Hostname: page-component-89b8bd64d-x2lbr Total loading time: 0 Render date: 2026-05-08T10:18:41.099Z Has data issue: false hasContentIssue false
  • English
  • Français

Genomics and proteomics: importance for the future of nutrition research

Published online by Cambridge University Press:  09 March 2007

H. Daniel
H. Daniel*
Affiliation:
Molecular Nutrition Unit, Department of Food and Nutrition, Technical University of Munich, Hochfeldweg 2, D-85350 Freising-Weihenstephan, Germany
*
*Corresponding author: Prof. Dr H. Daniel, tel +49 8161 713 400, fax +49 8161 713 999, email daniel@weihenstephan.de
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the 'Save PDF' action button.

A huge number of genes within the human genome code for proteins that mediate and/or control nutritional processes. Although a large body of information on the number of genes, on chromosomal localisation, gene structure and function has been gathered, we are far from understanding the orchestrated way of how they make metabolism. Nevertheless, based on the genetic information emerging on a daily basis, we are offered fantastic new tools that allow us new insights into the molecular basis of human metabolism under normal as well as pathophysiological conditions. Recent technological advancements have made it possible to analyse simultaneously large sets of mRNA and/or proteins expressed in a biological sample or to define genetic heterogeneity that may be important for the individual response of an organism to changes in its nutritional environment. Applications of the new techniques of genome and proteome analysis are central for the development of nutritional sciences in the next decade and its integration into the rapidly developing era of functional genomics.

Keywords

GenomeProteomeNutrition research

Information

Type
Research Article
Information
British Journal of Nutrition , Volume 87 , Issue S2 , May 2002 , pp. S305 - S311
Copyright
Copyright © The Nutrition Society 2002

