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Growth Hormone Secretion: Its Regulation and the Influence of Nutritional Factors

Published online by Cambridge University Press:  14 December 2007

Richard J. M. Ross  and
Charles R. Buchanan
Richard J. M. Ross
Affiliation:
Dept of Medicine, King's College School of Medicine, Bessemer Rd, London SE5
Charles R. Buchanan
Affiliation:
Dept of Growth and Development, Institute of Child Health, 30 Guilford St, London WCIN IEH
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Abstract

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Type
Research Article
Information
Nutrition Research Reviews , Volume 3 , Issue 1 , January 1990 , pp. 143 - 162
Copyright
Copyright © The Nutrition Society 1990

References

REFERENCES

Abrams, R. L., Grumbach, M. M. & Kaplan, S. L. (1971). The effect of administration of human growth hormone on plasma growth hormone, cortisol, glucose, and free fatty acid response to insulin: evidence for growth hormone autoregulation in man. Journal of Clinical Investigation 50, 940–950.Google Scholar
Adlard, P., Buzi, F., Jones, J., Stanhope, R. & Preece, M. A. (1987). Physiological growth hormone secretion during slow-wave sleep in short prepubertal children. Clinical Endocrinology 27, 355–361.CrossRefGoogle ScholarPubMed
Ahmad, I., Steggles, A. W., Carrillo, A. J. & Finkelstein, J. A. (1989). Obesity-related and sex-related alterations in growth hormone messenger RNA levels. Molecular and Cellular Endocrinology 65, 103–109.CrossRefGoogle Scholar
Alba-Roth, J., Müller, O. A., Schopohl, J. & von Werder, K. (1988). Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. Journal of Clinical Endocrinology and Metabolism 67, 1186–1189.CrossRefGoogle ScholarPubMed
Argente, J., Brion, Evain D., Donnadieu, M., Garnier, P., Vaudry, H. & Job, J. C. (1987). Impaired response of growth hormone-releasing hormone (GHRH) measured in plasma after L-dopa stimulation in patients with idiopathic delayed puberty. Acta Paediatrica Scandinavica 76, 266–270.Google Scholar
Arimura, A., Smith, W. D. & Schally, A. V. (1976). Blockade of the stress-induced decrease in blood GH by anti-somatostatin serum in rats. Endocrinology 98, 540–543.CrossRefGoogle ScholarPubMed
Asplin, C. M., Faria, A. C. S., Carlsen, E. C., Vaccaro, V. A., Carr, R. E., Iranmaesh, A., Lee, M. M., Veldhuis, J. D. & Evans, W. S. (1989). Alterations in the pulsatile mode of growth hormone release in men and women with insulin-dependent diabetes mellitus. Journal of Clinical Endocrinology and Metabolism 69, 239–245.CrossRefGoogle ScholarPubMed
Atinmo, T., Baldijao, C., Houpt, K. A., Pond, W. G. & Barnes, R. H. (1978). Plasma levels of growth hormone and insulin in protein malnourished vs normal growing pigs in response to arginine or glucose infusion. Journal of Animal Science 46, 409–416.CrossRefGoogle ScholarPubMed
Balzano, S., Loche, S., Murtas, M. L., Fanni, T., Sica, V., Pintor, C. & Martino, E. (1989). Potentiation of cholinergic tone counteracts the suppressive effect of oral glucose administration on the GH response to GHRH in man. Hormone and Metabolic Research 21, 52–53.CrossRefGoogle ScholarPubMed
Bansal, S. A., Lee, L. A. & Woolf, P. D. (1981). Dopaminergic stimulation and inhibition of growth hormone secretion in normal man: studies of the pharmacologic specificity. Journal of Clinical Endocrinology and Metabolism 53, 1273–1277.Google Scholar
Barinaga, M., Bilezikjian, L. M., Vale, W. W., Rosenfeld, M. G. & Evans, R. M. (1985). Independent effects of growth hormone releasing factor on growth hormone release and gene transcription. Nature 314, 279–281.CrossRefGoogle ScholarPubMed
Baxter, R. C. & Cowell, C. T. (1987). Diurnal rhythm of growth hormone-independent binding protein for insulin-like growth factors in human plasma. Journal of Clinical Endocrinology and Metabolism 65, 432–440.Google Scholar
Becker, D. J. (1983). The endocrine responses to protein calorie malnutrition. Annual Review of Nutrition 3, 187–212.Google Scholar
Bercu, B. B. & Diamond, F. B. (1986). Growth hormone neurosecretory dysfunction. In Clinics in Endocrinology and Metabolism, vol. 15, pp. 537–590 [Savage, M. O. and Randall, R. A., editors]. London: W. B. Saunders.Google Scholar
Berelowitz, M., Szabo, M., Frohman, L. A., Firestone, S. & Chu, L. (1981). Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. Science 212, 1279–1281.CrossRefGoogle ScholarPubMed
Bloch, B., Brazeau, P., Ling, N., Böhlen, P., Esch, F., Wehrenberg, W. B., Benoit, R., Bloom, F. & Guillemin, R. (1983). Immunohistochemical detection of growth hormone-releasing factor in brain. Nature 301, 607–608.Google Scholar
Bohannon, N. J., Corp, E. S., Wilcox, B. J., Figlewicz, D. P., Dorsa, D. M. & Baskin, D. G. (1988). Characterization of insulin-like growth factor 1 receptors in the median eminence of the brain and their modulation by food restriction. Endocrinology 122, 1940–1947.CrossRefGoogle ScholarPubMed
