Being obese or overweight is often associated with impaired quality of life and psychological well-being (PWB) in comparison with normal-weight people (Giuli et al., Reference Giuli2014), both in developed and developing countries. PWB is considered a very important correlate of subjective well-being in people with excess weight. The concept of PWB is based on Ryff's multidimensional model (Ryff, Reference Ryff2014), which considers well-being as eudaemonic concept, and includes six dimensions: autonomy, environmental mastery, personal growth, positive relations with others, purpose in life, and self-acceptance. Few studies have analyzed the role of specific correlates of perceived well-being in the obese and overweight Italian older population. The purpose of this study was to evaluate the role of perceived well-being in obese and overweight older adults. Our study included 124 overweight and obese older participants, aged 60 years or more, selected from patients attending the Division of Endocrinology, Department of Clinical and Molecular Sciences of Polytechnic University of Marche (Italy). As previously described (Giuli et al., Reference Giuli2014), the participants were recruited on the basis of specific inclusion/exclusion criteria, in a period of three years (January 2010–December 2012). Exclusion criteria included: (1) pituitary, thyroid, adrenal, and gonadal disorders not controlled by ongoing therapy; (2) electrolyte disorders; (3) poorly controlled diabetes mellitus (glycated haemoglobin > 8%). All participants were clinically assessed and completed a protocol of questionnaires, including: the Hospital Anxiety and Depression Scale (HADS) used to assess levels of anxiety and depression; the PWB Scales of Ryff used to assess the six dimension that constitute the well-being construct; the Health-Related Quality of Life Scale (Short Form 36-item Health Survey) used to assess quality of life; the Lubben Social Network Scale used to assess the social networks and informal social support; the Psychosocial Index (PSI) used for assessing psychological distress. The included participants were mainly women (72%) and had a mean age of 68.4 years (SD = 6.0). Sixty-four percentage of the participants reported fair or poor health. A correlation analysis (SPSS 16.0; data not shown) was carried out among the PWB-subscales and psychosocial variables, to select the ones to be included in the multiple linear regression models. Separated models were computed including each PWB-subscale as dependent variable. The analysis (see Table S1, available as supplementary material attached to the electronic version of this paper at www.journals.cambridge.org/jid_IPG) showed that Social support was a positive and significant predictor in four out of six models, with an important effect in PWB positive relations with others. Inversely, HADS Depression was negatively associated with PWB autonomy, PWB personal growth, and PWB self-acceptance. These results show the important role of psychological and social conditions in overweight and obese older participants, evaluated with PWB. We found an association between depression and some dimensions of PWB. The study by Risch et al. reported a similar result, because these authors suggested that a low level of PWB could represent a risk factor for depression (Risch et al., Reference Risch, Taeger, Brüdern and Stangier2013). Moreover, our results highlight the importance of social support in PWB. In line with those findings, previous studies documented that older persons are more vulnerable to the effects of social isolation (Giuli et al., Reference Giuli, Spazzafumo, Sirolla, Abbatecola, Lattanzio and Postacchini2012), which predicts morbidity and mortality related to obesity and other causes. Moreover, it seems that social isolation and perception of loneliness can contribute to a higher risk of disability (Giuli et al., Reference Giuli, Spazzafumo, Sirolla, Abbatecola, Lattanzio and Postacchini2012). This highlights the importance of social support as a relevant public health issue (Dickens et al., Reference Dickens, Richards, Greaves and Campbell2011). Our results also suggest that the cognitive-behavioral interventions for enhancing perceived well-being are necessary, in particular for the prevention of depressive symptoms (Risch et al., Reference Risch, Taeger, Brüdern and Stangier2013). A bio-psychological perspective should be considered a valuable component in the treatment of older people affected by endocrine diseases. In particular, the use of the Ryff's PWB model could assist with the aim of gaining or maintaining a good health status in this particular clinical population. In conclusion, we suggest that the identification of predictors for PWB could be crucial when developing interventions to improve well-being and social support for overweight and obese older people.