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The effect of boarfish protein hydrolysate on postprandial glycaemic response and satiety in healthy adults

Published online by Cambridge University Press:  06 September 2018

W. Crowe ,
C.M. McLaughlin ,
P.J. Allsopp ,
M.M. Slevin ,
P.A. Harnedy ,
Y. Cassidy ,
J. Baird ,
M. Devaney ,
R.J. Fitzgerald  and
F.P.M. O'Harte
...Show all authors
W. Crowe
Affiliation:
Nutrition Innovation Centre for Food and Health, School of Biomedical Sciences, Ulster University, Coleraine, Co. Derry, BT52 1SA, Ireland
C.M. McLaughlin
Affiliation:
The SAAD Centre for Pharmacy & Diabetes, School of Biomedical Sciences, Ulster University, Coleraine, Co. Derry, BT52 1SA, Ireland
P.J. Allsopp
Affiliation:
Nutrition Innovation Centre for Food and Health, School of Biomedical Sciences, Ulster University, Coleraine, Co. Derry, BT52 1SA, Ireland
M.M. Slevin
Affiliation:
Nutrition Innovation Centre for Food and Health, School of Biomedical Sciences, Ulster University, Coleraine, Co. Derry, BT52 1SA, Ireland
P.A. Harnedy
Affiliation:
Department of Biological Sciences, University of Limerick, Limerick, Ireland
Y. Cassidy
Affiliation:
Nutrition Innovation Centre for Food and Health, School of Biomedical Sciences, Ulster University, Coleraine, Co. Derry, BT52 1SA, Ireland
J. Baird
Affiliation:
Nutrition Innovation Centre for Food and Health, School of Biomedical Sciences, Ulster University, Coleraine, Co. Derry, BT52 1SA, Ireland
M. Devaney
Affiliation:
Nutrition Innovation Centre for Food and Health, School of Biomedical Sciences, Ulster University, Coleraine, Co. Derry, BT52 1SA, Ireland
R.J. Fitzgerald
Affiliation:
Department of Biological Sciences, University of Limerick, Limerick, Ireland
F.P.M. O'Harte
Affiliation:
The SAAD Centre for Pharmacy & Diabetes, School of Biomedical Sciences, Ulster University, Coleraine, Co. Derry, BT52 1SA, Ireland
E.M. McSorley
Affiliation:
Nutrition Innovation Centre for Food and Health, School of Biomedical Sciences, Ulster University, Coleraine, Co. Derry, BT52 1SA, Ireland
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Abstract

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There have been increased efforts to find an added-value application for the currently underutilised pelagic fish species, Boarfish (Capros aper)(Reference Hayes, Mora, Hussey and Aluko1). Recent in vitro and in vivo research has demonstrated that fish protein hydrolysate (BPH) has a beneficial effect on glycaemic control and reduced food intake(Reference Harnedy, Parthsarathy and McLaughlin2). This study aims to investigate the effect of consuming boarfish on postprandial glycaemic control in human participants.

A randomised controlled human intervention crossover study was undertaken in a cohort of healthy adults (n = 20) to investigate the effect of consuming a BPH (3·5 g) drink on postprandial glycaemic control in comparison to a control drink. Blood samples were collected before (0 mins) and after the test drink was consumed over a 3-hour period (15, 30, 60, 90,120 and 180 mins). Collected blood samples were analysed for biomarkers of satiety (ghrelin, leptin) and glycaemic control (glucose, insulin, glucagon-like peptide 1 (GLP-1)). Visual analogue scales (VAS) were completed at each time point by participants to provide a subjective measure of their satiety.

Paired T test analysis revealed no significant difference between the area under the curve (AUC) for insulin or glucose, when the effect of BPH consumption was compared to the standard drink. A significant increase in satiety rating by 11·1% at 180 minutes (P = 0·034) was reported following BPH consumption in comparison to the control drink (Fig. 1).

Fig. 1.

Subjective hunger ratings over 3 hours by participants consuming boarfish protein hydrolysate and control.

This study showed that consuming 3·5 g of BPH had no effect on biomarkers of satiety or glycaemic control, albeit a higher dose may be required to see an effect. The BPH may have satiating effects which warrant further investigation.

References

1.Hayes, M, Mora, L, Hussey, K, Aluko, RE (2016) Innov Food Sci Emerg Technol 37, 253–60.Google Scholar
2.Harnedy, PA, Parthsarathy, V, McLaughlin, CM et al. (2018) J Func Foods 40, 137–45.Google Scholar
Figure 0

Fig. 1. Subjective hunger ratings over 3 hours by participants consuming boarfish protein hydrolysate and control.