Born, J., Muth, S. & Fehm, H. L. (1988). The significance of sleep onset and slow wave sleep for nocturnal release of growth hormone (GH) and cortisol. Psychoneuroendocrinology 13, 233–243.Google Scholar
Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M., Rivier, J. & Guillemin, R. (1973). Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 179, 77–79.CrossRefGoogle ScholarPubMed
Breier, B. H., Gluckman, P. D. & Bass, J. J. (1988). Influence of nutritional status and oestradiol-17β on plasma growth hormone, insulin-like growth factors-1 and -2 and the response to exogenous growth hormone in young steers. Journal of Endocrinology 118, 243–250.CrossRefGoogle Scholar
Buchanan, C. R., Stanhope, R., Adlard, P., Jones, J., Grant, D. B. & Preece, M. A. (1988). Gonadotrophin, growth hormone and prolactin secretion in children with primary hypothyroidism. Clinical Endocrinology 29, 427–436.Google Scholar
Burguera, B., Muruais, C., Peñalva, A., Dieguez, C. & Casanueva, F. F. (1990). Dual and selective actions of glucocorticoids upon basal and stimulated growth hormone release in man. Neuroendocrinology 51, 51–58.CrossRefGoogle ScholarPubMed
Casanueva, F. F., Villanueva, L., Cabranes, J. A., Cabezas-Cerrato, J. & Fernandez-Cruz, A. (1984). Cholinergic mediation of growth hormone secretion elicited by arginine, clonidine, and physical exercise in man. Journal of Clinical Endocrinology and Metabolism 59, 526–530.CrossRefGoogle ScholarPubMed
Casanueva, F. F., Villanueva, L., Dieguez, C., Diaz, Y., Cabranes, J. A., Szoke, B., Scanlon, M. F., Schally, A. V. & Fernandez-Cruz, A. (1987). Free fatty acids block growth hormone (GH) releasing hormone-stimulated GH secretion in man directly at the pituitary. Journal of Clinical Endocrinology and Metabolism 65, 634–642.Google Scholar
Cella, S. G., Moiraghi, V., Minuto, F., Barreca, A., Cocchi, D., Colonna, De Gennaro V., Reina, G. & Muller, E. E. (1989). Prolonged fasting or clonidine can restore the defective growth hormone secretion in old dogs. Acta Endocrinologica 121, 177–184.Google Scholar
Chihara, K., Kodama, H., Kaji, H., Kita, T., Kashio, Y., Okimura, Y., Abe, H. & Fujita, T. (1985). Augmentation by propranolol of growth hormone-releasing hormone-(1 44)-NH2-induced growth hormone release in normal short and normal children. Journal of Clinical Endocrinology and Metabolism 61, 229–233.CrossRefGoogle Scholar
Clemmons, D. R., Snyder, D. K., Williams, R. & Underwood, L. E. (1987). Growth hormone administration conserves lean body mass during dietary restriction in obese subjects. Journal of Clinical Endocrinology and Metabolism 64, 878–883.Google Scholar
Clemmons, D. R., Underwood, L. E., Dickerson, R. N., Brown, R. O., Hak, L. J., MacPhee, R. D. & Heizer, W. D. (1985). Use of plasma somatomedin-C/insulin-like growth factor 1 measurements to monitor the response to nutritional repletion in malnourished patients. American Journal of Clinical Nutrition 41, 191–198.CrossRefGoogle ScholarPubMed
Conway, S., Moherek, R., Mauceri, H. & Richardson, L. (1989). Sexually dimorphic characteristics of clonidine-induced growth hormone release and autofeedback. Journal of Clinical Endocrinology and Metabolism 125, 2475–2485.Google Scholar
Csizmadi, I., Brazeau, P. & Serri, O. (1989). Effect of dietary restriction and repeated growth hormone-releasing factor injections on growth hormone response to growth hormone-releasing factor in obese subjects. Metabolism 38, 1016–1021.Google Scholar
Daughaday, W. H., Hall, K., Salmon, W. D., Van den Brande, J. L. & Van Wyk, J. J. (1987). On the nomenclature of the somatomedins and insulin-like growth factors. Journal of Clinical Endocrinology and Metabolism 65, 1075–1076.Google Scholar
Davidson, M. B. (1987). Effect of growth hormone on carbohydrate and lipid metabolism. Endocrine Reviews 8, 115–131.Google Scholar
Davies, R. R., Turner, S. J., Cook, D., Alberti, K. G. M. M. & Johnston, D. G. (1985 a). The response of obese subjects to continuous infusion of human pancreatic growth hormone-releasing factor 1–44. Clinical Endocrinology 23, 521–525.Google Scholar
Davies, R. R., Turner, S. & Johnston, D. G. (1984). Oral glucose inhibits growth hormone secretion induced by human pancreatic growth hormone releasing factor 1–44 in normal man. Clinical Endocrinology 21, 477–481.CrossRefGoogle ScholarPubMed
Davies, R. R., Turner, S. J., Ørskov, H. & Johnston, D. G. (1985 b). The interaction of human pancreatic growth hormone releasing factor 1 44 with somatostatin in vivo in normal man. Clinical Endocrinology 23, 271–276.CrossRefGoogle ScholarPubMed
Davis, S. L. (1972). Plasma levels of prolactin, growth hormone and insulin in sheep following the infusion of arginine, leucine and phenylalanine. Endocrinology 91, 549–555.CrossRefGoogle ScholarPubMed
De Feo, P., Perriello, G., Torlone, E., Ventura, M. M., Santeusanio, F., Brunetti, P., Gerich, J. E. & Bolli, G. B. (1989). Demonstration of a role for growth hormone in glucose counter regulation. American Journal of Physiology 256, E835–E843.Google Scholar
