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Polyurethane-based bioadhesive synthesized from polyols derived from castor oil (Ricinus communis) and low concentration of chitosan

Published online by Cambridge University Press:  25 September 2017

Yomaira L. Uscátegui ,
Said J. Arévalo-Alquichire ,
José A. Gómez-Tejedor ,
Ana Vallés-Lluch ,
Luis E. Díaz  and
Manuel F. Valero
Yomaira L. Uscátegui
Affiliation:
Doctoral Program in Biosciences, Research Group on Energy, Materials and Environment, Universidad de La Sabana, Chia 140013, Colombia
Said J. Arévalo-Alquichire
Affiliation:
Doctoral Program in Biosciences, Research Group on Energy, Materials and Environment, Universidad de La Sabana, Chia 140013, Colombia
José A. Gómez-Tejedor
Affiliation:
Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Valencia 46022, Spain; and Biomedical Research Networking Center in Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Valencia 46022, Spain
Ana Vallés-Lluch
Affiliation:
Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Valencia 46022, Spain
Luis E. Díaz
Affiliation:
Bioprospecting Research Group, Universidad de La Sabana, Chía, Cundinamarca 140013, Colombia
Manuel F. Valero*
Affiliation:
Research Group on Energy, Materials and Environment, Universidad de La Sabana, Chia 140013, Colombia
*
a)Address all correspondence to this author. e-mail: manuel.valero@unisabana.edu.co
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Abstract

Polyurethane-based bioadhesive was synthesized with polyols derived from castor oil (chemically modified and unmodified) and hexamethylene diisocyanate with chitosan addition as a bioactive filler. The objective was to evaluate the effect of type of polyols with the incorporation of low-concentrations of chitosan on the mechanical and biological properties of the polymer to obtain suitable materials in the design of biomaterials. The results showed that increasing physical crosslinking increased the mechanical and adhesive properties. An in vitro cytotoxic test of polyurethanes showed cellular viability. The biocompatibility of the polyurethanes favors the adhesion of L929 cells at 6, 24, and 48 h. The polyurethanes showed bacterial inhibition depending on the polyol and percentage of chitosan. The antibacterial effect of the polyurethanes for Escherichia coli decreased 60–90% after 24 h. The mechanical and adhesive properties together with biological response in this research suggested these polyurethanes as external application tissue bioadhesives.

Keywords

adhesionbiomedical deviceschemical reaction
Type
Articles
Information
Journal of Materials Research , Volume 32 , Issue 19 , 16 October 2017 , pp. 3699 - 3711
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Copyright
Copyright © Materials Research Society 2017 

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Footnotes

Contributing Editor: Lakshmi Nair

References

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