Spontaneous intracranial hypotension (SIH) is a rare condition resulting from abnormal leakage of cerebrospinal fluid (CSF). ^{Reference Beck, Ulrich and Fung1–Reference Schievink5} The exact cause of SIH remains uncertain but may be related to weakening of nerve root sheaths or minor trauma. ^{Reference Beck, Ulrich and Fung1} Recently, calcified intervertebral disc herniations (IVDH) have been recognized as a possible etiology for SIH. ^{Reference Beck, Ulrich and Fung1,Reference Thielen, Sillery and Morris6,Reference Hung and Hsu7} While these small protrusions may indeed puncture the ventral dura and result in CSF egress, their prompt recognition is frequently missed using standard imaging ^{Reference Thielen, Sillery and Morris6} and often puts the patient through nonriskless and sometimes unrevealing surgical explorations. ^{Reference Beck, Ulrich and Fung1} We report the case of a patient who acquired a traumatic CSF leak from a radiologically identified calcified IVDH piercing the dura.

A 47-year-old healthy female was referred to the outpatient clinic for a 4-week history of intermittent diplopia, photophobia and orthostatic headache which abruptly started following a minor crosscountry skiing head trauma. The positional headache was intolerable in the sitting position and completely resolved when lying down. Initial physical examination, including a complete ophthalmologic workup, and head computed tomography (CT) were completely normal. She eventually underwent a contrast-enhanced magnetic resonance imaging (MRI) of the brain which revealed diffuse pachymeningeal enhancement. Considering the high suspicion of intracranial hypotension, she underwent a blind epidural blood patch (EBP) at the L3–L4 level. EBP improved her headaches only transiently, and the patient’s symptoms progressively reoccurred within a few days. For that reason, she underwent a cervical MRI which depicted a T2-hyperintense ventral epidural collection at the T1–T2 junction highly suggestive of an anterior CSF fistula (Figure 1 A,B). Interestingly, the axial T2-weighted sequences disclosed a very focal and sharp-looking triangular T1–T2 IVDH located immediately ventral to a possible dural slit, suggesting that the dural opening likely resulted from perforation of the hernia. Moreover, a cervical CT scan unveiled a small protruding calcification which precisely matched the location of the MRI-revealed herniation (Figure 1 C,D). At that point, a traumatic CSF fistula resulting from a sharp calcified IVDH was suspected. Consequently, the patient underwent a dynamic CT myelogram which confirmed the diagnosis (Figure 2). She simultaneously underwent a targeted C7–T1 EBP which resulted in the complete resolution of her symptoms within the next few days. At the 6-month follow-up, the patient remained symptom-free.

Figure 1:

(A) Sagittal T2-weighted MRI sequences of the cervicothoracic spine revealing CSF extravasation within the anterior epidural space (arrowheads). (B) Axial T2-weighted images showing a very focal triangular T1–T2 disc herniation located on the midline and a similarly shaped triangular dural slit. The shape of the dural opening seems to be molded by the disc herniation. (C, D) Cervical (C) and axial (D) CT scan demonstrating the small focus of calcification just dorsal to the T1–T2 disc space, which corresponds precisely to the location of the disc herniation on axial MRI.

Figure 2:

CT myelogram of the cervicothoracic spine. (A, B) Reconstructed sagittal (A) and axial (B) CT myelography images showing extravasation of CSF outside the thecal sac. The arrowhead depicts the precise location of CSF egress and pinpoints the close relationship between the site of fistula and the calcified lesion.

Using conventional imaging modalities, we precisely depicted the sharp IVDH as the likely etiology of CSF fistula in the current patient. Accurately identifying the cause of spinal CSF fistula is required to guide subsequent targeted therapy. ^{Reference Thielen, Sillery and Morris6} Without the precise characterization of the nature and location of the causative lesion, therapies are often ineffective. ^{Reference Thielen, Sillery and Morris6} Blind EBP are frequently unsuccessful ^{Reference Beck, Ulrich and Fung1,Reference Thielen, Sillery and Morris6} and poorly guided surgical explorations that target the commonly false localizing epidural CSF collection may be noncontributory. ^{Reference Schievink, Maya, Jean-Pierre, Nuño, Prasad and Moser8} Thanks to the accurate radiological delineation of the calcified IVDH and the site of fistula, we were able to perform a targeted EBP which led to symptom resolution. This case reinforces the causal link of calcified IVDH in the development of intracranial hypotension, and highlights manifest imaging features that may help in the identification and concomitant management of this underrecognized pathology.