Hostname: page-component-89b8bd64d-shngb Total loading time: 0 Render date: 2026-05-07T15:09:18.236Z Has data issue: false hasContentIssue false
  • English
  • Français

Addenbrooke's cognitive examination III: diagnostic utility for mild cognitive impairment and dementia and correlation with standardized neuropsychological tests

Published online by Cambridge University Press:  29 September 2016

Jordi A. Matias-Guiu ,
Ana Cortés-Martínez ,
Maria Valles-Salgado ,
Teresa Rognoni ,
Marta Fernández-Matarrubia ,
Teresa Moreno-Ramos  and
Jorge Matías-Guiu
Jordi A. Matias-Guiu*
Affiliation:
Department of Neurology, Hospital Clínico San Carlos, San Carlos Institute for Health Research (IdISSC), Universidad Complutense de Madrid, Madrid, Spain
Ana Cortés-Martínez
Affiliation:
Department of Neurology, Hospital Clínico San Carlos, San Carlos Institute for Health Research (IdISSC), Universidad Complutense de Madrid, Madrid, Spain
Maria Valles-Salgado
Affiliation:
Department of Neurology, Hospital Clínico San Carlos, San Carlos Institute for Health Research (IdISSC), Universidad Complutense de Madrid, Madrid, Spain
Teresa Rognoni
Affiliation:
Department of Neurology, Hospital Clínico San Carlos, San Carlos Institute for Health Research (IdISSC), Universidad Complutense de Madrid, Madrid, Spain
Marta Fernández-Matarrubia
Affiliation:
Department of Neurology, Hospital Clínico San Carlos, San Carlos Institute for Health Research (IdISSC), Universidad Complutense de Madrid, Madrid, Spain
Teresa Moreno-Ramos
Affiliation:
Department of Neurology, Hospital Clínico San Carlos, San Carlos Institute for Health Research (IdISSC), Universidad Complutense de Madrid, Madrid, Spain
Jorge Matías-Guiu
Affiliation:
Department of Neurology, Hospital Clínico San Carlos, San Carlos Institute for Health Research (IdISSC), Universidad Complutense de Madrid, Madrid, Spain
*
Correspondence should be addressed to: Jordi A. Matias-Guiu, Department of Neurology, Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdISSC), Universidad Complutense, Calle Profesor Martin Lagos S/N, 28040, Madrid, Spain. Phone: +34676933312, +34913303511. Email: jordimatiasguiu@hotmail.com, jordi.matias-guiu@salud.madrid.org.
Get access

Abstract

Background:

Addenbrooke's Cognitive Examination III (ACE-III) is a screening test that was recently validated for diagnosing dementia. Since it assesses attention, language, memory, fluency, and visuospatial function separately, it may also be useful for general neuropsychological assessments. The aim of this study was to analyze the tool's ability to detect early stages of Alzheimer's disease and to examine the correlation between ACE-III scores and scores on standardized neuropsychological tests.

Methods:

Our study included 200 participants categorized as follows: 25 healthy controls, 48 individuals with subjective memory complaints, 47 patients with amnestic mild cognitive impairment and 47 mild Alzheimer's disease, and 33 patients with other neurodegenerative diseases.

Results:

The ACE-III memory and language domains were highly correlated with the neuropsychological tests specific to those domains (Pearson correlation coefficient of 0.806 for total delayed recall on the Free and Cued Selective Reminding Test vs. 0.744 on the Boston Naming Test). ACE-III scores discriminated between controls and patients with amnestic mild cognitive impairment (AUC: 0.906), and between controls and patients with mild Alzheimer's disease (AUC: 0.978).

Conclusion:

Our results suggest that ACE-III is a useful neuropsychological test for assessing the cognitive domains of attention, language, memory, and visuospatial function. It also enables detection of Alzheimer's disease in early stages.

Keywords

Addenbrooke's cognitive examinationcognitive screeningdementianeuropsychological assessmentAlzheimer's disease

