Highlights
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• People who reattempt suicide have greater severity across most clinical scales applied.
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• Comorbidity and non-suicidal self-harm are central in symptomatic networks.
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• The single attempt and reattempt symptomatic networks are equivalent.
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• Assessments can be adjusted to better monitor the occurrence of reattempts.
Introduction
More than 720,000 people die annually by suicide around the world [1]. The WHO has urged to implement national plans to curve the increasing trends of suicide mortality observed in some countries in recent years [Reference de la Torre-Luque, Perez-Diez, Pemau, Martinez-Ales, Borges, Perez-Sola and Ayuso-Mateos2-4].
Suicide includes a series of complex and fluctuating thoughts and behaviors, from passive ideas of death to suicide attempts and reattempts. Classical studies have intended to understand this phenomenon focusing on specific risk factors to detect and prevent suicide [Reference Baumeister5-Reference Linehan, Comtois and Ward-Ciesielski7]. Some of the most studied risk factors are impulsivity, childhood trauma, depressive symptoms, or the presence of previous suicide attempts [Reference Andreo-Jover, Ramos, Bobes, Bravo-Ortiz, Cebria and Crespo-Facorro8-Reference Zatti, Rosa, Barros, Valdivia, Calegaro and Freitas13]. Specifically, the presence of previous suicide attempts is one of the most critical risk factors for reattempts. Recent work suggests that between 20 and 30% of people who attempted suicide will do so again [Reference Goñi-Sarriés, Yárnoz-Goñi and López-Goñi14,Reference de la Torre-Luque, Pemau, Ayad-Ahmed, Borges, Fernandez-Sevillano and Garrido-Torres15].
Despite obtaining valuable data, this approach has proven limited. More recently, ideation-action models have gained relevance [Reference Joiner16-Reference O’Connor, O’Connor and Pirkis19]. These models intend to study why some people transition from suicidal ideation to suicide attempts raising the polyhedric and multicausal nature of suicide. The integrated motivational-volitional model has gained the most relevance within this approach [Reference O’Connor and Kirtley20]. This model proposes three phases in the suicidal process: pre-motivational, motivational and volitional. At first, and through variables such as defeat and entrapment, suicidal ideation would arise. Later, through the action of certain moderators, this ideation could lead to a suicide attempt. However, many gaps remain unclear about how their interaction increases the risk of suicidal behavior [Reference García-Haro, González-González, Fonseca-Pedrero, Al-Halabí, Al-Halabí and Fonseca-Pedrero21,Reference Nock and O’Connor22].
Moving from single-factor models to the ideation-action perspective, the evolution in the field of study has come hand in hand with new statistical analysis. One of the techniques introduced with promising results is Network Analysis. Network analysis used to study mental pathology arises from Borsboom’s proposal and goes beyond being a mere statistical approximation [Reference Borsboom23]. In his work, he suggested that mental pathology should be understood as a complex system, featured by the constant interaction between relevant symptoms. Recurrent interactions between symptoms can therefore be reflected by network structures. Network analysis also allows to know which symptoms are most central (more interconnected and therefore relevant) to the diagnosis studied. This way, we could better characterize the diagnoses, begin a first causal approach to the phenomena and eventually develop better treatments [Reference Roefs, Fried, Kindt, Martijn, Elzinga and Evers24]. Furthermore, the network proposal escapes the reductionism of the traditional diagnostic vision. It defies the notion of common causes of symptoms and recognizes the relevance of feedback loops in psychopathology [Reference Borsboom, Cramer and Kalis25].
Although suicide is not a diagnosis, different works have tried to bring this philosophy of analysis closer to suicidal behavior [Reference Fonseca-Pedrero, Díez-Gómez, de la Barrera, Sebastian-Enesco, Ortuño-Sierra and Montoya-Castilla26-Reference Shiratori, Tachikawa, Nemoto, Endo, Aiba, Matsui and Asada33]. To date, risk factors studied, populations and results present high variability [Reference Núñez, Ulloa, Guillaume, Olié, Alacreu-Crespo and Courtet30-Reference Shiratori, Tachikawa, Nemoto, Endo, Aiba, Matsui and Asada33]. In addition to this variability, works focused on this technique are still scarce.
