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In search of the ideal design: systematic trade-off mitigation and constraint management in optimal design synthesis

Published online by Cambridge University Press:  03 November 2025

Nökkvi S. Sigurdarson*
Affiliation:
Department of Civil and Mechanical Engineering, Technical University of Michigan Department of Mechanical Engineering , Denmark Delivery Solution Innovation, Novo Nordisk A/S , Hillerod, Denmark
Panos Y. Papalambros
Affiliation:
Department of Mechanical Engineering, University of Michigan , Ann Arbor, MI, USA
Tobias Eifler
Affiliation:
Department of Civil and Mechanical Engineering, Technical University of Michigan Department of Mechanical Engineering , Denmark
*
Corresponding author Nökkvi S. Sigurdarson nssd@novonordisk.com
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Abstract

Successful synthesis of a new design requires balancing of trade-offs that arise from multiple competing design objectives and constraints. Early-stage design synthesis typically does not consider detailed technical constraints; a task left to late-stage mathematical design optimisation to refine an already-determined configuration. The recently developed Multi-Objective Monotonicity Analysis (MOMA) has shown that design optimisation can be used successfully in configuration redesign. This article extends the MOMA approach to early-stage design. Synthesis of an aptly named ideal design is achieved by focusing on the avoidance or reduction of trade-offs and by managing active constraints across all stages of the design process. The ideal design meets a set of formal conditions, which provide the basis for a systematic collection of corresponding design principles that can be selectively combined to create new embodiments, avoiding overly restrictive trade-offs and constraints. These principles are consistent with the decision making of experienced mechanical designers, shown here in the industrial practice for designing drug delivery devices.

Information

Type
Research Article
Creative Commons
Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - SA
This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http://creativecommons.org/licenses/by-nc-sa/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is used to distribute the re-used or adapted article and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use.
Copyright
© The Author(s), 2025. Published by Cambridge University Press
Figure 0

Table 1. How monotonicity analysis can reveal the shared design variables and active constraints that cause trade-offs between design objectives

Figure 1

Figure 1. The embodiment design and initial dimensioning phase is characterised by inherently different activities (illustrated by the blue lines moving between design points) (1) identification of feasible design points, (2) optimisation of the initial configuration towards a Pareto-optimal design point and (3) changing the initial towards an improved configuration, a new Pareto-optimal design respectively (adapted from Sigurdarson et al. (2022b)).

Figure 2

Figure 2. The core functional elements of the FlexTouch injection device design.

Figure 3

Figure 3. The selection of a lead screw rather than, e.g., a rack and pinion allows low friction without elongating or widening the device. The introduction of the purple component in View 2, with the torque transferring key on the smallest possible diameter, and the positional control on the largest diameter (via the dosing ratchet), almost eliminates the trade-off between mechanical efficiency and dosing accuracy.

Figure 4

Figure 4. The key design variables in the dimensioning of two ubiquitous working principles for accurate conversion of rotation into linear motion: lead screw and rack and pinion mechanisms.

Figure 5

Table 2. Partial monotonicity table of a lead screw compared to that of a rack and pinion, of key design variables shown in Figure 4 w.r.t. device diameter ($ {D}_D $), mechanical efficiency ($ -\eta $), dosing inaccuracy $ {\unicode{x025B}}_d $ and device length $ {L}_D $

Figure 6

Figure 5. Beneficial layering: The location of the activation splines in the FlexTouch is beneficial for several reasons. The torque spring is mounted between the teal component and the red component.Relevant Design Objectives: Minimise device diameter, minimise activation force, maximise dose accuracy.Relevant Inequality Constraints: Interface stress in the activation spline, tangential assembly clearance in the spline interface, feature size (i.e., moulding injection pressure).Design Guidelines Involved: $ {\mathrm{G}}_{2.1}^{\chi } $ and $ {\mathrm{G}}_{2.2}^{\chi } $.

Figure 7

Figure 6. Beneficial Integration. By driving much functionality in the dosing engine using a single torque spring, and using working principles for sub-functions which rely on rotation, the FlexTouch avoids numerous contributors to the trade-offs between synchronisation and angular accuracy on one side and mechanical efficiency on the other.Relevant Design Objectives: Minimise device diameter, scale display error, maximise dosing speed and scale number size and resolution,Design Guidelines Involved: $ {\mathrm{G}}_{1.1}^{\dim \left(\mathbf{x}\right)} $, $ {\mathrm{G}}_{1.4}^{\dim \left(\mathbf{x}\right)} $, $ {\mathrm{G}}_{2.1}^{\chi } $,$ {\mathrm{G}}_{2.2}^{\chi } $.