Delitala, G., Palermo, M., Ross, R., Coy, D., Besser, G. M. & Grossman, A. (1987). Dopaminergic and cholinergic influences on the growth hormone response to growth hormone-releasing hormone in man. Neuroendocrinology 45, 243–247.Google Scholar
De Marinis, L., Folli, G., D'Amico, C., Mancini, A., Sambo, P., Tofani, A., Oradei, A. & Barbino, A. (1988). Differential effects of feeding on the ultradian variation of the growth hormone (GH) response to GH-releasing hormone in normal subjects and patients with obesity and anorexia nervosa. Journal of Clinical Endocrinology and Metabolism 66, 598–604.Google Scholar
Driver, P. M. & Forbes, J. M. (1981). Episodic growth hormone secretion in sheep in relation to time of feeding spontaneous meals and short term fasting. Journal of Physiology 317, 413–424.Google Scholar
El-Khodary, A. Z., Ball, M. F., Stein, B. & Canary, J. J. (1971). Effect of weight loss on the growth hormone response to arginine infusion in obesity. Journal of Clinical Endocrinology and Metabolism 32, 42–51.CrossRefGoogle ScholarPubMed
Finkelstein, J. W., Roffwarg, H. P., Boyar, R. M., Kream, J. & Hellman, L. (1972). Age-related change in the twenty-four-hour spontaneous secretion of growth hormone. Journal of Clinical Endocrinology and Metabolism 35, 665–671.Google Scholar
Foster, D. L., Ebling, F. J. P., Micka, A. F., Vannerson, L. A., Bucholz, D. C., Wood, R. I., Suttie, J. M. & Fenner, D. E. (1989). Metabolic interfaces between growth and reproduction. 1. Nutritional modulation of gonadotrophin, prolactin, and growth hormone secretion in the growth-limited female lamb. Endocrinology 125, 342–350.Google Scholar
Frantz, A. G. & Rabkin, M. T. (1965). Effects of estrogen and sex difference on secretion of human growth hormone. Journal of Clinical Endocrinology and Metabolism 25, 1470–1480.Google Scholar
Frasier, S. D. (1974). A review of growth hormone stimulation tests in children. Pediatrics 53, 929–937.CrossRefGoogle Scholar
Freeman, E., Buchanan, C. R., Jones, J., Preece, M. A. & Ross, R. J. M. (1989). Critically ill patients have high basal GH levels with low serum IGF-1, but similar mean 24 hour GH concentration compared to controls. Journal of Endocrinology Suppl. 123, 125.Google Scholar
Freeman, E., Touzel, R., Grossman, A., Besser, G. & Ross, R. J. M. (1990). Pyridostigmine an acetylcholinesterase inhibitor stimulates growth hormone release but has no effect on basal thyrotrophin or adrenocorticotrophin levels or the thyrotrophin response to thyrotrophin releasing hormone. Journal of Neuroendocrinology 2, 429–432.CrossRefGoogle ScholarPubMed
Frohman, L. A. & Jansson, J. O. (1986). Growth hormone-releasing hormone. Endocrine Reviews 7, 223–253.CrossRefGoogle ScholarPubMed
Garrel, D. R., Bajard, L., Harfouche, M. & Tourniaire, J. (1989). Effect of sustained hyperglycemia on GHRH induced GH secretion in man. Diabète et Métabolisme 15, 251–254.Google ScholarPubMed
Gelato, M. C., Pescovitz, O., Cassorla, F., Loriaux, D. L. & Merriam, G. R. (1983). Effects of a growth hormone releasing factor in man. Journal of Clinical Endocrinology and Metabolism 57, 674–676.Google Scholar
Gick, G. G. & Bancroft, C. (1987). Glucocorticoid stimulation of growth hormone messenger ribonucleic acid levels in GH3 cells is inhibited by calcium but not by somatostatin. Endocrinology 120, 1986–1990.Google Scholar
Graham, G. G., Cordano, A., Blizzard, R. M. & Cheek, D. B. (1969). Infantile malnutrition: changes in body composition during rehabilitation. Pediatric Research 3, 579–589.Google Scholar
Grant, D. B., Hambley, J., Becker, D. & Pimstone, B. L. (1973). Reduced sulphation factor in undernourished children. Archives of Disease in Childhood 48, 596–600.Google Scholar
Grossman, A. (1983). Brain opiates and neuroendocrine function. Journal of Clinical Endocrinology and Metabolism 12, 725–746.Google Scholar
Grossman, A., Savage, M. O., Wass, J. A. H., Lytras, N., Sueiras-Diaz, J., Coy, D. H. & Besser, G. M. (1983). Growth hormone-releasing factor in growth hormone deficiency: demonstration of a hypothalamic defect in growth hormone release. Lancet ii, 137–138.CrossRefGoogle Scholar
Guillemin, R., Brazeau, P., Bohlen, P., Esch, F., Ling, N. & Wehrenberg, W. B. (1982). Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science 218, 585–587.Google Scholar
Hagen, T. C., Lawrence, A. M. & Kirsteins, L. (1972). Autoregulation of growth hormone secretion in normal subjects. Metabolism 21, 603–610.Google Scholar
Hall, K. (1971). Effect of intravenous administration of human growth hormone on sulphation factor activity in serum of hypopituitary subjects. Acta Endocrinologica 66, 491–497.Google ScholarPubMed
Hall, K. & Sara, V. R. (1984). Somatomedin levels in childhood, adolescence and adult life. Journal of Clinical Endocrinology and Metabolism 13, 91–112.CrossRefGoogle ScholarPubMed
Hammer, R. E., Brinster, R. L., Rosenfeld, M. G., Evans, R. M. & Mayo, K. E. (1985). Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth. Nature 315, 413–416.Google Scholar