Several authors raise the enormous potential of these techniques to validate complex models of suicidal behavior and to compare groups of patients by personalizing treatments [Reference García-Haro, González-González, Fonseca-Pedrero, Al-Halabí, Al-Halabí and Fonseca-Pedrero21, Reference de Beurs27]. Comparing groups of people with a single suicide attempt versus several attempts is especially promising, and it could help detect different profiles and risk factors [Reference Abascal-Peiró, Alacreu-Crespo, Peñuelas-Calvo, López-Castromán and Porras-Segovia34-Reference Pemau, Marin-Martin, Diaz-Marsa, De la Torre-Luque, Ayad-Ahmed and Gonzalez-Pinto36].
Some previous studies have approached this topic, reaching different conclusions. Nuñez et al. [Reference Núñez, Ulloa, Guillaume, Olié, Alacreu-Crespo and Courtet30] found some differences in the networks of single-attempt and reattempt groups, although not statistically significant. De Beurs et al. [Reference de Beurs, van Borkulo and O’Connor28] also found no significant differences when focusing on suicidal ideation.
To overcome some of the limitations of previous work, we searched for people who had attempted suicide recently (last 10 days). In addition, risk factors from multiple domains (motivational, volitional, cognitive, demographic, etc.) were included. Specifically, the risk factors considered were impulsivity, childhood trauma, psychiatric symptoms, previous suicidal behaviors, non-suicidal self-harm, substance use, sex, age, and acquired capability for suicide. The general symptom network was studied based on these risk factors, as well as their centrality and stability indices. Subsequently, we compared whether the network of the single attempt group and that of the reattempt group differed in their structure.
Our hypotheses are presented below. Regarding the general network, we believe that anxiety, depression, and ideation will be central nodes based on previous work [Reference Fonseca-Pedrero, Díez-Gómez, de la Barrera, Sebastian-Enesco, Ortuño-Sierra and Montoya-Castilla26,Reference de Beurs, van Borkulo and O’Connor28,Reference Núñez, Ulloa, Guillaume, Olié, Alacreu-Crespo and Courtet30]. Regarding differences between groups, we hypothesize that the symptom network will be more strongly connected in the reattempt group than in the single-attempt group. Borsboom [Reference Borsboom23] suggests that symptoms end up generating stability if they tend to occur together. We also believe that impulsivity will be more central in the reattempt group network [Reference Núñez, Ulloa, Guillaume, Olié, Alacreu-Crespo and Courtet30]. Also, the variable of acquired capability will present greater centrality in the reattempt group. The acquired capability is directly related to greater pain tolerance and knowledge of suicide methods [Reference Joiner16].
Method
Participants
For the current study, 1043 patients admitted at different hospital emergency departments due to a suicide attempt participated. The sample came from the “Suicide Prevention and Intervention Study (SURVIVE)” cohort. The SURVIVE study puts together research efforts from researchers of 10 hospitals spread across the Spanish territory. The ethical committees of all the hospitals involved approved the study. The study protocol is described in more detail elsewhere [Reference Pérez, Elices, Toll, Bobes, López-Solà and Díaz-Marsá37].
For the present work, the inclusion criteria were the following: (a) people older than 18 years, (b) attempt carried out with at least some wish to die, and (c) suicide attempt within the 10 days before the evaluation. Exclusion criteria were the following: (a) difficulties in understanding the instructions, either due to cognitive impairment or language, (b) unclear intentionality of the event, (c) medical damage after the attempt that makes it impossible to answer the questionnaires, and (d) the patient had more than 30 total lifetime attempts (considering completed, aborted and interrupted). All participants filled out the corresponding informed consent.
Data collection was performed between December 2020 and March 2023. Patient’s interviews were done by specialized mental health personnel on each recruitment site.
Participants were classified into two groups according to the existence of previous suicide attempts: a reattempt group, including people who presented completed attempts prior to the index, and a single attempt group, whose index attempt was the first.
Instruments
Socio-demographics, clinical data, and characteristics of the suicidal behavior were collected using a clinical interview.
