Hostname: page-component-89b8bd64d-shngb Total loading time: 0 Render date: 2026-05-11T08:11:57.644Z Has data issue: false hasContentIssue false
  • English
  • Français

Frequency of soy food consumption and serum isoflavone concentrations among Chinese women in Shanghai

Published online by Cambridge University Press:  02 January 2007

Cara L Frankenfeld ,
Johanna W Lampe ,
Jackilen Shannon ,
Dao L Gao ,
Roberta M Ray ,
Joann Prunty ,
Thomas F Kalhorn ,
Kristiina Wähälä ,
Ruth E Patterson  and
David B Thomas
Cara L Frankenfeld
Affiliation:
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North M4-B402, Seattle, WA 98109, USA Department of Epidemiology, University of Washington, Seattle, WA, USA
Johanna W Lampe*
Affiliation:
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North M4-B402, Seattle, WA 98109, USA Department of Epidemiology, University of Washington, Seattle, WA, USA
Jackilen Shannon
Affiliation:
Portland Veterans Administration Medical Center, Portland, OR, USA
Dao L Gao
Affiliation:
Department of Epidemiology, Zhong Shan Hospital Cancer Center, Shanghai, People's Republic of, China
Roberta M Ray
Affiliation:
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North M4-B402, Seattle, WA 98109, USA
Joann Prunty
Affiliation:
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North M4-B402, Seattle, WA 98109, USA
Thomas F Kalhorn
Affiliation:
Mass Spectrometry Center, University of Washington, Seattle, WA, USA
Kristiina Wähälä
Affiliation:
Department of Chemistry, University of Helsinki, Helsinki, Finland
Ruth E Patterson
Affiliation:
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North M4-B402, Seattle, WA 98109, USA Department of Epidemiology, University of Washington, Seattle, WA, USA
David B Thomas
Affiliation:
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North M4-B402, Seattle, WA 98109, USA Department of Epidemiology, University of Washington, Seattle, WA, USA
*
*Corresponding author: Email jlampe@fhcrc.org
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the 'Save PDF' action button.
Objective:

The food-frequency questionnaire (FFQ) can be an efficient tool to evaluate dietary intake in large, population-based studies, especially for specific foods. The objective of this study was to validate the assessment of soy and isoflavone (daidzein and genistein) intakes, measured by an FFQ, by comparing intakes with serum isoflavone concentrations.

Design and setting:

Soy and isoflavone intakes and serum isoflavone concentrations were determined as part of a case–control study of dietary factors and risks of benign breast disease and breast cancer. The FFQ, administered during an in-person interview, included six soy-specific line items. Blood was drawn within one week of FFQ completion.

Subjects:

In total, 1823 women living in Shanghai, People's Republic of China.

Results:

In this population, soybean milk, fresh bean curd and other bean foods were eaten once per week, and fermented bean curd, fried bean curd puff and soybeans were eaten less than once per week. A significant linear trend (P > 0.01) in serum isoflavone concentrations across increasing categories of soy and isoflavone intakes was observed, indicating that soy and isoflavone intakes, measured by the FFQ, well distinguished serum isoflavone concentrations. Linear trends were also observed in both case and control groups in stratified analyses, suggesting little differential bias by case–control status.

Conclusions:

The results suggest that the FFQ provides a useful marker of soy food consumption and isoflavone exposure in this population.

Keywords

SoyFood-frequency questionnaireIsoflavoneSerum

Information

Type
Research Article
Information
Public Health Nutrition , Volume 7 , Issue 6 , September 2004 , pp. 765 - 772
Copyright
Copyright © CAB International 2004