Ho, K. Y., Evans, W. S., Blizzard, R. M., Veldhuis, J. D., Merriam, G. R., Samojlik, E., Furlanetto, R., Rogol, A. D., Kaiser, D. L. & Thorner, M. O. (1987). Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentration. Journal of Clinical Endocrinology and Metabolism 64, 51–58.CrossRefGoogle Scholar
Ho, K. Y., Veldhuis, J. D., Johnson, M. L., Furlanetto, R., Evans, W. S., Alberti, K. G. M. M. & Thorner, M. O. (1988). Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. Journal of Clinical Investigation 81, 968–975.CrossRefGoogle ScholarPubMed
Imaki, T., Shibasaki, T., Masuda, A., Hotta, M., Yamauchi, N., Demura, H., Shizume, K., Wakabayashi, I. & Ling, N. (1986). The effect of glucose and free fatty acids on growth hormone (GH)-releasing factor-mediated GH secretion in rats. Endocrinology 118, 2390–2394.Google Scholar
Imaki, T., Shibasaki, T., Shizume, K., Masuda, A., Hotta, M., Kiyosawa, Y., Jibiki, K., Demura, H., Tsushima, T. & Ling, N. (1985) The effect of free fatty acids on growth hormone (GH)-releasing hormone-mediated GH secretion in primary hypothyroidism before and after treatment. Journal of Clinical Endocrinology and Metabolism 60, 290–293.CrossRefGoogle Scholar
Isaacs, R. E., Gardner, D. G. & Baxter, J. D. (1987). Insulin regulation of rat growth hormone gene expression. Endocrinology 120, 2022–2028.Google Scholar
Isaksson, O. G. P., Lindahl, A., Nilsson, A. & Isgaard, J. (1987). Mechanism of the stimulatory effect of growth hormone on longitudinal bone growth. Endocrine Reviews 8, 426–438.CrossRefGoogle ScholarPubMed
Iwatsubo, H., Omori, K., Okada, Y., Fukuchi, M., Miyai, K., Abe, H. & Kumahara, Y. (1967). Human growth hormone secretion in primary hypothyroidism before and after treatment. Journal of Clinical Endocrinology and Metabolism 27, 1751–1754.Google Scholar
Jordan, V., Dieguez, C., Lafaffian, I., Rodriguez-Arnao, M. D., Gomez-Pan, A., Hall, R. & Scanlon, M. F. (1986). Influence of dopaminergic adrenergic and cholinergic blockade and TRH administration on GH responses to GRF 1 29. Clinical Endocrinology 24, 291–298.Google Scholar
Katakami, H., Kato, Y., Matsushita, N. & Imura, H. (1984). Effects of neonatal treatment with monosodium glutamate on growth hormone release induced by clonidine and prostaglandin E1 in conscious male rats. Neuroendocrinology 38, 1–5.CrossRefGoogle ScholarPubMed
King, R. A., Smith, R. M. & Willoughby, J. O. (1986). Effects of sustained hyperglycemia on growth hormone secretion in free-moving rats. Hormone and Metabolic Research 18, 510–511.Google Scholar
Knopf, R. F., Conn, J. W., Fajans, S. S., Floyd, J. C., Guntsche, E. M. & Rull, J. A. (1965). Plasma growth hormone response to intravenous administration of amino acids. Journal of Clinical Endocrinology and Metabolism 25, 1140–1144.Google Scholar
Kopelman, P. G., Noonan, K., Goulton, R. & Forrest, A. J. (1985). Impaired growth hormone response to growth hormone releasing factor and insulin-hypoglycaemia in obesity. Clinical Endocrinology 23, 87–94.CrossRefGoogle ScholarPubMed
Krulich, L., Dhariwal, A. P. S. & McCann, S. M. (1968). Stimulatory and inhibitory effects of purified hypothalamic extracts on growth hormone release from rat pituitary in vitro. Endocrinology 83, 783–790.CrossRefGoogle ScholarPubMed
Lamberts, S. W. J., den Holder, F. & Hofland, L. J. (1989). The interrelationship between the effects of insulin-like growth factor I and somatostatin on growth hormone secretion by normal rat pituitary cells: the role of glucocorticoids. Endocrinology 124, 905–911.Google Scholar
Lanes, R. & Hurtado, E. (1982). Oral clonidine – an effective growth hormone-releasing hormone in healthy individuals. Journal of Clinical Endocrinology and Metabolism 65, 535–540.Google Scholar
Laron, Z., Hochman, I. H. & Keret, R. (1972). The effect of methandrostenolone on pituitary growth hormone secretion in prepubertal children. Clinical Endocrinology 1, 91–97.CrossRefGoogle ScholarPubMed
Lesniak, M. A., Hill, J. M., Kiess, W., Rojeski, M., Pert, C. B. & Roth, J. (1988). Receptors for insulin-like growth factors I and II: autoradiographic localization in rat brain and comparison to receptors for insulin. Endocrinology 123, 2089–2099.CrossRefGoogle ScholarPubMed
Letter (1990). Report on the nomenclature of the IGF binding proteins. Journal of Clinical Endocrinology and Metabolism 70, 817–818.Google Scholar
Leveston, S. A. & Cryer, P. E. (1980). Endogenous cholinergic modulation of growth-hormone secretion in normal and acromegalic humans. Metabolism 29, 703–706.CrossRefGoogle ScholarPubMed
Ling, N., Baird, A., Wehrenberg, W. B., Ueno, N., Munegumi, T., Chiang, T.-C., Regno, M. & Brazeau, P. (1984). Synthesis and in vitro bioactivity of human growth hormone-releasing factor analogs substituted at position- 1. Biochemical and Biophysical Research Communications 122, 304–310.Google Scholar
