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Task-State Functional MRI of Brain Regions with Reduced Activation in Aphasia Patients: A Meta-analysis
Published online by Cambridge University Press: 03 October 2024
Abstract
Objective:
Language is one of the most celebrated hallmarks of human cognition. With the continuous improvement of medical technology, functional MRI (fMRI) has been used in aphasia. Although many related studies have been carried out, most studies have not extensively focused on brain regions with reduced activation in aphasic patients. The aim of this study was to identify brain regions normally activated in healthy controls but with reduced activation in aphasic patients during fMRI language tasks.
Methods:
We collected all previous task-state fMRI studies of secondary aphasia. The brain regions showed normal activation in healthy controls and reduced activation in aphasic patients were conducted activation likelihood estimation (ALE) meta-analysis to obtain the brain regions with consistently reduced activation in aphasic patients.
Results:
The ALE meta-analysis revealed that the left inferior frontal gyrus, left middle temporal gyrus, left superior temporal gyrus, left fusiform gyrus, left lentiform nucleus and the culmen of the cerebellum were the brain regions with reduced activation in aphasic patients.
Discussion:
These findings from the ALE meta-analysis have significant implications for understanding the language network and the potential for recovery of language functions in individuals with aphasia.
Résumé
IRMf en cours de tâche des régions cérébrales à activation réduite chez des patients aphasiques: une méta-analyse
Le langage est l’une des caractéristiques les plus renommées de la cognition humaine. Avec l’amélioration continue de la technologie médicale, l’IRM fonctionnelle (IRMf) est désormais utilisée dans le cas de l’aphasie. Bien que de nombreuses études connexes aient été réalisées, la plupart d’entre elles n’ont pas porté sur les régions du cerveau de patients aphasiques dont l’activation est réduite. L’objectif de cette étude était donc d’identifier, lors de tâches linguistiques analysées par IRMf, les régions cérébrales normalement activées chez des témoins sains et celles dont l’activation était réduite chez des patients aphasiques.
Nous avons rassemblé toutes les études antérieures d’IRMf de l’aphasie secondaire. Les régions cérébrales présentant une activation normale chez des témoins sains et une activation réduite chez des patients aphasiques ont fait l’objet d’une méta-analyse de l’estimation de la vraisemblance de l’activation (EVA) afin de déterminer les régions cérébrales présentant une activation réduite constante chez des patients aphasiques.
La méta-analyse de l’EVA a révélé que le gyrus frontal inférieur gauche, le gyrus temporal moyen gauche, le gyrus temporal supérieur gauche, le gyrus fusiforme gauche, le noyau lenticulaire gauche et le culmen du cervelet étaient les régions cérébrales présentant une activation réduite chez les patients aphasiques.
En somme, ces résultats de la méta-analyse de l’EVA ont des implications significatives pour la compréhension du réseau du langage et la récupération potentielle des fonctions langagières chez les patients aphasiques.
Keywords
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- © The Author(s), 2024. Published by Cambridge University Press on behalf of Canadian Neurological Sciences Federation
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