Patients were evaluated using a structured diagnostic interview. It explores the main psychiatric disorders of the DSM-5 [38]. For the analyses, the total number of diagnoses was summed. The presence of substance abuse, both alcohol and drugs, was also considered in the analysis given the relevance of these factors in previous works [Reference Pemau, Marin-Martin, Diaz-Marsa, De la Torre-Luque, Ayad-Ahmed and Gonzalez-Pinto36].
Psychiatric symptomatology was evaluated using the Brief Symptom Inventory (BSI) [Reference Derogatis and Melisaratos39,Reference Pereda, Forns and Peró40]. It is a self-administered screening scale for psychopathology. It comprises 53 items divided into different subscales: somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobia, paranoia, and psychoticism. The Cronbach’s alpha reliability coefficient of the subscales in the Spanish version ranges between .72 < α < .84. The Spanish validation study found the same nine factor structure as the original work (using confirmatory factor analysis).
Impulsivity was evaluated using the Barrat Impulsivity Scale (BIS-11) [Reference Barratt41,Reference Oquendo, Baca-García, Graver, Morales, Montalvan and Mann42]. This is a self-administered scale of 28 questions. It allows obtaining a global impulsivity score as well as three subscales: cognitive, motor, and unplanned impulsivity. In the Spanish version, the internal consistency is around .8. The test–retest reliability after 2 months is .89. The validity parameters (factorial structure) obtained were acceptable.
Variables related to the current suicide attempt were assessed with the Columbia Suicide Rating Scale (C-SSRS) [Reference Posner, Brown, Stanley, Brent, Yershova and Oquendo43,Reference Al-Halabí, Sáiz, Burón, Garrido, Benabarre and Jiménez44]. The C-SSRS is a clinician-administered scale that evaluates different aspects of suicidal ideation and behavior. It includes aspects such as intensity of suicidal ideation, types of suicidal behavior (completed, aborted, and interrupted attempts), and lethality of said attempts. Items referring to the severity of ideation were included in the network (most severe ideation, frequency, duration, controllability). These domains were considered because recent work points out the importance of adequately characterizing suicidal ideation and recognizing different aspects of it [Reference Reeves, Vasconez and Weiss45]. However, the reasons and deterrents for ideation were not considered in the network as they are eminently qualitative [Reference Al-Halabí, Sáiz, Burón, Garrido, Benabarre and Jiménez44]. It also inquires about the presence of non-suicidal self-harm. The Spanish adaptation presents adequate convergent and divergent validity. In this version, Cronbach’s alpha was calculated only for the ideation scale, obtaining a value of .53.
Childhood maltreatment and abuse-related information was collected by using the Childhood Trauma Questionnaire (CTQ-SF) [Reference Bernstein, Fink, Handelsman and Foote46,Reference Hernandez, Gallardo-Pujol, Pereda, Arntz, Bernstein and Gaviria47]. This self-administered questionnaire consists of 28 items. It includes five subscales: sexual abuse, physical abuse, emotional abuse, physical neglect, and emotional neglect. The Cronbach’s alpha of the subscales in the Spanish sample is between .66 < α < .94 (the lowest being physical neglect). The Spanish adaptation showed good fit of the five-factor structure.
Acquired capability for suicide was assessed using the Acquired Capability for Suicide Scale Fearlessness About Death (ACSS-FAD) [Reference Ribeiro, Witte, Van Orden, Selby, Gordon and Bender48]. This is a 7-item self-administered scale, focused specifically on the lack of fear of death. The scale presented adequate convergent and discriminant validity.
Data analysis
First, descriptive analyses were performed. Subsequently, χ 2 tests were performed to compare qualitative variables between groups (single attempt and reattempt). Effect sizes were obtained using Cramer’s v. For quantitative variables, Student’s t-tests for independent samples or Mann-Whitney’s u-tests were used (in case of highly asymmetric distributions). Hedges’s g was used as a measure of the effect size in the first case and Pearson’s r in the second case. After this, the general network was estimated using all patients.
The network analysis approach was used to study the complex patterns of interactions between risk factors for suicide. Three networks were estimated: one for the complete sample, one for the single-attempt group, and one for the reattempt group. In the network, nodes represent risk factors, both demographic and clinical: age, sex, psychiatric symptomatology and diagnoses, impulsivity, suicidal ideation, childhood trauma, and acquired capability for suicide; and the edges joining the nodes represent the relationship between them once the other relationships are considered. Mixed Graphical Modeling (MGM) was used for network estimation. Networks were weighted and regularized by the Least Absolute Shrinkage and Selection Operator (LASSO).