Locatelli, V., Torsello, A., Redaelli, M., Ghigo, E., Massara, F. & Müller, E. E. (1986). Cholinergic agonist and antagonist drugs modulate the growth hormone response to growth hormone-releasing hormone in the rat: evidence for mediation by somatostatin. Journal of Endocrinology 111, 271–278.CrossRefGoogle ScholarPubMed
Loche, S., Cappa, M., Borrelli, P., Faedda, A., Crinò, A., Cella, S. G., Corda, R., Müller, E. E. & Pintor, C. (1987). Reduced growth hormone response to growth hormone-releasing hormone in children with simple obesity: evidence for somatomedin-C mediated inhibition. Clinical Endocrinology 27, 145–153.CrossRefGoogle ScholarPubMed
Lumpkin, M. D., Samson, W. K. & McCann, S. M. (1985). Effects of intraventricular growth hormone-releasing factor on growth hormone release: further evidence for ultrashort loop feedback. Endocrinology 116, 2070–2074.Google Scholar
Maes, M., Underwood, L. E. & Ketelslegers, J.-M. (1986). Low serum somatomedin-C in insulin-dependent diabetes: evidence for a postreceptor mechanism. Endocrinology 118, 377–382.Google Scholar
Maiter, D., Fliesen, T., Underwood, L. E., Maes, M., Gerard, G., Davenport, M. L. & Ketelslegers, J. M. (1989). Dietary protein restriction decreases insulin like growth factor 1, independent of insulin and liver growth hormone binding. Endocrinology 124, 2604–2611.Google Scholar
Manson, J. M. & Wilmore, D. W. (1986). Positive nitrogen balance with human growth hormone and hypocaloric intravenous feeding. Surgery 100, 188–197.Google Scholar
Martha, P. M., Rogol, A. D., Veldhuis, J. D., Kerrigan, J. R., Goodman, D. W. & Blizzard, R. M. (1989). Alterations in the pulsatile properties of circulating growth hormone concentrations during puberty in boys. Journal of Clinical Endocrinology and Metabolism 69, 563–570.Google Scholar
Martin, J. B. (1976). Brain regulation of growth hormone secretion. In Frontiers in Neuroendocrinology, vol. 4, pp. 129–169 [Martini, L. and Ganong, W. F., editors]. New York: Raven Press.Google Scholar
Massara, F., Ghigo, E., Demislis, K., Tangolo, D., Mazza, E., Locatelli, V., Müller, E., Molinatti, G.-M. & Camanni, F. (1986). Cholinergic involvement in the growth hormone releasing hormone-induced growth hormone release: studies in normal and acromegalic subjects. Neuroendocrinology 43, 670–675.Google Scholar
Mayo, K. E., Cerelli, G. M., Lebo, R. V., Bruce, B. D., Rosenfeld, M. G. & Evans, R. M. (1985). Gene encoding human growth hormone-releasing factor precursor: structure, sequence, and chromosomal assignment. Proceedings of the National Academy of Sciences, USA 82, 63–68.CrossRefGoogle ScholarPubMed
Mendelson, W. B., Jacobs, L. S. & Gillin, J. C. (1983). Negative feedback suppression of sleep-related growth hormone secretion. Journal of Clinical Endocrinology and Metabolism 56, 486–488.Google Scholar
Merimee, T. J., Burgess, J. A. & Rabinowitz, D. (1966). Sex-determined variation in serum insulin and growth hormone response to amino acid stimulation. Journal of Clinical Endocrinology and Metabolism 26, 791–793.Google Scholar
Merimee, T. J., & Fineberg, S. E. (1971). Studies of the sex based variation of human growth hormone secretion. Journal of Clinical Endocrinology and Metabolism 33, 896–902.CrossRefGoogle ScholarPubMed
Merimee, T. J., Lillicrap, D. A. & Rabinowitz, D. (1965). Effect of arginine on serum-levels of human growth-hormone. Lancet ii, 668–670.CrossRefGoogle Scholar
Merimee, T. J., Rabinowitz, D. & Fineberg, S. E. (1969). Arginine-initiated release of human growth hormone. New England Journal of Medicine 280, 1434–1438.Google Scholar
Milner, R. D. G. (1971 a). Metabolic and hormonal responses to glucose and glucagon in patients with infantile malnutrition. Pediatric Research 5, 33–39.CrossRefGoogle Scholar
Milner, R. D. G. (1971 b). Metabolic and hormonal responses to oral amino acids in infantile malnutrition. Archives of Disease in Childhood 46, 301–305.Google Scholar
Minuto, F., Barreca, A., Adami, G. F., Fortini, P., Monte, P. D., Cella, F., Scopinaro, N. & Giordano, G. (1989). Insulin-like growth factor-1 in human malnutrition: relationship with some body composition and nutritional parameters. Journal of Parenteral and Enteral Nutrition 13, 392–396.Google Scholar
Mosier, H. D., Jansons, R. A. & Dearden, L. C. (1985). Increased secretion of growth hormone in rats undergoing catch-up growth after fasting. Growth 49, 346–353.Google Scholar
Nakagawa, K., Ishizuka, T., Obara, T., Matsubara, M. & Akikawa, K. (1987). Dichotomic action of glucocorticoids on growth hormone secretion. Acta Endocrinologica 116, 165–171.Google Scholar
Nakamoto, J. M., Gertner, J. M., Press, C. M., Hintz, R. L., Rosenfeld, R. G. & Genel, M. (1986). Suppression of the growth hormone (GH) response to clonidine and GH-releasing hormone by exogenous GH. Journal of Clinical Endocrinology and Metabolism 62, 822–826.Google Scholar
Namba, H., Morita, S. & Melmed, S. (1989). Insulin-like growth factor-I action on growth hormone secretion and messenger ribonucleic acid levels: interaction with somatostatin. Endocrinology 124, 1794–1799.CrossRefGoogle ScholarPubMed
