Cellular Mechanotransduction: Diverse Perspectives from Molecules to Tissues

doi:10.1017/CBO9781139195874

'Mechanotransduction' is the term for the ability, first described by 19th-century anatomist Julius Wolff, of living tissues to sense mechanical stress and respond by tissue remodeling. More recently, the scope of mechanotransduction has been expanded to include the sensation of stress, its translation into a biochemical signal, and the sequence of biological responses it produces. This book looks at mechanotransduction in a more restricted sense, focusing on the process of stress sensing and transducing a mechanical force into a cascade of biochemical signals. This stress has become increasingly recognized as one of the primary and essential factors controlling biological functions, ultimately affecting the function of the cells, tissues, and organs. A primary goal of this broad book is also to help define the new field of mechanomics, which attempts to describe the complete mechanical state of a biological system.

- Aa Reduce text
- Aa Enlarge text

View selected items
Save to my bookmarks
Export citations
Download PDF (zip)
Save to Kindle
Save to Dropbox
Save to Google Drive
Save content to
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to .

To save content items to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Please be advised that item(s) you selected are not available.
You are about to save
Your Kindle email address

Please provide your Kindle email.

@free.kindle.com @kindle.com (service fees apply)

By using this service, you agree that you will only keep content for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services

Contents

Frontmatter
pp i-iv
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

Contents
pp v-vi
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

Contributors
pp vii-x
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

Preface
pp xi-xii
- By Mohammad R. K. Mofrad, University of California Berkeley, Roger D. Kamm, Massachusetts Institute of Technology
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

1 - Introduction
pp 1-19
- By Roger D. Kamm, Massachusetts Institute of Technology, Mohammad R. K. Mofrad, University of California, Berkeley
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

2 - Endothelial Mechanotransduction
pp 20-60
- By Peter F. Davies, University of Pennsylvania, Brian P. Helmke, University of Virginia
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

3 - Role of the Plasma Membrane in Endothelial Cell Mechanosensation of Shear Stress
pp 61-88
- By Peter J. Butler, The Pennsylvania State University, Shu Chien, University of California, San Diego
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

4 - Mechanotransduction by Membrane-Mediated Activation of G-Protein Coupled Receptors and G-Proteins
pp 89-119
- By Yan-Liang Zhang, La Jolla Bioengineering Institute, John A. Frangos, La Jolla Bioengineering Institute, Mirianas Chachisvilis, La Jolla Bioengineering Institute
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

5 - Cellular Mechanotransduction: Interactions with the Extracellular Matrix
pp 120-160
- By Andrew D. Doyle, National Institutes of Health, Kenneth M. Yamada, National Institutes of Health
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

6 - Role of Ion Channels in Cellular Mechanotransduction – Lessons from the Vascular Endothelium
pp 161-180
- By Abdul I. Barakat, University of California, Davis, Andrea Gojova, University of California, Davis
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

7 - Toward a Modular Analysis of Cell Mechanosensing and Mechanotransduction
pp 181-195
A Manual for Cell Mechanics
- By Benjamin J. Dubin-Thaler, Cell Motion Laboratories, Inc., Michael P. Sheetz, Columbia University
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

8 - Tensegrity as a Mechanism for Integrating Molecular and Cellular Mechanotransduction Mechanisms
pp 196-219
- By Donald E. Ingber, Harvard Medical School and Children’s Hospital
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

9 - Nuclear Mechanics and Mechanotransduction
pp 220-233
- By Shinji Deguchi, Okayama University, Masaaki Sato, Tohoku University
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

10 - Microtubule Bending and Breaking in Cellular Mechanotransduction
pp 234-249
- By Andrew D. Bicek, University of Minnesota, Dominique Seetapun, University of Minnesota, David J. Odde, University of Minnesota
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

11 - A Molecular Perspective on Mechanotransduction in Focal Adhesions
pp 250-268
- By Seung E. Lee, University of California, Berkeley, Roger D. Kamm, Massachusetts Institute of Technology , Mohammad R. K. Mofrad, University of California, Berkeley
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

12 - Protein Conformational Change
pp 269-285
A Molecular Basis of Mechanotransduction
- By Gang Bao, Emory University
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

13 - Translating Mechanical Force into Discrete Biochemical Signal Changes
pp 286-338
Multimodularity Imposes Unique Properties to Mechanotransductive Proteins
- By Vesa P. Hytönen, ETH Zurich, Michael L. Smith, ETH Zurich, Viola Vogel, ETH Zurich
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

