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Investigating the association between fish consumption, dietary patterns and selenium status in Seychellois pregnant women

Published online by Cambridge University Press:  30 August 2022

M. Wesolowska ,
M.C. Conway ,
A.J. Yeates ,
E.M. McSorley ,
J.J. Strain ,
E. van Wijngaarden ,
G.J. Myers  and
M.S. Mulhern
M. Wesolowska
Affiliation:
Nutrition Innovation Centre for Food and Health, Ulster University, Coleraine, Northern Ireland
M.C. Conway
Affiliation:
Nutrition Innovation Centre for Food and Health, Ulster University, Coleraine, Northern Ireland
A.J. Yeates
Affiliation:
Nutrition Innovation Centre for Food and Health, Ulster University, Coleraine, Northern Ireland
E.M. McSorley
Affiliation:
Nutrition Innovation Centre for Food and Health, Ulster University, Coleraine, Northern Ireland
J.J. Strain
Affiliation:
Nutrition Innovation Centre for Food and Health, Ulster University, Coleraine, Northern Ireland
E. van Wijngaarden
Affiliation:
The Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
G.J. Myers
Affiliation:
The Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
M.S. Mulhern
Affiliation:
Nutrition Innovation Centre for Food and Health, Ulster University, Coleraine, Northern Ireland
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Abstract

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Fish is a rich source of selenium (Se), a powerful antioxidant which is essential for human reproduction and child neurodevelopment(Reference Habibi1). Se deficiency has been associated with numerous pregnancy complications, demonstrating that an insufficient Se concentration can affect maternal and child health(Reference Pieczyńska and Grajeta2). According to current European recommendations, women should consume 60μg Se/d(Reference Kipp3). Inadequate Se intake and status has been reported in Europe, the United Kingdom, and the Middle East(Reference Stoffaneller and Morse4). There has been limited research to investigate the effect of fish consumption on the Se status of pregnant women, particularly those with high fish consumption. The aim of this study was to examine the relationship between dietary patterns, fish consumption, and Se status in a high fish-eating cohort of Seychellois pregnant women. A total of n = 1536 pregnant women were enrolled onto the Seychelles Child Development and Nutrition Study Cohort 2. At 28 weeks’ gestation, women provided a blood sample which was used to determine serum total Se status using ICP-MS. Food Frequency Questionnaires (FFQ) were also completed at this time to evaluate habitual dietary habits (n = 267). Principal component analysis (PCA) was used to determine dietary patterns and the varimax rotation was used to identify which food groups were most frequently consumed in each of the dietary patterns(Reference Conway5). A Fish Use Questionnaire (FUQ) was also used to assess fish intakes. In this cohort, with a mean (SD) of 8.5 (4.7) fish meals /week, the median (IQR) Se status of pregnant women at 28 weeks' gestation was 102 (92, 115) μg/L. Regression analyses, controlling for age and BMI, showed that there was a significant association between total fish intake and serum Se status ( = 0.60, P = 0.027). A total of four dietary patterns were identified, however, there were no significant associations between any dietary pattern and serum Se status. In this high fish-eating cohort, fish intake was an indicator of Se status. The serum Se concentrations during pregnancy were within the optimal range of 90–105 μg/L, which is essential for adequate Selenoprotein P expression(Reference Kipp3). The effects of prenatal selenium status on birth outcomes in this cohort need to be further investigated.

Acknowledgments

The authors gratefully acknowledge the contribution of the Child Development Study team in Seychelles, which includes nurses, nutritionists, laboratory and other support personnel. This work was supported by grants from the US National Institute of Environmental Health Sciences, the National Institutes of Health and the Government of Seychelles.

References

Habibi, et al. (2020) Nutrients 12(9), 2678.CrossRefGoogle Scholar
Pieczyńska, & Grajeta, (2015) J Trace Elem Med Biol 29, 31–38.CrossRefGoogle Scholar
Kipp, , et al. (2015) J Trace Elem Med Biol 32, 195–199.Google Scholar
Stoffaneller, & Morse, (2015) Nutrients 7(3), 1494–1537.CrossRefGoogle Scholar
Conway, et al. (2018) Nutrients 10(7) 10(7), 927.CrossRefGoogle Scholar