Netti, C., Guidobono, F., Olgiati, V. R., Sibilia, V. & Pecile, A. (1981). Histamine agonist and antagonist drugs: interference with CNS control of GH release in rats. Hormone Research 14, 180–191.Google Scholar
Ocrant, I., Valentino, K. L., Hoffman, A. R., Hintz, R. L., Wilson, D. L. & Rosenfeld, R. G. (1989). Structural characterization and immunohistochemical localization of receptors for insulin-like growth factor II in the rat pituitary gland. Neuroendocrinology 49, 248–254.Google Scholar
O'Sullivan, U., Gluckman, P. D., Breier, B. H., Woodall, S., Siddiqui, R. A. & McCutcheon, S. N. (1989). Insulin-like growth factor-1 (IGF-1) in mice reduces weight loss during starvation. Endocrinology 125, 2793–2796.CrossRefGoogle ScholarPubMed
Peters, J. R., Evans, P. J., Page, M. D., Hall, R., Gibbs, J. T., Dieguez, C. & Scanlon, M. F. (1986). Cholinergic muscarinic receptor blockade with pirenzepine abolishes slow wave sleep-related growth hormone release in normal adult males. Clinical Endocrinology 25, 213–217.Google Scholar
Phillips, L. S. (1986). Nutrition, somatomedins and the brain. Metabolism 35, 78–87.CrossRefGoogle ScholarPubMed
Phillips, L. S. & Unterman, T. G. (1984). Somatomedin activity in disorders of nutrition and metabolism. Clinics in Endocrinology and Metabolism 13, 145–189.Google Scholar
Pimstone, B., Barbezat, G., Hansen, J. D. L. & Murray, P. (1967). Growth hormone and protein-calorie malnutrition. Impaired suppression during induced hyperglycaemia. Lancet ii, 1333–1334.Google Scholar
Pimstone, B. L., Barbezat, G., Hansen, J. D. L. & Murray, P. (1968). Studies on growth hormone secretion in protein-calorie malnutrition. American Journal of Clinical Nutrition 21, 482–487.Google Scholar
Pimstone, B. L., Becker, D. & Kronheim, S. (1975). Disappearance of plasma growth hormone in acromegaly and protein calorie malnutrition after somatostatin. Journal of Clinical Endocrinology and Metabolism 40, 168–171.Google Scholar
Pimstone, B. L., Wittmann, W., Hansen, J. D. L. & Murray, P. (1966). Growth hormone and kwashiorkor. Role of protein in growth-hormone homeostasis. Lancet ii, 779–780.CrossRefGoogle Scholar
Plotsky, P. M. & Vale, W. (1985). Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat. Science 230, 461–463.Google Scholar
Press, M., Tamborlane, W. V., Thorner, M. O., Vale, W., Rivier, J., Gertner, J. M. & Sherwin, R. S. (1984). Pituitary response to growth hormone-releasing factor in diabetes: failure of glucose-mediated suppression. Diabetes 33, 804–806.CrossRefGoogle ScholarPubMed
Quabbe, H.-J., Schilling, E. & Helge, H. (1966). Pattern of growth hormone secretion during a 24-hour fast in normal adults. Journal of Clinical Endocrinology and Metabolism 26, 1173–1177.Google Scholar
Reichlin, S. (1961). Growth hormone content of pituitaries from rats with hypothalamic lesions. Endocrinology 69, 225–230.Google Scholar
Reichlin, S. (1983 a). Somatostatin: Part I. New England Journal of Medicine 309, 1495–1502.Google Scholar
Reichlin, S. (1983 b). Somatostatin: Part II. New England Journal of Medicine 309, 1556–1563.Google Scholar
Richardson, S. B., Hollander, C. S., D'Eletto, R., Greenleaf, P. W. & Thaw, C. (1980). Acetylcholine inhibits the release of somatostatin from rat hypothalamus in vitro. Endocrinology 107, 122–129.Google Scholar
Rinderknecht, E. & Humbel, R. E. (1978 a). The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. Journal of Biological Chemistry 253, 2769–2776.Google Scholar
Rinderknecht, E. & Humbel, R. E. (1978 b). Primary structure of human insulin-like growth factor II. FEBS Letters 89, 283–286.Google Scholar
Rivier, J., Spiess, J., Thorner, M. & Vale, W. (1982). Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour. Nature 300, 276–278.Google Scholar
Rosenbaum, M., Fong, Y., Hesse, D. G., Tracey, K. J., Hintz, R. L., Lowry, S. F. & Gertner, J. M. (1989). Intravenous refeeding blocks growth hormone (GH)-provoked rises in serum free fatty acids and blunting of somatotroph response to GH-releasing hormone in normal men. Journal of Clinical Endocrinology and Metabolism 69, 310–316.Google Scholar
Rosenthal, S. M., Hulse, J. A., Kaplan, S. L. & Grumbach, M. M. (1986). Exogenous growth hormone inhibits growth hormone-releasing factor-induced growth hormone secretion in normal men. Journal of Clinical Investigation 77, 176–180.CrossRefGoogle ScholarPubMed
Rosenthal, S. M., Schriock, E. A., Kaplan, S. L., Guillemin, R. & Grumbach, M. M. (1983). Synthetic human pancreas growth hormone-releasing factor (hpGRF1 44-NH2) stimulates growth hormone secretion in normal men. Journal of Clinical Endocrinology and Metabolism 57, 677–679.Google Scholar
Ross, R. J. M., Borges, F., Grossman, A., Smith, R., Nhagafoong, L., Rees, L. H., Savage, M. O. & Besser, G. M. (1987 a). Growth hormone pretreatment in man blocks the response to growth hormone-releasing hormone: evidence for a direct effect of growth hormone. Clinical Endocrinology 26, 117–123.Google Scholar
