMed
Hartung, GH, Lawrence, SJ, Reeves, RS & Foreyt, JP (1993) Effect of alcohol and exercise on postprandial lipemia and triglyceride clearance in men. Atherosclerosis 100, 33–40.CrossRefGoogle ScholarPubMed
Hashimoto, Y, Nakayama, T, Futamura, A, Omura, M, Nakarai, H & Nakahara, K (2002) Relationship between genetic polymorphisms of alcohol-metabolizing enzymes and changes in risk factors for coronary heart disease associated with alcohol consumption. Clinical Chemistry 48, 1043–1048.CrossRefGoogle ScholarPubMed
Higuchi, S, Matsushita, S, Murayama, M, Takagi, S & Hayashida, M (1995) Alcohol and aldehyde dehydrogenases polymorphisms and the risk for alcoholism. American Journal of Psychiatry 152, 1219–1221.Google ScholarPubMed
Hines, LM, Stampfer, MJ, Ma, J, Gaziano, JM, Ridker, PM, Hankinson, SE, Sacks, F, Rimm, EB & Hunter, DJ (2001) Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction. New England Journal of Medicine 344, 549–555.CrossRefGoogle ScholarPubMed
Ingelman-Sundberg, M, Ronis, MJ, Lindros, KO, Eliasson, E & Zhukov, A (1994) Ethanol-inducible cytochrome P4502E1: regulation, enzymology and molecular biology. Alcohol and Alcoholism 2, 131 –139 Suppl.Google ScholarPubMed
Kannel, WB (1988) Alcohol and cardiovascular disease. Proceedings of the Nutrition Society 47, 99–110.CrossRefGoogle ScholarPubMed
Kauhanen, J, Kaplan, GA, Goldberg, DE & Salonen, JT (1997) Beer binging and mortality: results from the Kuopio ischaemic heart disease risk factor study, a prospective population based study. British Medical Journal 315, 846–851.CrossRefGoogle ScholarPubMed
Kitamura, A, Iso, H, Sankai, T, Naito, Y, Sato, S, Kiyama, M, Okamura, T, Nakagawa, Y, Iida, M, Shimamoto, T & Komachi, Y (1998) Alcohol intake and premature coronary heart disease in urban Japanese men. American Journal of Epidemiology 147, 59–65.CrossRefGoogle ScholarPubMed
Kozararevic, D McGee, D Vojvodic, N, Racic, Z, Dawber, T, Gordon, T & Zukel, W (1980) Frequency of alcohol consumption and morbidity and mortality: The Yugoslavia Cardiovascular Disease Study. Lancet i, 613–616.CrossRefGoogle Scholar
Langer, RD, Criqui, MH & Reed, DM (1992) Lipoproteins and blood pressure as biological pathways for effect of moderate alcohol consumption on coronary heart disease. Circulation 85, 910–915.CrossRefGoogle ScholarPubMed
Lieber, CS (1999) Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968–1998) – a review. Alcoholism, Clinical and Experimental Research 23, 991–1007.Google Scholar
McCarver, DG Thomasson, HR, Martier, SS, Sokol, RJ & Li, TK (1997) Alcohol dehydrogenase-2*3 allele protects against alcohol-related birth defects among African Americans. Journal of Pharmacology and Experimental Therapeutics 283, 1095–1101.Google ScholarPubMed
Ma, J, Stampfer, MJ, Hennekens, CH, Frosst, P, Selhub, J, Horsford, J, Malinow, MR, Willett, WC & Rozen, R (1996) Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians. Circulation 94, 2410–2416.CrossRefGoogle ScholarPubMed
Meister, KA, Whelan, EM & Kava, R (2000) The health effects of moderate alcohol intake in humans: an epidemiologic review. Critical Reviews in Clinical Laboratory Sciences 37, 261–296.CrossRefGoogle ScholarPubMed
Mukamal, KJ, Conigrave, KM, Mittleman, MA, Camargo, CA Jr, Stampfer, MJ, Willett, WC & Rimm, EB (2003) Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men. New England Journal of Medicine 348, 109–118.CrossRefGoogle ScholarPubMed
Nakamura, Y, Amamoto, K, Tamaki, S, Okamura, T, Tsujita, Y, Ueno, Y, Kita, Y, Kinoshita, M & Ueshima, H (2002) Genetic variation in aldehyde dehydrogenase 2 and the effect of alcohol consumption on cholesterol levels. Atherosclerosis 164, 171–177.CrossRefGoogle ScholarPubMed
Niederhut, MS, Gibbons, BJ, Perez-Miller, S & Hurley, TD (2001) Three-dimensional structures of the three human class I alcohol dehydrogenases. Protein Science 10, 697–706.CrossRefGoogle ScholarPubMed
Osier, MV, Pakstis, AJ, Soodyall, H, Comas, D, Goldman, D, Odunsi, A, et al. (2002) A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. American Journal of Human Genetics 71, 84–99.CrossRefGoogle ScholarPubMed
