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Accepted manuscript

Persistent structural alteration of the extended limbic system in adolescents with childhood maltreatment

Published online by Cambridge University Press:  20 January 2026

Julia Ruiz-Fernandez Open the ORCID record for Julia Ruiz-Fernandez [Opens in a new window] ,
Aveline Aouidad ,
Marie-Laure Paillère-Martinot Open the ORCID record for Marie-Laure Paillère-Martinot [Opens in a new window] ,
Alice V. Chavanne Open the ORCID record for Alice V. Chavanne [Opens in a new window] ,
Tobias Banaschewski Open the ORCID record for Tobias Banaschewski [Opens in a new window] ,
Gareth J Barker Open the ORCID record for Gareth J Barker [Opens in a new window] ,
Andreas Becker ,
Arun L.W. Bokde Open the ORCID record for Arun L.W. Bokde [Opens in a new window] ,
Rüdiger Brühl Open the ORCID record for Rüdiger Brühl [Opens in a new window]  and
Sylvane Desrivières
...Show all authors
Julia Ruiz-Fernandez
Affiliation:
Ecole Normale Supérieure Paris-Saclay, Université Paris-Saclay, INSERM U1299 “Developmental Trajectories & Psychiatry”; Mathematics department, Centre Borelli CNRS UMR9010, Gif-sur-Yvette, France
Aveline Aouidad
Affiliation:
Ecole Normale Supérieure Paris-Saclay, Université Paris-Saclay, INSERM U1299 “Developmental Trajectories & Psychiatry”; Mathematics department, Centre Borelli CNRS UMR9010, Gif-sur-Yvette, France
Marie-Laure Paillère-Martinot
Affiliation:
Ecole Normale Supérieure Paris-Saclay, Université Paris-Saclay, INSERM U1299 “Developmental Trajectories & Psychiatry”; Mathematics department, Centre Borelli CNRS UMR9010, Gif-sur-Yvette, France AP-HP Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris
Alice V. Chavanne
Affiliation:
Ecole Normale Supérieure Paris-Saclay, Université Paris-Saclay, INSERM U1299 “Developmental Trajectories & Psychiatry”; Mathematics department, Centre Borelli CNRS UMR9010, Gif-sur-Yvette, France
Tobias Banaschewski
Affiliation:
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany
Gareth J Barker
Affiliation:
Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom
Andreas Becker
Affiliation:
Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center, von-Siebold-Str. 5, 37075, Göttingen, Germany
Arun L.W. Bokde
Affiliation:
Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
Rüdiger Brühl
Affiliation:
Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany
Sylvane Desrivières
Affiliation:
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK
Herta Flor
Affiliation:
Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany Department of Psychology, School of Social Sciences, University of Mannheim, 68131, Mannheim, Germany
Antoine Grigis
Affiliation:
NeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France
Yvonne Grimmer
Affiliation:
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany
Hugh Garavan
Affiliation:
Departments of Psychiatry and Psychology, University of Vermont, 05405 Burlington, Vermont, USA
Penny Gowland
Affiliation:
Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Andreas Heinz
Affiliation:
Department of Psychiatry and Psychotherapy CCM, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Corinna Insensee
Affiliation:
Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center, von-Siebold-Str. 5, 37075, Göttingen, Germany
Frauke Nees
Affiliation:
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, China.
Dimitri Papadopoulos Orfanos
Affiliation:
NeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France
Tomáš Paus
Affiliation:
Department of Psychiatry, Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada Departments of Psychiatry and Psychology, University of Toronto, Toronto, Ontario, Canada
Jani Penttilä
Affiliation:
Department of Social and Health Care, Psychosocial Services Adolescent Outpatient Clinic Kauppakatu 14, Lahti, Finland
Luise Poutska
Affiliation:
Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany
Nathalie Holz
Affiliation:
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany
Christian Beauchl
Affiliation:
Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany
Michael N Smolka
Affiliation:
Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany
Argyris Stringaris
Affiliation:
University College London, London, United Kingdom
Nilakshi Vaidya
Affiliation:
Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Germany
Betteke van Noort
Affiliation:
MSB Medical School Berlin, Hochschule für Gesundheit und Medizin, Siemens Villa, Berlin
Henrik Walter
Affiliation:
Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany
Robert Whelan
Affiliation:
School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland
Gunter Schumann
Affiliation:
Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Germany Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, China.
David Cohen
Affiliation:
Ecole Normale Supérieure Paris-Saclay, Université Paris-Saclay, INSERM U1299 “Developmental Trajectories & Psychiatry”; Mathematics department, Centre Borelli CNRS UMR9010, Gif-sur-Yvette, France AP-HP Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris Institut des Systèmes Intelligents et de Robotique, Sorbonne Université, ISIR CNRS UMR 7222, Paris, France
Jean-Luc Martinot*
Affiliation:
Ecole Normale Supérieure Paris-Saclay, Université Paris-Saclay, INSERM U1299 “Developmental Trajectories & Psychiatry”; Mathematics department, Centre Borelli CNRS UMR9010, Gif-sur-Yvette, France Department of Psychiatry, LabD-Psy, EPS Barthélémy Durand, Etampes, France.
Eric Artiges*
Affiliation:
Ecole Normale Supérieure Paris-Saclay, Université Paris-Saclay, INSERM U1299 “Developmental Trajectories & Psychiatry”; Mathematics department, Centre Borelli CNRS UMR9010, Gif-sur-Yvette, France Department of Psychiatry, LabD-Psy, EPS Barthélémy Durand, Etampes, France.
*
*Correspondence: jean-luc.martinot@inserm.fr; eric.artiges@inserm.fr
*Correspondence: jean-luc.martinot@inserm.fr; eric.artiges@inserm.fr

Abstract

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Keywords

Child abuseAdversityAdolescenceMagnetic resonance imagingLongitudinal studies

Information

Type
Research Article
Information
European Psychiatry , Accepted manuscript , pp. 1 - 30
Creative Commons
Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - ND
This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
Copyright
© The Author(s), 2026. Published by Cambridge University Press on behalf of European Psychiatric Association

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contributed equally to this work.

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