The interpretation of networks should not be based on visual representation alone. This can lead to a misunderstanding of the relevance and relationship of the nodes. For this reason, different centrality measures are included [Reference Jones, Mair and McNally49]. Three centrality estimates are presented to describe the relevance of the different symptoms: strength, closeness, and betweenness. Strength expresses the sum of the edges of a given node. Closeness is a measure of the average shortest distance from nodes. Betweenness indicates the number of times a node is on the shortest path between two other nodes. A higher score in any of the three indices indicates greater centrality in the network. All measures are presented as standardized. The predictability index was also calculated. This index tells us how well we can predict a certain node based on the others. Gets values between 1 (completely determined node) and 0 (independent of the others) [Reference Haslbeck and Waldorp50].
Finally, network robustness was tested using bootstrapping methods [Reference Epskamp, Borsboom and Fried51]. We will consider acceptable stability to be above .5 [Reference Epskamp, Borsboom and Fried51]. Each of the three networks is accompanied by its corresponding centrality and robustness values. To test for significant differences in network strength and structure between the single-attempt group and the reattempt one, we used the Network Comparison Test (NCT). It is a permutation-based hypothesis test, that can assess the difference between two networks [Reference Van Borkulo52]. About 1000 iterations were considered for the general comparisons. In the case of comparisons between edges, we worked with 500 iterations.
The analyses were carried out using SPSS v28.0.1.1 and R software version 4.2.2 (packages dplyr, bootnet, networktools, NetworkComparisonTest, and qgraph).
Results
Table 1 shows descriptive data on the sociodemographic and health-related variables. Data are presented for all participants (n = 1043) as well as for subgroups based on number of suicide attempts: single attempt group (n = 390) vs reattempt group (n = 653).
Comparisons of sociodemographic and clinical data between the single attempt group and the reattempt group (N = 1043)
Note: Scores are presented as mean (standard deviation) for continuous variables and number (percentage) for categorical ones. χ2 is presented for categorical variables; u is presented for number of suicidal behaviors, BSI sub scores and CTQ-SF sub scores. t is presented in the rest of the variables. (*) statistically significant differences at p < .05. (**) statistically significant differences at p < .01.
ACSS-FAD, Acquired Capability for Suicide Scale Fearlessness About Death; BIS-11, Barratt impulsivity scale; BSI, Brief symptoms inventory; CTQ-SF, Childhood Trauma Questionnaire- short form. Gender was categorized as 0 = female and 1 = male. Nº of suicidal behaviors accounts for all attempts, whether completed or otherwise.
Differences were only found in two sociodemographic variables: marital status and employment status (p < .01). Regarding clinical scales, significant differences were found in all cases (p < .01) except in Non-Planning Impulsivity. The effect sizes of differences were small to medium across all factors, except for the number of suicidal behaviors being large (p < .01; r = .75) [Reference Cohen53]. The reattempt group presented greater severity in all cases.
Table 2 shows an analysis related to suicidal ideation from the C-SSRS. In summary, significant differences were found in all cases. Greater severity was more present in the reattempt group (p < .01; Cramer’s v = .13–.23). Effect sizes were small to moderate.
Comparisons of C-SSRS ideation scores between the single attempt and reattempt groups
Note: Scores are presented as number (percentage) for categorical ones (*) statistically significant differences at p < .05. (**) statistically significant differences at p < .01.
The symptomatic network of the entire sample can be seen in Figure 1(a). The centrality indices are presented below (Figure 1(b)). Considering strength, the most relevant nodes were the number of diagnoses as well as anxious symptoms and emotional abuse (followed by interpersonal sensitivity and psychotic symptoms). Closeness and betweenness pointed out the relevance of diagnoses, in addition to non-suicidal self-harm. The network had adequate edge stability (CS = .75) and strength values (CS = .67). The exact predictability values can be seen in Table S1 of the Supplementary Materials. They range between 0 (for the ACSS) and .41 (psychotic symptoms).