Ross, R. J. M., Buchanan, C. R., Holly, J., Jones, J., Freeman, E. & Preece, M. A. (1990). Critically ill patients with low serum IGF-1 and insulin resistance retain the inverse relationship between IGF-Binding Protein-1 (IGF-BPI) and Insulin. Journal of Endocrinology Suppl. 123, 127.Google Scholar
Ross, R. J. M., Grossman, A., Davies, P. S. W., Savage, M. O. & Besser, G. M. (1987 b). Stilboestrol pretreatment of children with short stature does not effect the growth hormone response to growth hormone-releasing hormone. Clinical Endocrinology 27, 155–161.Google Scholar
Ross, R. J. M., Tsagarakis, S., Grossman, A., Nhagafoong, L., Touzel, R. J., Rees, L. H. & Besser, G. M. (1987 c). GH feedback occurs through modulation of hypothalamic somatostatin under cholinergic control; studies with pyridostigmine and GHRH. Clinical Endocrinology 27, 727–733.Google Scholar
Rosskamp, R., Becker, M., Haverkamp, F., Thomas, B., Brühl, S., Klumpp, J. & Liappis, N. (1987 a). Plasma levels of growth hormone-releasing hormone and somatostatin in response to a mixed meal and during sleep in children. Acta Endocrinologica 116, 549–554.Google Scholar
Rosskamp, R., Becker, M. & Soetadji, S. (1987 b). Circulating somatomedin-C levels and the effect of growth hormone-releasing factor on plasma levels of growth hormone and somatostatin-like immunoreactivity in obese children. European Journal of Pediatrics 146, 48–50.Google Scholar
Rosskamp, R., Mallmann, R., Liappis, R. & Soetadjii, S. (1987 c). Circulating serum phenylalanine concentrations and the effect of arginine infusion on plasma levels of growth hormone and insulin in treated phenylketonuric children. Acta Endocrinologica 114, 483–487.Google Scholar
Rudman, D., Kutner, M. H., Blackston, R. D., Cushman, R. A., Bain, R. P. & Patterson, J. H. (1981). Children with normal-variant short stature: treatment with human growth hormone for six months. New England Journal of Medicine 305, 123–131.Google Scholar
Salmon, W. D. & Daughaday, W. H. (1957). Hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. Journal of Laboratory and Clinical Medicine 49, 825–836.Google Scholar
Sartin, J. L., Bartol, F. F., Kemppainen, R. J., Dieberg, G., Buxton, D. & Soyoola, E. (1988). Modulation of growth hormone-releasing factor stimulated growth hormone secretion by plasma glucose and free fatty acid concentrations in sheep. Neuroendocrinology 48, 627–633.Google Scholar
Scanes, C. G., Griminger, P. & Buonomo, F. C. (1981). Effects of dietary protein restriction on circulating concentrations of growth hormone in growing domestic fowl (Gallus domesticus). Proceedings of the Society for Experimental Biology and Medicine 168, 334–337.Google Scholar
Schlecter, N. L., Russell, S. M., Spencer, E. M. & Nicoll, C. S. (1986). Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin. Proceedings of the National Academy of Sciences, USA 83, 7932–7934.Google Scholar
Shapiro, B. & Pimstone, B. L. (1978). Sulphation factor (somatomedin activity) in experimental protein malnutrition in the rat. Journal of Endocrinology 77, 233–240.Google Scholar
Sharp, P. S., Foley, K., Chahal, P. & Kohner, E. M. (1984). The effect of plasma glucose on the growth hormone response to human pancreatic growth hormone releasing factor in normal subjects. Clinical Endocrinology 20, 497–501.Google Scholar
Sheppard, M. C., Kronheim, S. & Pimstone, B. L. (1978). Stimulation by growth hormone of somatostatin release from the rat hypothalamus in vitro. Clinical Endocrinology 9, 583–586.CrossRefGoogle ScholarPubMed
Shibasaki, T., Hotta, M., Masuda, A., Imaki, T., Obara, N., Demura, H., Ling, N. & Shizume, K. (1985). Plasma GH responses to GHRH and insulin-induced hypoglycemia in man. Journal of Clinical Endocrinology and Metabolism 60, 1265–1267.Google Scholar
Snyder, D. K., Clemmons, D. R. & Underwood, L. E. (1989). Dietary carbohydrate content determines responsiveness to growth hormone in energy-restricted humans. Journal of Clinical Endocrinology and Metabolism 69, 745–752.Google Scholar
Soliman, A. T., Hassan, A. E. I., Aref, M. K., Hintz, R. L., Rosenfeld, R. G. & Rogol, A. D. (1986). Serum insulin-like growth factor-1 and factor-2 concentrations and growth hormone and insulin responses to arginine infusion in children with protein energy malnutrition before and after nutritional rehabilitation. Pediatric Research 20, 1122–1130.Google Scholar
Sopwith, A. M., Penny, E. S., Besser, G. M. & Rees, L. H. (1985). Stimulation by food of peripheral plasma immunoreactive growth hormone releasing factor. Clinical Endocrinology 22, 337–340.Google Scholar
Sopwith, A. M., Penny, E. S., Grossman, A., Savage, M. O., Besser, G. M. & Rees, L. H. (1986). Normal circulating immunoreactive growth hormone releasing factor (hGRF) concentrations in patients with functional hypothalamic hGRF deficiency. Clinical Endocrinology 24, 395–400.Google Scholar
Sopwith, A. M., Penny, E. S., Lytras, N., Besser, G. M. & Rees, L. H. (1987). Dissociation between circulating concentrations of immunoreactive growth hormone releasing factor and growth hormone in normal human subjects. Clinical Science 72, 181–185.Google Scholar
