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Fish consumption and polyunsaturated fatty acid status of pregnant women in the Seychelles Child Development and Nutrition Study Cohort 2

Published online by Cambridge University Press:  13 May 2013

A. J. Yeates ,
M. S. Mulhern ,
E. M. McSorley ,
J. M. W. Wallace ,
G. E. Watson ,
G. J. Myers ,
E. van Wijngaarden ,
C. Shamlaye ,
J. Henderson  and
S. W. Thurston
...Show all authors
A. J. Yeates
Affiliation:
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA
M. S. Mulhern
Affiliation:
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA
E. M. McSorley
Affiliation:
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA
J. M. W. Wallace
Affiliation:
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA
G. E. Watson
Affiliation:
University of Rochester, School of Medicine and Dentistry, NY, USA
G. J. Myers
Affiliation:
University of Rochester, School of Medicine and Dentistry, NY, USA
E. van Wijngaarden
Affiliation:
University of Rochester, School of Medicine and Dentistry, NY, USA
C. Shamlaye
Affiliation:
Ministry of Health, Victoria, Mahé, Republic of Seychelles
J. Henderson
Affiliation:
Ministry of Health, Victoria, Mahé, Republic of Seychelles
S. W. Thurston
Affiliation:
University of Rochester, School of Medicine and Dentistry, NY, USA
P. W. Davidson
Affiliation:
University of Rochester, School of Medicine and Dentistry, NY, USA
J. J. Strain
Affiliation:
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA
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Abstract

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Fish is the major dietary source of long chain polyunsaturated fatty acids (PUFA), including docosahexaenoic acid (DHA), which is essential for optimal child neurodevelopment( Reference Carlson and Neuringer 1 ). In the first nutrition cohort of the Seychelles Child Development Study (SCDS), we showed no significant relationship between fish consumption (average 12 meals per week) and DHA status of pregnant women( Reference Bonham, Duffy and Wallace 2 ). We hypothesised that altered fatty acid metabolism during pregnancy could be obscuring any correlation between dietary intake data and physiological measures. In the present study, we repeated the analysis to look at associations between fish consumption and PUFA status in the larger second nutrition SCDS cohort.

Fish consumption was assessed as frequency of fish meals consumed per week using a fish use questionnaire (FUQ) administered during pregnancy. Lipid extractions were carried out on serum samples collected at 28 weeks gestation following the Folch et al. method( Reference Folch, Lees and Stanley 3 ) and fatty acid methyl esters were determined by GC-MS, as previously described( Reference Bonham, Duffy and Wallace 2 ). A total of n=1474 women completed the FUQ and provided a blood sample for PUFA measurement. Descriptive statistics and Pearson correlation analysis was carried out using IBM SPSS Statistics v. 20.

* Values were significantly correlated with fish meals per week in Pearson correlation (P<0.05)

The mean age of pregnant women at enrolment to the study was 26 (SD=6) years and the mean number of fish meals consumed per week during pregnancy was reported as 8.59 (SD=4.58). Fish consumption was not significantly correlated with either individual or summed concentrations of n-3 or n-6 PUFA; however it was significantly negatively associated with the ratio of n-6:n-3 (r=−0.06, P=0.04).

These results agree with those of a previous SCDS cohort, where fish consumption, albeit assessed by food diary and in a smaller cohort (n 229)( Reference Bonham, Duffy and Wallace 2 ), was not significantly associated with serum PUFA status in pregnant women. This finding highlights a potential limitation of using fish consumption data as a biomarker for PUFA status, particularly during pregnancy. Further studies to identify a more robust biomarker for fish consumption are warranted.

References

1. Carlson, SE & Neuringer, (1999) Lipids 34, 171–178.CrossRefGoogle Scholar
2. Bonham, MP, Duffy, EM, Wallace, JMW et al. (2008) Prostag Leukotr Ess 78, 343–350.Google Scholar
3. Folch, J, Lees, M & Stanley, GH (1957) J Biol Chem 226, 497–509.Google Scholar
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