(a) Network displaying the relationship between Symptoms in the full sample. (b) Centrality indices of Symptoms. Edges in blue indicate positive relationship. Edges in red indicate negative relationship. Thicker edges represent stronger associations. The colors of the nodes group the scores of the CTQ, the BIS, the BSI, suicide-related behaviors, and other covariates. The gray border on the nodes reflects predictability. Subs_abuse = Does the patient have substance abuse; N_Diagnosis = number of diagnoses; N_behaviors = Total number of suicidal behaviors (completed, interrupted, and aborted attempts). CTQ (Childhood trauma Questionnaire): sex_ab = sexual abuse; phys_neg = physical negligence; phys_ab = physical abuse; emot_neg = emotional negligence; emot_ab = emotional abuse. CSS (Columbia suicide severity rating scale): SH = self-harm; Intense = most intense ideation; Freq = ideation frequency; Dur = Duration of ideation; Control = controllability of suicidal thoughts. BSI (Brief Symptoms Inventory): Somat = somatization; Sens = interpersonal sensitivity; Psy = psychoticism; Phob = phobias; Par = paranoia; OCD = obsessive-compulsive; Host = hostility; Dep = depression; Anx = anxiety. BIS (Barratt impulsivity scale): Nplan = unplanned impulsivity; Mot = motor impulsivity; Att = attentional impulsivity. ACSS (Acquired Capability for Suicide Scale Fearlessness About Death).
The reattempt group network (n = 653) (Figure 2(a)) showed a similar configuration to that of the global network. The nodes with the highest strength were anxious and obsessive-compulsive symptoms. The closeness measure shows the relevance of the number of diagnoses, anxiety, and phobic symptoms. Betweenness presented as relevant to the number of diagnoses, intensity of ideation, and depressive symptoms. The network presented an edge stability coefficient of .75 and a strength coefficient of .59, both being adequate. Predictability ranged from .1 (for the ACSS) to .38 (for psychotic symptoms).
(a) Network displaying the relationship between symptoms in the reattempt group. (b) Network displaying the relationship between symptoms in the single attempt group. (c) Centrality indices of Symptoms. Edges in blue indicate positive relationship. Edges in red indicate negative relationship. Thicker edges represent stronger associations. The colors of the nodes group the scores of the CTQ, the BIS, the BSI, suicide-related behaviors and other covariates. The gray border on the nodes reflects predictability. Subs_abuse = Does the patient have substance abuse; N_Diagnosis = number of diagnoses; N_behaviors = Total number of suicidal behaviors (completed, interrupted, and aborted attempts). CTQ (Childhood trauma Questionnaire): sex_ab = sexual abuse; phys_neg = physical negligence; phys_ab = physical abuse; emot_neg = emotional negligence; emot_ab = emotional abuse. CSS (Columbia suicide severity rating scale): SH = self-harm; Intense = most intense ideation; Freq = ideation frequency; Dur = Duration of ideation; Control = controllability of suicidal thoughts. BSI (Brief Symptoms Inventory): Somat = somatization; Sens = interpersonal sensitivity; Psy = psychoticism; Phob = phobias; Par = paranoia; OCD = obsessive-compulsive; Host = hostility; Dep = depression; Anx = anxiety. BIS (Barratt impulsivity scale): Nplan = unplanned impulsivity; Mot = motor impulsivity; Att = attentional impulsivity. ACSS = Acquired Capability for Suicide Scale Fearlessness About Death.
Finally, the network of people with one attempt (n = 390) (Figure 2(b)) showed some differences in its centrality indices. Based on strength, the most central nodes were emotional abuse and anxious symptoms. Regarding closeness, intensity and frequency of ideation as well as depressive symptoms were the most relevant nodes. Looking at betweenness, intensity of ideation, depressive symptoms, and number of diagnoses were the most relevant nodes. This network also had adequate edge stability (CS = .75) and strength indices (CS = .59). Predictability ranged from .0 (for the ACSS and the number of behaviors) to .36 (anxious symptoms and emotional abuse).
In all networks, subscales belonging to the same constructs tended to be interconnected. The symptoms presented greater density in their connections in the global network and in the reattempt group. In general terms, the trauma and acquired capability scores were quite separated from the rest.