14 - Mechanotransduction through Local Autocrine Signaling
pp 339-359
- By Nikola Kojic, Harvard-MIT Division of Health Science and Technology, Daniel J. Tschumperlin, Harvard School of Public Health
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

15 - The Interaction between Fluid-Wall Shear Stress and Solid Circumferential Strain Affects Endothelial Cell Mechanobiology
pp 360-376
- By John M. Tarbell, The City College of New York
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

16 - Micro- and Nanoscale Force Techniques for Mechanotransduction
pp 377-402
- By Nathan J. Sniadecki, University of Pennsylvania, Wesley R. Legant, University of Pennsylvania, Christopher S. Chen, University of Pennsylvania
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

17 - Mechanical Regulation of Stem Cells
pp 403-416
Implications in Tissue Remodeling
- By Kyle Kurpinski, University of California, Berkeley, Randall R. R. Janairo, University of California, Berkeley, Shu Chien, University of California, San Diego, Song Li, University of California, Berkeley
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

18 - Mechanotransduction
pp 417-437
Role of Nuclear Pore Mechanics and Nucleocytoplasmic Transport
- By Christopher B. Wolf, University of California, Berkeley, Mohammad R. K. Mofrad, University of California, Berkeley
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

19 - Summary and Outlook
pp 438-444
- By Mohammad R. K. Mofrad, University of California, Berkeley , Roger D. Kamm, Massachusetts Institute of Technology
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

Index
pp 445-465
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

Plate Section
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation

Metrics

Total number of HTML views: 0

Total number of PDF views: 0 *

Loading metrics...

Total views: 0 *

Loading metrics...

* Views captured on Cambridge Core between #date#. This data will be updated every 24 hours.

Usage data cannot currently be displayed.

Why this information is here

This section outlines the accessibility features of this content - including support for screen readers, full keyboard navigation and high-contrast display options. This may not be relevant for you.

Accessibility Information

Accessibility compliance for the PDF of this book is currently unknown and may be updated in the future.

Cellular Mechanotransduction

Diverse Perspectives from Molecules to Tissues

This Book has been cited by the following publications. This list is generated based on data provided by Crossref.

Book description

Refine List

Actions for selected content:

Contents

Frontmatter
pp i-iv

Contents
pp v-vi

Contributors
pp vii-x

Preface
pp xi-xii

1 - Introduction
pp 1-19

2 - Endothelial Mechanotransduction
pp 20-60

3 - Role of the Plasma Membrane in Endothelial Cell Mechanosensation of Shear Stress
pp 61-88

4 - Mechanotransduction by Membrane-Mediated Activation of G-Protein Coupled Receptors and G-Proteins
pp 89-119

5 - Cellular Mechanotransduction: Interactions with the Extracellular Matrix
pp 120-160

6 - Role of Ion Channels in Cellular Mechanotransduction – Lessons from the Vascular Endothelium
pp 161-180

7 - Toward a Modular Analysis of Cell Mechanosensing and Mechanotransduction
pp 181-195

8 - Tensegrity as a Mechanism for Integrating Molecular and Cellular Mechanotransduction Mechanisms
pp 196-219

9 - Nuclear Mechanics and Mechanotransduction
pp 220-233

10 - Microtubule Bending and Breaking in Cellular Mechanotransduction
pp 234-249

11 - A Molecular Perspective on Mechanotransduction in Focal Adhesions
pp 250-268

12 - Protein Conformational Change
pp 269-285

13 - Translating Mechanical Force into Discrete Biochemical Signal Changes
pp 286-338

14 - Mechanotransduction through Local Autocrine Signaling
pp 339-359

15 - The Interaction between Fluid-Wall Shear Stress and Solid Circumferential Strain Affects Endothelial Cell Mechanobiology
pp 360-376

16 - Micro- and Nanoscale Force Techniques for Mechanotransduction
pp 377-402

17 - Mechanical Regulation of Stem Cells
pp 403-416

18 - Mechanotransduction
pp 417-437

19 - Summary and Outlook
pp 438-444

Index
pp 445-465

Plate Section

Metrics

Full text views

Book summary page views

Accessibility standard: Unknown

Why this information is here

Accessibility Information

Cellular Mechanotransduction

Diverse Perspectives from Molecules to Tissues

Book description

Refine List

Actions for selected content:

Save Search

Contents

Metrics

Full text views

Book summary page views

Accessibility standard: Unknown

Why this information is here

Accessibility Information