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Three-dimensional neuronal cell culture: in pursuit of novel treatments for neurodegenerative disease

Published online by Cambridge University Press:  03 October 2017

Sarah-Sophia D. Carter ,
Xiao Liu ,
Zhilian Yue  and
Gordon G. Wallace
Sarah-Sophia D. Carter
Affiliation:
ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, AIIM Facility, University of Wollongong, NSW 2522, Australia Utrecht University, Utrecht, The Netherlands
Xiao Liu
Affiliation:
ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, AIIM Facility, University of Wollongong, NSW 2522, Australia
Zhilian Yue
Affiliation:
ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, AIIM Facility, University of Wollongong, NSW 2522, Australia
Gordon G. Wallace*
Affiliation:
ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, AIIM Facility, University of Wollongong, NSW 2522, Australia
*
Address all correspondence to Gordon G. Wallace at gwallace@uow.edu.au
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Abstract

To gain a better understanding of the underlying mechanisms of neurological disease, relevant tissue models are imperative. Over the years, this realization has fuelled the development of novel tools and platforms, which aim at capturing in vivo complexity. One example is the field of biofabrication, which focuses on fabrication of three-dimensional (3D) biologically functional products in a controlled and automated manner. Herein, we provide a general overview of classical 3D cell culture platforms, particularly in the context of neurodegenerative disease. Subsequently, the focus is put on bioprinting-based biofabrication, its potential to advance 3D neuronal cell culture and, to conclude, the relevant translational bottlenecks, which will need to be considered as the field evolves.

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Type
Biomaterials for 3D Cell Biology Prospective Articles
Information
MRS Communications , Volume 7 , Issue 3 , September 2017 , pp. 320 - 331
Copyright
Copyright © Materials Research Society 2017 

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