Regarding the comparison between the networks, the network invariance test was not significant (p = .88). The global strength invariance test did not find significant differences (p = .34). Therefore, no differences were found between the networks in either structure or strength. Although no differences were found between both networks in global terms, differences between specific edges were studied. The edges between the following variables differed depending on the group: gender and age; age and emotional abuse; somatic and anxiety symptoms; emotional abuse and physical neglect; hostility and somatic symptoms; gender and obsessive symptoms; physical abuse and physical neglect and finally, frequency and control of ideation (p ranging from .001 to .049). The differences should not be overinterpreted, given the high number of comparisons made.
Figures S1, S3, and S5 (see Supplementary Material) show the bootstrapped confidence intervals of the edge weights for each of the networks. Some confidence intervals are considerably wide (even overlapping), so it would be advisable to interpret the order of the edges carefully. Figures S2, S4, and S6 (see Supplementary Material) show the average correlations of strength measure sampled with persons dropped and the original sample. They show generally good stability of node strength.
Discussion
The present work has applied the perspective of symptomatic networks to study a wide range of risk factors relevant to suicidal behavior. Previous work has already applied this analysis to suicide outcomes, but always focused on a smaller number of risk factors [Reference de Beurs27–Reference Núñez, Ulloa, Guillaume, Olié, Alacreu-Crespo and Courtet30,Reference Ordóñez-Carrasco, Sayans-Jiménez and Rojas-Tejada32,Reference Shiratori, Tachikawa, Nemoto, Endo, Aiba, Matsui and Asada33]. In addition, our study included a wide sample of the Spanish population with a recent attempt. The aim was to improve the understanding of the complex relationships between risk factors in this group of patients. Also, we sought to compare networks between people with a single suicide attempt versus several attempts.
People with more than one suicide attempt have greater severity across most clinical scales applied. Our hypotheses about the general network have been partially fulfilled. Although anxiety and depression are relevant nodes, in the present work, the most central node is the number of diagnoses, according to several indices. We could understand this as an indicator of greater severity, and it has already been addressed in previous works related to suicide risk [Reference Gili, Castellví, Vives, de la Torre-Luque, Almenara and Blasco54,Reference Wang, Liu, Li, Li and Huang55]. The other most relevant nodes were non-suicidal self-harm, anxious symptoms, and emotional abuse. These results are in line with what was found by a recent meta-analysis [Reference de la Torre-Luque, Pemau, Ayad-Ahmed, Borges, Fernandez-Sevillano and Garrido-Torres15]. The presence of non-suicidal self-harm has been postulated as a relevant risk factor, among other things, because it is understood as a way of losing the fear of pain and death [Reference Willoughby, Heffer and Hamza56]. Besides, the presence of non-suicidal self-harm is a way of regulating a deep discomfort that may have to do with psychiatric comorbidity, impulsivity, and a history of trauma in patients with multiple attempts [Reference Brereton and McGlinchey57]. Both anxious symptoms and emotional abuse have also demonstrated their relevance previously [Reference de la Torre-Luque, Pemau, Ayad-Ahmed, Borges, Fernandez-Sevillano and Garrido-Torres15, Reference De Araújo and Lara58].
Regarding subgroups’ networks, differences were expected between people with a single attempt and several attempts. The reattempt group network presents some equivalent indices to the global one, but obsessive-compulsive, phobic symptoms and intensity of ideation also appear relevant. More symptomatic nodes are central, which could once again indicate the relevance of comorbidity. The single-attempt group network showed some differences in terms of centrality indices, with ideation being more central (according to closeness and betweenness). This may be consistent with the ideation-to-action models as people could have made the transition from ideation for the first time [Reference Klonsky, Saffer and Bryan17]. Additionally, the reattempt group’s network seems more interconnected. However, the networks were not significantly different either in their structure or in their overall strength. This finding is consistent with previous work [Reference de Beurs, van Borkulo and O’Connor28,Reference Núñez, Ulloa, Guillaume, Olié, Alacreu-Crespo and Courtet30]. Both argued that the lack of differences could be because the entire sample has already attempted suicide, which could limit the variability of the results. In our work, the single attempt sample was relatively smaller and could affect the variability of the results. The integrated motivational volitional model does not propose a difference between variables in the repetition of the suicide attempt but rather a faster transition between phases [Reference O’Connor and Kirtley20].