References

1Adlercreutz, H, Mazur, W. Phyto-oestrogens and Western diseases. Annals of Medicine 1997; 29: 95–120.CrossRefGoogle ScholarPubMed
2Hopert, A-C, Beyer, A, Frank, K, Strunck, E, Wunsche, W, Vollmer, G. Characterization of estrogenicity of phytoestrogens in an endometrial-derived experimental model. Environmental Health Perspectives 1998; 106: 581–6.CrossRefGoogle Scholar
3Breinholt, V, Hossaini, A, Svendsen, GW, Brouwer, C, Nielson, SE. Estrogenic activity of flavonoids in mice. The importance of estrogen receptor distribution, metabolism and bioavailability. Food and Chemical Toxicology 2000; 38: 555–64.CrossRefGoogle ScholarPubMed
4Setchell, KDR. Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. American Journal of Clinical Nutrition 1998; 68(Suppl.): 1333S–46S.Google ScholarPubMed
5Guthrie, JR, Ball, M, Murkies, A, Dennerstein, L. Dietary phytoestrogen intake in mid-life Australian-born women: relationship to health variables. Climacteric 2000; 3: 254–61.CrossRefGoogle ScholarPubMed
6Keinan-Boker, L, Peeters, PHM, Mulligan, AA, Navarro, C, Slimani, N, Mattison, I, et al. Soy product consumption in 10 European countries: the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutrition 2002; 5: 1217–26.CrossRefGoogle ScholarPubMed
7Dai, Q, Shu, XO, Jin, F, Potter, JD, Kushi, LH, Teas, J, et al. Population-based case-control study of soyfood intake and breast cancer risk in Shanghai. British Journal of Cancer 2001; 85: 372–8.CrossRefGoogle ScholarPubMed
8Chen, Z, Zheng, W, Custer, LJ, Dai, Q, Shu, XO, Jin, F, et al. Usual dietary consumption of soy foods and its correlation with the excretion rate of isoflavonoids in overnight urine samples among Chinese women in Shanghai. Nutrition and Cancer 1999; 33: 82–7.CrossRefGoogle ScholarPubMed
9Ho, SC, Woo, JL, Leung, SS, Sham, AL, Lam, TH, Janus, ED. Intake of soy products is associated with better plasma lipid profiles in the Hong Kong Chinese population. Journal of Nutrition 2000; 130: 2590–3.CrossRefGoogle ScholarPubMed
10Willett, W. Nutritional Epidemiology. New York: Oxford University Press, 1990.Google Scholar
11Thomas, DB, Gao, DL, Ray, RM, Wang, WW, Allison, CJ, Chen, FJ, et al. Randomized trial of breast self-examination in Shanghai: final results. Journal of the National Cancer Institute 2002; 94: 1445–57.CrossRefGoogle ScholarPubMed
12 Carolina Population Center, University of North Carolina at Chapel Hill. The China Health and Nutrition Survey [online], 1999. Available at http://www.cpc.unc.edu/projects/china/china_home.htmlGoogle Scholar
13US Department of Agriculture – Iowa State University Database on the Isoflavone Content of Foods, Release 1.3 – 2002 [online], 2002. Available at http://www.nal.usda.gov/fnic/foodcomp/Data/isoflav/isoflav.htmlGoogle Scholar
14Franke, AA, Hankin, JH, Yu, MC, Maskarinec, G, Low, SH, Custer, LJ. Isoflavone levels in soy foods consumed by multiethnic populations in Singapore and Hawaii. Journal of Agricutural and Food Chemistry 1999; 47: 977–86.CrossRefGoogle ScholarPubMed
15Gamache, PH, Acworth, IN. Analysis of phytoestrogens and polyphenols in plasma, tissue, and urine using HPLC with coulometric array detection. Proceedings of the Society for Experimental Biology and Medicine 1998; 217: 274–80.CrossRefGoogle ScholarPubMed
16Lundh, T, Pettersson, H, Kiessling, K. Liquid chromatographic determination of the estrogens, daidzein, formononetin, coumestrol, and equol in bovine plasma and urine. Journal of the Association of Official Analytical Chemists 1988; 71: 938–41.Google ScholarPubMed
17Coward, L, Kirk, M, Albin, N, Barnes, S. Analysis of plasma isoflavones by reversed-phase HPLC–multiple reaction ion monitoring-mass spectrometry. Clinica Chimica Acta 1996; 247: 121–42.CrossRefGoogle ScholarPubMed
18Yearly climate info – Shanghai Municipality. Travel China Guide [online], 2003. Available at http://www.travelchinaguide.com/climate/shanghai.htmGoogle Scholar