Paice, AG, Hesketh, JE, Richardson, PJ & Preedy, VR (1996) The effect of starvation and ethanol on c-myc messenger RNA expression in the heart. Biochemical Society Transactions 24 212SAbstrCrossRefGoogle ScholarPubMed
Potter, JJ, Yang, VW & Mezey, E (1989) Influence of growth hormone on the synthesis of rat liver alcohol dehydrogenase in primary hepatocyte culture. Archives of Biochemistry and Biophysics 274, 548–555.CrossRefGoogle ScholarPubMed
Purohit, V (1998) Moderate alcohol consumption and estrogen levels in postmenopausal women: A review. Alcoholism, Clinical and Experimental Research 22, 994–997.CrossRefGoogle ScholarPubMed
Qulali, M, Ross, MA & Crabb, DW (1991) Estradiol induces class I alcohol dehydrogenase activity and mRNA in kidney of female rats. Archives of Biochemistry and Biophysics 288, 406–413.CrossRefGoogle Scholar
Renaud, SC, Gueguen, R, Schenker, J & d'Houtaud, A (1998) Alcohol and mortality in middle-aged men from eastern France. Epidemiology 9, 184–188.CrossRefGoogle ScholarPubMed
Rimm, EB, Klatsky, A, Grobbee, D & Stampfer, MJ (1996) Review of moderate alcohol consumption and reduced risk of coronary heart disease: Is the effect due to beer, wine, or spirits?. British Medical Journal 312, 731–736.CrossRefGoogle ScholarPubMed
Rimm, EB & Stampfer, MJ (2000) Alcohol abstinence: A risk factor for coronary artery disease Heart Disease Update Series. vol. 2. no. 3 1 – 10 Braunwald E Philadelphia, PA W.B. Saunders CompanyGoogle Scholar
Rimm, EB, Williams, P, Fosher, K, Criqui, M & Stampfer, MJ (1999) Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. British Medical Journal 319, 1523–1528.CrossRefGoogle ScholarPubMed
Rossouw, JE, Anderson, GL, Prentice, RL, LaCroix, AZ Kooperberg, C, Stefanick, ML, Jackson, RD, Beresford, SA, Howard, BV, Johnson, KC, Kotchen, JM, Ockene, J & Writing, G roup for the Women's Health Initiative Investigators (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. Journal of the American Medical Association 288, 321–333.Google ScholarPubMed
Sesso, HD & Gaziano, JM (1999) Alcohol intake and cardiovascular morbidity and mortality. Current Opinion in Nephrology and Hypertension 8, 353–357.CrossRefGoogle ScholarPubMed
Steering Committee of the Physician's Health Study Research Group (1989) Final report of the aspirin component of the ongoing physician's health study. New England Journal of Medicine 321, 129–135.CrossRefGoogle Scholar
Takeshita, T, Morimoto, K, Mao, X, Hashimoto, T & Furuyama, J (1994) Characterization of the three genotypes of low Km aldehyde dehydrogenase in a Japanese population. Human Genetics 94, 217–223.CrossRefGoogle Scholar
Teschke, R & Heymann, K (1982) Effect of sex hormones on the activities of hepatic alcohol-metabolizing enzymes in male rats. Enzyme 28, 268–277.CrossRefGoogle ScholarPubMed
Teschke, R, Wannagat, FJ, Lowendorf, F & Strohmeyer, G (1986) Hepatic alcohol metabolizing enzymes after prolonged administration of sex hormones and alcohol in female rats. Biochemical Pharmacology 35, 521–527.CrossRefGoogle ScholarPubMed
Thomasson, HR, Edenberg, HJ, Crabb, DW, Mai, XL, Jerome, RE, Li, TK, Wang, SP, Lin, YT, Lu, RB & Yin, SJ (1991) Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. American Journal of Human Genetics 48, 677–681.Google ScholarPubMed
Wenger, NK (1996) Gender differences in coronary risk and risk factors. In Prevention of Myocardial Infarction 387 – 412 [Manson, JE, Ridker, PM, Gaziano, JM, Hennekens, CH, New York Oxford: University Press.CrossRefGoogle Scholar
Whitehead, TP, Robinson, D, Allaway, S, Syms, J & Hale, A (1995) Effect of red wine ingestion on the antioxidant capacity of serum. Clinical Chemistry 41, 32–35.CrossRefGoogle ScholarPubMed
Whitfield, JB (1994) ADH and ALDH genotypes in relation to alcohol metabolic rate and sensitivity. Alcohol and Alcoholism 2 59 – 65 Suppl.Google ScholarPubMed
Whitfield, JB, O'Brien, ME, Nightingale, BN, Zhu, G, Heath, AC & Martin, NG (2003) ADH genotype does not modify the effects of alcohol on high-density lipoprotein. Alcoholism, Clinical and Experimental Research 27, 509–514.CrossRefGoogle Scholar
Yuan, JM, Ross, RK, Gao, YT, Henderson, BE & Yu, MC (1997) Follow-up study of moderate alcohol intake and mortality among middle aged men in Shanghai, China. British Medical Journal 314, 18–23.CrossRefGoogle ScholarPubMed