Given the importance of the number of diagnoses in the network, and the differences in all scales, it could be argued that people with one or several attempts differ mainly in the severity of pathology. Their networks are not related to different intensities or structures, but the symptoms are more serious in the case of people who make several attempts. Similar data has been found in some previous works [Reference de la Torre-Luque, Pemau, Ayad-Ahmed, Borges, Fernandez-Sevillano and Garrido-Torres15,Reference Abascal-Peiró, Alacreu-Crespo, Peñuelas-Calvo, López-Castromán and Porras-Segovia34,Reference Pemau, Marin-Martin, Diaz-Marsa, De la Torre-Luque, Ayad-Ahmed and Gonzalez-Pinto36].
Results related to the ACSS-FAD test were unexpected. O’Connor’s model raises its relevance in the transition from ideation to suicide attempt [Reference O’Connor, O’Connor and Pirkis19]. However, it has turned out to be the least central node in all the networks. This goes against our initial hypotheses. However, the presence of non-suicidal self-harm has been relevant [Reference Willoughby, Heffer and Hamza56].
With respect to predictability, it is observable that the values are moderate-low in most cases. That is, each node is not very predictable based on others. This is especially relevant in the case of the ACSS-FAD.
The study has several limitations, which are discussed below. Data comes from a cross-sectional design preventing the establishment of causal relationships. Network analysis does not provide information on directionality or causality. However, it allows for the conceptualization of complex interrelationships between symptoms and psychosocial components.
There are differences in some clinical and demographic measures between recruiting centers. This is something to be expected given that a representative sample of the Spanish population is sought, and each region presents different socioeconomic characteristics. Also, the proposed networks are not culturally independent and must be understood contextually to their time and space [Reference Borsboom, Cramer and Kalis25].
All measures were self-reported, and some of them resulted in scores of several symptoms collapsed into a single measure, which could reduce variability [Reference Núñez, Ulloa, Guillaume, Olié, Alacreu-Crespo and Courtet30]. For the analyses, only data from participants who completed all the scales were considered; this could lead to a certain degree of self-selection in the sample, limiting generalizability.
Furthermore, we have focused our work on different variables that have been relevant in past studies (specifically, impulsivity, childhood trauma, suicidal ideation, and psychiatric symptoms). There are other relevant variables not considered that could also be relevant, thus conclusions must be limited to the variables considered.
Despite limitations, different relevant aspects can be extracted. Network analysis represents a novel and scarcely used way of approaching the suicidal phenomenon. This is an interesting approach given the multicausality and complexity of suicide [Reference García-Haro, González-González, Fonseca-Pedrero, Al-Halabí, Al-Halabí and Fonseca-Pedrero21]. It is proposed that this may be useful for clinicians, focusing treatments on the most relevant nodes of the network [Reference Roefs, Fried, Kindt, Martijn, Elzinga and Evers24].
People with several suicide attempts present more severe symptoms than people with just one. Symptom networks are not significantly different between both groups, but some nodes and edges differed in each case. The lack of differences in networks could indicate that it is necessary to thoroughly evaluate risk factors regardless of the number of previous attempts. However, differences at the node centrality in each network suggest that assessments can be adjusted to better monitor the occurrence of reattempts.
Supplementary material
The supplementary material for this article can be found at http://doi.org/10.1192/j.eurpsy.2024.1807.
Acknowledgements
The following are members of SURVIVE: Iñigo Alberdi, Margarita Alcami, Natalia Angarita, Guillermo Cano-Escalera, Fernando Corbalán, Patricia Diaz-Carracedo, Jennifer Fernández-Fernández, Eduardo Fernández-Jiménez, Verónica Fernández-Rodrígues, Ainoa García-Fernández, Adriana Garcia-Ramos, Nathalia Garrido-torres, Elvira Lara, Enrico La Spina, Clara Martínez-Cao, Marta Melero, Pablo Mola, Marta Navas, Beatriz Orgaz Álvarez, Waleska Perez-Arqueros, Iván Pérez-Diez, Pablo Reguera, Julia Rider, Jose Sanchez-Moreno, Lola Saiz, Carlos Schmidt, Elisa Seijo Zazo, Lara Suárez López, Alba Toll, Mireia Vázquez, Emma Vidal Bermejo, Eduard Vieta, Iñaki Zorrilla. The authors would like to acknowledge the support of the research participants, who helped to make this work possible.