19Yamamoto, S, Sobue, T, Sasaki, S, Kobayahi, M, Arai, Y, Uehara, M, et al. Validity and reproducibility of a self-administered food-frequency questionnaire to assess isoflavone intake in a Japanese population in comparison with dietary records and blood and urine isoflavones. Journal of Nutrition 2001; 131: 2741–7.CrossRefGoogle Scholar
20Arai, Y, Uehara, M, Sato, Y, Kimira, M, Eboshida, A, Adlercreutz, H, et al. Comparison of isoflavones among dietary intake, plasma concentration and urinary excretion for accurate estimation of phytoestrogen intake. Journal of Epidemiology 2000; 10: 127–35.CrossRefGoogle ScholarPubMed
21Maskarinec, G, Singh, S, Meng, L, Franke, AA. Dietary soy intake and urinary isoflavone excretion among women from a multiethnic population. Cancer Epidemiology, Biomarkers & Prevention 1998; 7: 613–9.Google ScholarPubMed
22Huang, MH, Harrison, GG, Mohamed, MM, Gornbein, JA, Henning, SM, Go, VL, et al. Assessing the accuracy of a food frequency questionnaire for estimating usual intake of phytoestrogen. Nutrition and Cancer 2000; 37: 145–54.CrossRefGoogle Scholar
23Willett, WC. Nutritional Epidemiology, 2nd ed. New York: Oxford University Press, 1998.CrossRefGoogle Scholar
24Nagata, C, Shimizu, H, Takami, R, Hayashi, M, Takeda, N, Yasuda, K. Soy product intake and serum isoflavonoid and estradiol concentrations in relation to bone mineral density in postmenopausal Japanese women. Osteoporosis International 2002; 13: 200–4.CrossRefGoogle ScholarPubMed
25Morton, MS, Arisaka, O, Miyake, N, Morgan, LD, Evans, BA. Phytoestrogen concentrations in serum from Japanese men and women over forty years of age. Journal of Nutrition 2002; 132: 3168–71.CrossRefGoogle ScholarPubMed
26Frankenfeld, CL, Patterson, RE, Kalhorn, TF, Skor, HE, Howald, WN, Lampe, JW. Validation of a soy food frequency questionnaire with plasma concentrations of isoflavones in US adults. Journal of the American Dietetic Association 2002; 102: 1407–13.CrossRefGoogle ScholarPubMed
27Frankenfeld, CL, Patterson, RE, Horner, NK, Neuhouser, ML, Skor, HE, Kalhorn, TF, et al. Validation of a soy food-frequency questionnaire and evaluation of correlates of plasma isoflavone concentrations in postmenopausal women. American Journal of Clinical Nutrition 2003; 77: 674–80.CrossRefGoogle ScholarPubMed
28De Kleijn, MJ, van der Schouw, YT, Wilson, PW, Adlercreutz, H, Mazur, W, Grobbee, DE, et al. Intake of dietary phytoestrogens is low in postmenopausal women in the United States: The Framingham Study. Journal of Nutrition 2001; 131: 1826–32.CrossRefGoogle ScholarPubMed
29Jakes, RW, Duffy, SW, Ng, FC, Gao, F, Ng, EH. Mammographic parenchymal patterns and self-reported soy intake in Singapore Chinese women. Cancer Epidemiology, Biomarkers & Prevention 2002; 11: 608–13.Google ScholarPubMed
30Sun, CL, Yuan, JM, Arakawa, K, Low, SH, Lee, HP, Yu, MC. Dietary soy and increased risk of bladder cancer: the Singapore Chinese Health Study. Cancer Epidemiology, Biomarkers & Prevention 2002; 11: 1674–7.Google ScholarPubMed
31Setchell, KDR, Faughnan, MS, Avades, T, Zimmer-Nechemias, L, Brown, NM, Wolfe, BE, et al. Comparing the pharmokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women. American Journal of Clinical Nutrition 2003; 77: 411–9.CrossRefGoogle Scholar
32Watanabe, S, Yamaguchi, M, Sobue, T, Takahashi, T, Miura, T, Arai, Y, et al. Pharmacokinetics of soybean isoflavones in plasma, urine and feces of men after ingestion of 60 g baked soybean powder (kinako). Journal of Nutrition 1998; 128: 1710–5.CrossRefGoogle ScholarPubMed
33King, RA, Bursill, DB. Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans. American Journal of Clinical Nutrition 1998; 67: 867–72.CrossRefGoogle ScholarPubMed
34Lampe, JW. Isoflavonoid and lignan phytoestrogens as dietary biomarkers. Journal of Nutrition 2003; 133(Suppl. 3): 956S–64S.CrossRefGoogle ScholarPubMed