We read with interest the article of Faghfouri et al. ^{(Reference Faghfouri, Baradaran and Khabbazi1)} regarding the ‘Profiling Inflammatory Cytokines Following Zinc Supplementation: A Systematic Review and Meta-analysis of Randomized Controlled Trials’ and we would like to point out three concerns regarding the study selection presented in this article. First, although the authors searched electronic databases (PubMed, Scopus, Web of Science and Embase), three eligible studies were ignored^{(Reference Ahmad and Al-Ahmare2–Reference Rahfiludin, Wirjatmadi and Agusni4)}. Second, the authors mentioned that non-randomised design studies and also articles conducted on juvenile subjects (10–19 years)⁽⁵⁾ were excluded; however, two articles were included in the analysis^{(Reference Beserra de Moura, Mello Soares and de Lima Barros6,Reference Kara, Ozal and Gunay7)} . Third, another article was carried out on pregnant women^{(Reference Roshanravan, Tarighat-Esfanjani and Alamdari8)}, which should be excluded from analysis because the condition of inflammatory cytokines and also the effect of supplementation on pregnant women are relatively different from non-pregnant adults. In view of the deficiencies mentioned above, it is suggested that the analysis should be repeated.