Author contribution
All the authors contributed to this paper. Conceptualization: AP, AdlTL, CMM, MDM, VP. Methodology: AP, AdlTL. Software: AP. Formal analysis: AP. Investigation: JAJ, WAA, MCR, ICG, BCF, MAB, DJP, APT, NR, PAS, MFBO, MTBB, LJT. Resources: VP, MRV, APT, AIC, IG, AdlTL, MDM, AGP, MFBO. Data Curation: AP, AdlTL, CPG. Writing - Original Draft: AP, AdlTL, CMM, MDM. Writing – Review & Editing: AP, AdlTL, CMM, MDM, JAJ, WAA, MFBO, MTBB, MCR, ICG, AIC, BCF, MAB, ME, AGP, IG, LJT, DJP, APT, CPG, NR, MRV, PAS, VP. Visualization: AP. Supervision: AdlTL, CMM, MDM. Project administration: ME, VP. Funding acquisition: VP, MRV, APT, AIC, IG, AdlTL, MDM, AGP, MFBO. All authors were involved and approved the latest version of the manuscript.
Financial support
This study was supported by the Instituto de Salud Carlos III-FIS research grants (PI16/00187, PI19/00236, PI19/00569, PI19/00685, PI19/00941, PI19/00954, PI19/01027, PI19/01256, PI19/01484, PI20/00229, PI23/01277, PI23/00822), co-funded by the European Regional Development Fund (ERDF) “A Way to Build Europe” integrated into the Plan Nacional de I + D + I and cofinanced by the ISCIII-Subdirección General de Evaluación y confinanciado por la Unión Europea (FEDER, FSE, Next Generation EU/Plan de Recuperación Transformación y Resiliencia_PRTR); the Instituto de Salud Carlos III; the CIBER of Mental Health (CIBERSAM); and the Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement (2021 SGR 01358), CERCA Programme/Generalitat de Catalunya as well as the Fundació Clínic per la Recerca Biomèdica (Pons Bartran 2022-FRCB_PB1_2022); the Government of the Principality of Asturias (grant ref.: PCTI-2018-2022 IDI/2018/235). It was also supported by an FPU grant (FPU20/01651) from the Spanish Ministry of Universities and a Universidad Complutense de Madrid Predoctoral contract for research staff in training (CT82/20-CT83/20).
Competing interest
PAS has been a consultant to and/or has received honoraria or grants from Adamed, Alter Medica, Angelini Pharma, CIBERSAM, Ethypharm Digital Therapy, European Commission, Government of the Principality of Asturias, Instituto de Salud Carlos III, Johnson & Johnson, Lundbeck, Otsuka, Pfizer, Plan Nacional Sobre Drogas and Servier. AGP has received grants and served as a consultant, advisor, or CME speaker for the following entities: Janssen-Cilag, Lundbeck, Otsuka, Alter, Angelini, Novartis, Rovi, Takeda, the Spanish Ministry of Science and Innovation (CIBERSAM), the Ministry of Science (Carlos III Institute), the Basque Government, and the European Framework Program of Research. NR contract is co-funded by the Instituto de Salud Carlos III, with file code CD23/00088, by virtue of Resolution of the Direction of the Instituto de Salud Carlos III, O.A., M.P. of December 13, 2023, awarding the Sara Borell and “Co-funded by the European Union” Contracts. IG has received grants and has served as a consultant, advisor or CME speaker for the following entities (unrelated to the present work): ADAMED, Angelini, Casen Recordati, Esteve, Ferrer, Gedeon Richter, Janssen Cilag, Lundbeck, Lundbeck-Otsuka, Luye, SEI Healthcare, Viatris outside the submitted work. She also receives royalties from Oxford University Press, Elsevier, Editorial Médica Panamericana. The remaining authors have no conflicts to declare.
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