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Selenium supplementation in chronic kidney disease patients undergoing haemodialysis: a systematic review of the effects on plasma selenium, antioxidant and inflammatory markers, immunological parameters and thyroid hormones

Published online by Cambridge University Press:  25 September 2024

Pricilla de C. Trigueira Open the ORCID record for Pricilla de C. Trigueira [Opens in a new window] ,
Viviane de O. Leal ,
Barbara R. Cardoso ,
Denise Mafra ,
Marina C. Araujo  and
Milena B. Stockler-Pinto
Pricilla de C. Trigueira*
Affiliation:
Post-Graduate Program in Nutrition Sciences, Fluminense Federal University (UFF), Niterói, RJ, Brazil Post-Graduate Program in Pathology, Fluminense Federal University (UFF), Niterói, RJ, Brazil
Viviane de O. Leal
Affiliation:
Pedro Ernesto University Hospital (HUPE), University of the State of Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil
Barbara R. Cardoso
Affiliation:
Department of Nutrition, Dietetics and Food, Monash University, Melbourne, VIC, Australia Victorian Heart Institute, Monash University, Clayton, VIC, Australia
Denise Mafra
Affiliation:
Post-Graduate Program in Nutrition Sciences, Fluminense Federal University (UFF), Niterói, RJ, Brazil Post-Graduate program in Medical Sciences, Fluminense Federal University (UFF), Niterói, RJ, Brazil Post-Graduate Program in Biological Sciences-Physiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil
Marina C. Araujo
Affiliation:
Sergio Arouca National School of Public Health-Oswaldo Cruz Foundation/Ministry of Health, Rio de Janeiro, RJ, Brazil
Milena B. Stockler-Pinto
Affiliation:
Post-Graduate Program in Nutrition Sciences, Fluminense Federal University (UFF), Niterói, RJ, Brazil Post-Graduate Program in Pathology, Fluminense Federal University (UFF), Niterói, RJ, Brazil Post-Graduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói, RJ, Brazil
*
*Corresponding author: Pricilla de Castro Trigueira, email: pricillatrigueira@gmail.com
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Abstract

Selenium (Se) is a mineral with several biological functions, and studies have shown that its deficiency can be linked to many complications in patients with chronic kidney disease (CKD). This study aims to systematically review the effects of Se supplementation in patients with CKD undergoing haemodialysis (HD). This systematic review was carried out according to the PRISMA statement. Clinical trials were searched in PubMed, Lilacs, Embase, Scopus and Cochrane Library databases from inception to July 2021 and updated in July 2024. The protocol was registered on PROSPERO (CRD42021231444). Two independent reviewers performed the study screening and data extraction, and the risk of bias was evaluated using the Cochrane Collaboration tool. Thirteen studies were included in this review. Only nine studies showed results on Se levels; in all, reduced Se levels were observed before supplementation. A positive effect of supplementation on plasma Se level was demonstrated. Of the ten studies analysed, six demonstrated positive effects on antioxidant and inflammatory markers. Only one study analysed immunological parameters, showing a positive impact. From two studies that analysed thyroid hormones, only one showed positive results. All studies were classified as high risk of bias. The findings suggest that Se supplementation significantly increases plasma Se levels in these patients; however, there are still not enough studies to clarify the effects of Se supplementation on the antioxidant and inflammatory markers, immune system and thyroid hormones. Further studies are needed to elucidate the effects of Se supplementation and to provide a recommendation for patients with CKD undergoing HD.

Keywords

chronic kidney diseasedietary supplementsrenal dialysisrenal insufficiencyselenium

Information

Type
Review Article
Information
Nutrition Research Reviews , Volume 38 , Issue 1 , June 2025 , pp. 294 - 305
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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