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How and where does nitric oxide affect cerebellar synaptic plasticity? New methods for investigating its action

Published online by Cambridge University Press:  19 May 2011

Lynn J. Bindman
Affiliation:
Department of Physiology, University College London, Gower St., London, WC1E 6BT, United Kingdom. lkiedr@psych.ulc.edu

Abstract

The role of nitric oxide in cerebellar synaptic plasticity is controversial. Two recent papers on nitric oxide-(NO) and synaptic plasticity are discussed which use new methods for investigating the actions of NO and suggest that under certain conditions it is an essential anterograde messenger. In the light of current thinking about the diversity of expression of hippocampal LTP, should a presynaptic contribution to cerebellar LTD be re-examined? If NO acts orthogradely, might its product cGMP have a retrograde action? [CRÉPEL et al.; LINDEN; VINCENT]

Information

Type
Open Peer Commentary
Copyright
Copyright © Cambridge University Press 1996

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