Is the Antidepressant Efficacy of Ketamine and Esketamine Mediated via Opioid Mechanisms?

Andy Lu: Affiliation:
Department of Psychology, University of Western Ontario, London, ON, Canada Brain and Cognition Discovery Foundation, Toronto, ON, Canada
Heidi Xu: Affiliation:
Brain and Cognition Discovery Foundation, Toronto, ON, Canada Department of Toxicology and Neuroscience, University of Toronto, Toronto, ON, Canada
Gia Han Le: Affiliation:
Brain and Cognition Discovery Foundation, Toronto, ON, Canada Institute of Medical Science, University of Toronto, Toronto, ON, Canada Poul Hansen Family Centre for Depression, University Health Network, Toronto, ON, Canada
Christine E. Dri: Affiliation:
Brain and Cognition Discovery Foundation, Toronto, ON, Canada
Sabrina Wong: Affiliation:
Brain and Cognition Discovery Foundation, Toronto, ON, Canada Poul Hansen Family Centre for Depression, University Health Network, Toronto, ON, Canada Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
Roger Ho: Affiliation:
Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore Division of Life Science (LIFS), Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Hong Kong.
Bing Cao: Affiliation:
Key Laboratory of Cognition and Personality, Faculty of Psychology, Ministry of Education, Southwest University, Chongqing, 400715, P. R. China
Heidi Ka Ying Lo: Affiliation:
Department of Psychiatry, School of Clinical Medicine, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong
Taeho Greg Rhee: Affiliation:
Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA Department of Public Health Sciences, University of Connecticut School of Medicine, Farmington, CT, USA
Liyang Yin: Affiliation:
Brain and Cognition Discovery Foundation, Toronto, ON, Canada
Hernan F. Guillen-Burgos: Affiliation:
Pontificia Universidad Javeriana, Department of Psychiatry and Mental Health, Bogota DC, Colombia Center for Clinical and Translational Research, Bogota DC, Colombia Universidad Simón Bolívar, Center for Clinical and Translational Research, Barranquilla, Colombia
Roger S McIntyre*: Affiliation:
Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
*: *Corresponding Author: Dr. Roger S. McIntyre, Brain and Cognition Discovery Foundation, 77 Bloor Street West, Suite 617, Toronto, ON, M5S 1M2, Canada. Email: roger.mcintyre@bcdf.org

Article contents

Abstract

Abstract

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Keywords

Ketamine Esketamine Receptors, Opioid Depressive Disorder, Treatment-Resistant Depressive Disorder, Major

Information

Type: Review/Meta-analysis
Information: European Psychiatry , Accepted manuscript , pp. 1 - 42

DOI: https://doi.org/10.1192/j.eurpsy.2026.10157 [Opens in a new window]
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