Stubbs, W. A., Delitala, G., Jones, A., Jeffcoate, W. J., Edwards, C. R. W., Ratter, S. J., Besser, G. M., Bloom, S. R. & Alberti, K. G. M. M. (1978). Hormonal and metabolic responses to an enkephalin analogue in normal man. Lancet ii, 1225–1227.CrossRefGoogle Scholar
Sukkar, M. Y., Hunter, W. M. & Passmore, R. (1967). Changes in plasma levels of insulin and growth-hormone levels after a protein meal. Lancet ii, 1020–1022.Google Scholar
Takahashi, Y., Kipnis, D. M. & Daughaday, W. H. (1968). Growth hormone secretion during sleep. Journal of Clinical Investigation 47, 2079–2090.Google Scholar
Tannenbaum, G. S. (1980). Evidence for autoregulation of growth hormone secretion via the central nervous system. Endocrinology 107, 2117–2120.Google Scholar
Tannenbaum, G. S., Guyda, H. J. & Posner, B. I. (1983). Insulin-like growth factors: a role in growth hormone negative feedback and body weight regulation via brain. Science 220, 77–79.Google Scholar
Tannenbaum, G. S. & Ling, N. (1984). The interrelationship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm of GH secretion. Endocrinology 115, 1952–1957.Google Scholar
Tannenbaum, G. S., Rorstad, O. & Brazeau, P. (1979). Effects of prolonged food deprivation on the ultradian growth hormone rhythm and immunoreactive somatostatin tissue levels in the rat. Endocrinology 104, 1733–1738.Google Scholar
Tatár, P. & Vigaš, M. (1984). Role of alpha1- and alpha2-adrenergic receptors in the growth hormone and prolactin response to insulin-induced hypoglycemia in man. Neuroendocrinology 39, 275–280.Google Scholar
Taylor, A. M., Dunger, D. B., Preece, M. A., Holly, J. M. P., Smith, C. P., Wass, J. A. H., Patel, S. & Tate, V. E. (1990). The growth hormone independent insulin-like growth factor- 1 binding protein BP-28 is associated with serum insulin-like growth factor- 1 inhibitory bioactivity in adolescent insulin-dependent diabetics. Clinical Endocrinology 32, 229–239.Google Scholar
Terry, L. C. & Martin, J. B. (1981). The effects of lateral hypothalamic-medial forebrain stimulation and somatostatin antiserum on pulsatile growth hormone secretion in freely behaving rats: evidence for a dual regulatory mechanism. Endocrinology 109, 622–627.Google Scholar
Thorner, M. O. & Vance, M. L. (1988). Growth hormone 1988. Journal of Clinical Investigation 82, 745–747.Google Scholar
Unger, R. H., Eisentraut, A. M., Madison, L. L. & Siperstein, M. D. (1965). Fasting levels of growth hormone in men and women. Nature 205, 804–805.Google Scholar
Vance, M. L., Kaiser, D. L., Evans, W. S., Furlanetto, R., Vale, W., Rivier, J. & Thorner, M. O. (1985). Pulsatile growth hormone secretion in normal man during a continuous 24-hour infusion of human growth hormone releasing factor (1–40). Evidence for intermittent somatostatin secretion. Journal of Clinical Investigation 75, 1584–1589.Google Scholar
Ward, H. C., Halliday, D. & Sim, A. J. W. (1987). Protein and energy metabolism with biosynthetic human growth hormone after gastrointestinal surgery. Annals of Surgery 206, 56–61.Google Scholar
Waters, M. J., Barnard, R. T., Lobie, P. E., Lim, L., Hamlin, G., Spencer, S. A., Hammonds, R. G., Leung, D. W. & Wood, W. I. (1990). Growth hormone receptors – their structure, location and role. Acta Paediatrica Scandinavica Suppl. 366, 60–72.Google Scholar
Wehrenberg, W. B., Brazeau, P., Luben, R., Böhlen, P. & Guillemin, R. (1982 a). Inhibition of the pulsatile secretion of growth hormone by monoclonal antibodies to the hypothalamic growth hormone releasing factor (GRF). Endocrinology 111, 2147–2148.Google Scholar
Wehrenberg, W. B., Ling, N., Böhlen, P., Esch, F., Brazeau, P. & Guillemin, R. (1982 b). Physiological roles of somatocrinin and somatostatin in the regulation of growth hormone secretion. Biochemical and Biophysical Research Communications 109, 562–567.Google Scholar
Wight, P. A., Crew, M. D. & Spindler, S. R. (1987). Discrete positive and negative thyroid hormone-responsive transcription regulatory elements of the rat growth hormone gene. Journal of Biological Chemistry 262, 5659–5663.CrossRefGoogle ScholarPubMed
Williams, T., Berelowitz, M., Joffe, S. N., Thorner, M. O., Rivier, J., Vale, W. & Frohman, L. A. (1984). Impaired growth hormone responses to growth hormone-releasing factor in obesity: a pituitary defect reversed with weight reduction. New England Journal of Medicine 311, 1403–1407.Google Scholar
Yamashita, S. & Melmed, S. (1986). Insulin regulation of rat growth hormone gene transcription. Journal of Clinical Investigation 78, 1008–1014.Google Scholar
Yeoh, S. I. & Baxter, R. C. (1988). Metabolic regulation of the growth hormone independent insulin-like growth factor binding protein in human plasma. Acta Endocrinologica 119, 465–473.Google Scholar
Ziegler, T. R., Young, L. S., Manson, J. McK. & Wilmore, D. W. (1988). Metabolic effects of recombinant human growth hormone in patients receiving parenteral nutrition. Annals of Surgery 208, 6–16.Google Scholar