Information

Type
Research Article
Information
International Psychogeriatrics , Volume 29 , Issue 1 , January 2017 , pp. 105 - 113
Copyright
Copyright © International Psychogeriatric Association 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Blesa, R. et al. (2001). Clinical validity of the “mini-mental state” for Spanish speaking communities. Neuropsychologia, 39, 1150–1157.CrossRefGoogle ScholarPubMed
Crawford, S., Whitnall, L., Robertson, J. and Evans, J. J. (2012). A systematic review of the accuracy and clinical utility of the Addenbrooke's cognitive examination and the Addenbrooke's cognitive examination-revised in the diagnosis of dementia. International Journal of Geriatric Psychiatry, 27, 659–669.CrossRefGoogle ScholarPubMed
DeLong, E. R., DeLong, D. M. and Clarke-Pearson, D. L. (1988). Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics, 44, 837–844.Google Scholar
Elamin, M., Holloway, G., Bak, T. H. and Pal, S. (2015). The utility of the Addenbrooke's cognitive examination version three in early-onset dementia. Dementia and Geriatric Cognitive Disorders, 41, 9–15.Google Scholar
Gorno-Tempini, M. L. et al. (2011). Classification of primary progressive aphasia and its variants. Neurology, 76, 1006–1114.Google Scholar
Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery, and Psychiatry, 23, 56–62.Google Scholar
Hsieh, S. et al. (2015). The mini-Addenbrooke's cognitive examination: a new assessment tool for dementia. Dementia and Geriatric Cognitive Disorders, 39, 1–11.Google Scholar
Hsieh, S., Schubert, S., Hoon, C., Mioshi, E. and Hodges, J. R. (2013). Validation of the Addenbrooke's cognitive examination III in frontotemporal dementia and Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 36, 242–250.CrossRefGoogle ScholarPubMed
Jubb, M. and Evans, J. J. (2015). An investigation of the utility of the Addenbrooke's cognitive examination III in the early detection of dementia in memory clinic patients aged over 75 years. Dementia and Geriatric Cognitive Disorders, 40, 222–232.CrossRefGoogle ScholarPubMed
Lam, B. et al. (2013). Criterion and convergent validity of the montreal cognitive assessment with screening and standardized neuropsychological testing. Journal of the American Geriatrics Society, 61, 2181–2185.Google Scholar
Larner, A. and Mitchell, A. J. (2014). A meta-analysis of the accuracy of the Addenbrooke's cognitive examination (ACE) and the Addenbrooke's cognitive examination-revised (ACE-R) in the detection of dementia. International Psychogeriatrics, 26, 555–563.Google Scholar
Leyton, C. E., Hornberger, M., Mioshi, E. and Hodges, J. R. (2010). Application of Addenbrooke's cognitive examination to diagnosis and monitoring of progressive primary aphasia. Dementia and Geriatric Cognitive Disorders, 29, 504–509.Google Scholar
Litvan, I. et al. (1996). Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Ricardson-Olszewski syndrome): report of the NINS-SPSP international workshop. Neurology, 47, 1–9.Google Scholar
Mathuranath, P. S., Nestor, P. J., Berrios, G. E., Rakowicz, W. and Hodges, J. R. (2000). A brief cognitive test battery to differentiate Alzheimer's disease and frontotemporal dementia. Neurology, 55, 1613–1620.CrossRefGoogle ScholarPubMed
Matias-Guiu, J. A. et al. (2014). Evaluation of the new consensus criteria for the diagnosis of primary progressive aphasia using fluorodeoxyglucose positron emission tomography. Dementia and Geriatric Cognitive Disorders, 38, 147–152.CrossRefGoogle ScholarPubMed
Matías-Guiu, J. A. and Fernández-Bobadilla, R. (2014). Validation of the Spanish-language version of Mini-Addenbrooke's cognitive examination as a dementia screening tool. Neurología. doi:10.1016/j.nrl.2014.10.005.Google Scholar
Matías-Guiu, J. A., Fernández-Bobadilla, R. and Cortés-Martínez, A. (2016a). Addenbrooke's Cognitive Examination III: a neuropsychological test useful to screen and obtain a cognitive profile. Neurología. Epub ahead of print. doi: 10.1016/j.nrl.2016.06.014.Google Scholar
Matías-Guiu, J. A. et al. (2016b). Normative data for the Spanish version of the Addenbrooke's cognitive examination III. Dementia and Geriatric Cognitive Disorders, 41, 243–250.Google Scholar
Matías-Guiu, J. A. et al. (2015). Validation of the Spanish version of Addenbrooke's cognitive examination III for diagnosing dementia. Neurología, 30, 545–551.Google Scholar
McKeith, I. G. et al. (2005). Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium. Neurology, 65, 1863–1872.CrossRefGoogle ScholarPubMed
McKhann, G. et al. (2011). The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia, 7, 263–269.Google Scholar
Menon, R., Lekha, V., Justus, S., Sarma, P. and Mathuranath, P. (2014). A pilot study on utility of Malayalam version of Addenbrooke's cognitive examination in detection of amnestic mild cognitive impairment: a critical insight into utility of learning and recall measures. Annals of Indian Academy of Neurology, 17, 420–425.Google Scholar
Morris, J. C. (1993). The clinical dementia rating (CDR): current version and scoring rules. Neurology, 43, 2412–2414.CrossRefGoogle ScholarPubMed
Pedro, M. C., Mercedes, M. P., Ramón, L. H. and Borja, M. R. (2016). Subjective memory complaints in elderly: relationship with health status, multimorbidity, medications, and use of services in a population-based study. International Psychogeriatrics. Epub ahead of print. doi: 10.1017/S104161021600106X.CrossRefGoogle ScholarPubMed
Peña-Casanova, J. et al. (2009). Spanish multicenter normative studies (NEURONORMA project): methods and sample characteristics. Archives of Clinical Neuropsychology, 24, 307–319.Google Scholar
Pfeffer, R. I., Kurosaki, T. T., Harrah, C. H. Jr., Chance, J. M. and Filos, S. (1982). Measurement of functional activities in older adults in the community. The Journal of Gerontology, 37, 323–329.Google Scholar
Pigliautile, M. et al. (2011). Validation study of the Italian Addenbrooke's cognitive examination revised in a young-old and old-old population. Dementia and Geriatric Cognitive Disorders, 32, 301–307.Google Scholar
Rascovsky, K. et al. (2011). Sensitivity of revised diagnostic criteria for the behavioral variant of frontotemporal dementia. Brain, 134, 2456–2477.Google Scholar
Sarazin, M. et al. (2007). Amnestic syndrome of the medial temporal type identifies prodromal AD: a longitudinal study. Neurology, 69, 1859–1867.CrossRefGoogle ScholarPubMed
Supplementary material: File

Matias-Guiu supplementary material

Table S1

Download Matias-Guiu supplementary material(File)
File 128.4 KB