Hostname: page-component-848d4c4894-2pzkn Total loading time: 0 Render date: 2024-05-18T05:15:09.127Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of lactobacillus gaseeri THT 031301 supplementation on the body composition and inflammation in adults: pilot study

Published online by Cambridge University Press:  06 May 2021

H. Hamdallah ,
D. Lucas ,
B. Kestecher  and
N. Abdel Azim
H. Hamdallah
Affiliation:
Chester Medical School, University of Chester, Chester, UK
D. Lucas
Affiliation:
Faculty of Health, Liverpool John Moores University, Liverpool, UK
B. Kestecher
Affiliation:
Faculty of Medicine, Semmelweis University, Budapest, Hungary
N. Abdel Azim
Affiliation:
Chester Medical School, University of Chester, Chester, UK
Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content. As you have access to this content, full HTML content is provided on this page. A PDF of this content is also available in through the ‘Save PDF’ action button.
Type
Abstract
Information
Proceedings of the Nutrition Society , Volume 80 , Issue OCE2: Spring Conference, 29–30 March 2021, Gut microbiome and health , 2021 , E65
Check for updates
Copyright
Copyright © The Authors 2021

Human guts are occupied with 100–1000 microbial species which plays a significant role in the host health and disease(Reference Kerry, Patra and Gouda1). Lactobacillus species have shown a paradoxical effect in relation to body composition. Clinical trials using lactobacillus gasseri (L. gasseri) have demonstrated an anti-obesity effect, exhibiting significant reductions in visceral and subcutaneous fat, body weight, body mass index (BMI), and waist and hip circumferences(Reference Olivares, Díaz-Ropero and Gómez2). Moreover, L. gasseri has contributed to the regulation of abdominal obesity and showed a potential immunomodulatory effect in infants as well as boosting the immune system of healthy adults(Reference Oh, Joung, Lee and Kim3, Reference Kadooka, Sato and Imaizumi4). Rodent models have found an association between the presence of L. gasseri and positive outcomes in relation to weight loss, fasting blood glucose (FBS)(Reference Million, Angelakis and Paul5), and inflammation(Reference Yun, Park and Kang6). The aim of this study to look at the effect of 4 weeks of supplementation with L. gasseri THT 031301 on obesity, glycaemic, and inflammatory markers.

This is a single centre, double-blind, randomised, placebo-controlled pilot study that recruited fourteen adult subjects with BMI > 25 kg/m2, who were randomly assigned to receive either a supplement containing L. gasseri THT 031301 (n = 6) or a placebo (n = 7). Pregnant and lactating women, subjects on anti-diabetic medications, and subjects who have undergone heart surgery have been excluded. Consented subjects were asked to consume 2 capsules per day continuously for 4 weeks. L. gasseri THT 031301 daily dosage was approximately 6x 109cfu. Alterations in obesity markers were assessed using BMI and waist-to-height ratio (WtHR), and inflammatory markers were measured using enzyme-linked immunosorbent assay (ELISA). FBS level, HBA1c, and insulin measured to indicate the glycaemic markers. Each marker measured at baseline and after 4 weeks.

After 4-weeks supplementation, a significant reduction in waist circumference (WC) (P = 0.022) and (WtHR) (P = 0.035) was identified in the THT 031301 compared to the placebo. Within-group comparisons attributed this finding to a significant increase in WC (93.4 ± 10.1 vs 94.6 ± 9.5, P = 0.040) and WtHR (0.55 ± 0.04 vs 0.56 ± 0.04, P = 0.047) in the placebo group. THT 031301 identified a small increase in the anti-inflammatory cytokine IL-10; however, this was not statistically significant. No changes were identified with the glycaemic markers HbA1c, fasting blood glucose, or insulin.

The current pilot study suggests a potential anti abdominal obesity effect of L. gasseri THT 031301 on the glycaemic markers in healthy adults, but this effect needs to be investigated in a large adequately powered RCT. The study did not find a significant effect of L. gasseri THT 031301 on the glycaemic markers. Future studies might recruit obese and overweight subjects or subjects with diabetes to confirm the anti-obesity, anti-diabetic and anti-inflammatory effect of L. gasseri THT 031301.

Acknowledgements

We would like to thank all the participants for taking part in this trial.

References

Kerry, RG, Patra, JK, Gouda, S, et al. (2018) J Food Drug Anal, 26(3), 927–939.CrossRefGoogle Scholar
Olivares, M, Díaz-Ropero, MP, Gómez, N et al. (2006) Int Microbiol 9(1), 47–52.Google Scholar
Oh, NS, Joung, JY, Lee, JY & Kim, Y. (2018) PloS one 13(2), e0192021.Google Scholar
Kadooka, Y., Sato, M., Imaizumi, K et al. (2010) Eur J Clin. Nutr 64(6), 636–643.CrossRefGoogle Scholar
Million, M, Angelakis, E, Paul, M, et al. (2012) Microb Pathog. 53(2),100–8.CrossRefGoogle Scholar
Yun, SI, Park, HO, Kang, JH (2009) J Appl Microbiol 107(5), 1681–6.CrossRefGoogle Scholar