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Excessive vitamin D content of a standard iron-deficient diet for rats

Published online by Cambridge University Press:  25 March 2008

Stella M. Triggs  and
R. Bailey
Stella M. Triggs
Affiliation:
Departments of Pathology and Haematology, Welsh National School of Medicine, Health Park, Cardiff CF4 4XN
R. Bailey
Affiliation:
Departments of Pathology and Haematology, Welsh National School of Medicine, Health Park, Cardiff CF4 4XN
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Abstract

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1. The observation that thyroid C cell hyperplasia occurred in rats given the iron-deficient diet described by McCall, Newman, O'Brien, Valberg & Witts (1962) prompted a closer study of the preparation and constituents of this diet..

2. It became apparent that there was a discrepancy between the amounts of fat-soluble vitamins in the dietary formulation reported and the supposed final content of the diet. A diet prepared as described by McCall et al. (1962) contains 1000 μg (40000 i.u.) ergocalciferol and 10 μg (14 500 i.u.) retinyl palmitate/kg..

3. An experiment was designed to study the effect of Fe-deficient and Fe-supplemented, high-vitamin-D diets, and an Fe-supplemented, normal-vitamin-D diet, on thyroid C cell volume and serum calcium concentration..

4. Thyroid C cell volumes and serum Ca concentrations were significantly higher in both groups given excess vitamin D than in the group given the Fe-supplemented, normal-vitamin-D diet. It is evident therefore, that hypervitaminosis D was the cause of the morphological and biochemical changes found in rats given the McCall et al. (1962) diet.

Information

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 35 , Issue 2 , March 1976 , pp. 277 - 280
Copyright
Copyright © The Nutrition Society 1976

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