References

Adam, GC, Cravatt, BF & Sorensen, EJ (2001) Profiling the specific reactivity of the proteome with non-directed activity-based probes. Chemistry and Biology 8, 81–95.CrossRefGoogle ScholarPubMed
Amundson, SA, Do, KT, Shahab, S, Bittner, M, Meltzer, P, Trent, J & Fornace, AJ Jr (2000) Identification of potential mRNA biomarkers in peripheral blood lymphocytes for human exposure to ionizing radiation. Radiation Research 154, 342–346.CrossRefGoogle ScholarPubMed
Banks, RE, Dunn, MJ, Forbes, MA, Stanley, A, Pappin, D, Naven, T, Gough, M, Harnden, P & Selby, PJ (1999) The potential use of laser capture microdissection to selectively obtain distinct populations of cells for proteomic analysis-preliminary findings. Electrophoresis 20, 689–700.3.0.CO;2-J>CrossRefGoogle ScholarPubMed
Beeley, LJ, Duckworth, DM & Southan, C (2000) The impact of genomics on drug discovery. Progress in Medicinal Chemistry 37, 1–43.CrossRefGoogle ScholarPubMed
Blackstock, WP & Weir, MP (1999) Proteomics: quantitative and physical mapping of cellular proteins. Trends in Biotechnology 17, 121–127.CrossRefGoogle ScholarPubMed
Buetow, KH, Edmonson, M, Mac Donald, R, Clifford, R, Yip, P, Kelley, J, Little, DP, Strausberg, R, Koester, H, Cantor, CR & Braun, A (2001) High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proceedings of the National Academy of Sciences USA 98, 581–584.CrossRefGoogle ScholarPubMed
Celis, JE, Kruhoffer, M, Gromova, I, Frederiksen, C, Ostergaard, M, Thykjaer, T, Gromov, P, Yu, J, Palsdottir, H, Magnusson, N & Orntoft, TF (2000) Gene expression profiling: monitoring transcription and translation products using DNA microarrays and proteomics. FEBS Letters 480, 2–16.CrossRefGoogle ScholarPubMed
Chalmers, MJ & Gaskell, SJ (2000) Advances in mass spectrometry for proteome analysis. Current Opinion in Biotechnology 11, 384–390.CrossRefGoogle ScholarPubMed
Cordwell, SJ, Nouwens, AS, Verrills, NM, Basseal, DJ & Walsh, BJ (2000) Subproteomics based upon protein cellular location and relative solubilities in conjunction with composite two-dimensional electrophoresis gels. Electrophoresis 21, 1094–1103.3.0.CO;2-0>CrossRefGoogle ScholarPubMed
Corthals, GL, Wasinger, VC, Hochstrasser, DF & Sanchez, JC (2000) The dynamic range of protein expression: a challenge for proteomic research. Electrophoresis 21, 1104–1115.3.0.CO;2-C>CrossRefGoogle ScholarPubMed
Dutt, MJ & Lee, KH (2000) Proteomic analysis. Current Opinion in Biotechnology 11, 176–179.CrossRefGoogle ScholarPubMed
Edvardsson, U, Alexandersson, M, Brockenhuus von Lowenhielm, H, Nystrom, AC, Ljung, B, Nilsson, F & Dahllof, B (1999) A proteome analysis of livers from obese (ob/ob) mice treated with the peroxisome proliferator WY14,643. Electrophoresis 20, 935–942.3.0.CO;2-6>CrossRefGoogle ScholarPubMed
Gevaert, K & Vandekerckhove, J (2000) Protein identification methods in proteomics. Electrophoresis 21, 1145–1154.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
Glynne, R, Ghandour, G, Rayner, J, Mack, DH & Goodnow, CC (2000) B-lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays. Immunolical Reviews 176, 216–246.Google ScholarPubMed
Gorg, A, Obermaier, C, Boguth, G, Harder, A, Scheibe, B, Wildgruber, R & Weiss, W (2000) The current state of two-dimensional electrophoresis with immobilized pH gradients. Electrophoresis 21, 1037–1053.3.0.CO;2-V>CrossRefGoogle ScholarPubMed
Haugen, A (1999) Progress and potential of genetic susceptibility to environmental toxicants. Scandinavian Journal of Work Environment and Health 25, 537–540.CrossRefGoogle ScholarPubMed
Lee, CK, Klopp, RG, Weindruch, R & Prolla, TA (1999) Gene expression profile of aging and its retardation by caloric restriction. Science 285, 1390–1393.CrossRefGoogle ScholarPubMed
Lee, CK, Weindruch, R & Prolla, TA (2000) Gene-expression profile of the ageing brain in mice. Nature Genetics 25, 294–297.CrossRefGoogle ScholarPubMed
Lockhart, DJ & Winzeler, EA (2000) Genomics, gene expression and DNA arrays. Nature 405, 827–836.CrossRefGoogle ScholarPubMed
Marrack, P, Mitchell, T, Hildeman, D, Kedl, R, Teague, TK, Bender, J, Rees, W, Schaefer, BC & Kappler, J (2000) Genomic-scale analysis of gene expression in resting and activated T cells. Current Opinion in Immunology 12, 206–209.CrossRefGoogle ScholarPubMed
Norton, RM (2001) Clinical pharmacogenomics: applications in pharmaceutical R&D. Drug Discovery Today 6, 180–185.CrossRefGoogle ScholarPubMed
Pandey, A & Mann, M (2000) Proteomics to study genes and genomes. Nature 405, 837–846.CrossRefGoogle ScholarPubMed
Patton, WF (2000) Making blind robots see: the synergy between fluorescent dyes and imaging devices in automated proteomics. Biotechniques 28, 944–948.CrossRefGoogle ScholarPubMed
Perera, FP & Weinstein, IB (2000) Molecular epidemiology: recent advances and future directions. Carcinogenesis 21, 517–524.CrossRefGoogle ScholarPubMed
Radtkey, R, Feng, L, Muralhidar, M, Duhon, M, Canter, D, Di Pierro, D, Fallon, S, Tu, E, McElfresh, K, Nerenberg, M & Sosnowski, R (2000) Rapid, high fidelity analysis of simple sequence repeats on an electronically active DNA microchip. Nucleic Acids Research 28, E17–E17.CrossRefGoogle Scholar
Rininger, JA, Di Pippo, VA & Gould-Rothberg, BE (2000) Differential gene expression technologies for identifying surrogate markers of drug efficacy and toxicity. Drug Discovery Today 5, 560–568.CrossRefGoogle ScholarPubMed
Ross, P, Hall, L & Haff, LA (2000) Quantitative approach to single-nucleotide polymorphism analysis using MALDI-TOF mass spectrometry. Biotechniques 29, 620–626.CrossRefGoogle ScholarPubMed
Schork, NJ, Fallin, D & Lanchbury, JS (2000) Single nucleotide polymorphisms and the future of genetic epidemiology. Clinical Genetics 58, 250–264.CrossRefGoogle ScholarPubMed
Simone, NL, Paweletz, CP, Charboneau, L, Petricoin, EF & Liotta, LA (2000) Laser capture microdissection: beyond functional genomics to proteomics. Molecular Diagnosis 5, 301–307.CrossRefGoogle ScholarPubMed
Sun, X, Ding, H, Hung, K & Guo, B (2000) A new MALDI-TOF based mini-sequencing assay for genotyping of SNPS. Nucleic Acids Research 28, E68–E68.CrossRefGoogle ScholarPubMed
Tan, KT, Dempsey, A & Liew, CC (1999) Cardiac genes and gene databases for cardiovascular disease genetics. Current Hypertension Report 1, 51–58.CrossRefGoogle ScholarPubMed
Trayhurn, P (2000) Proteomics and nutrition: a science for the first decade of the new millennium. British Journal of Nutrition 83, 1–2.CrossRefGoogle ScholarPubMed
Yates, JR III (2000) Mass spectrometry. From genomics to proteomics. Trends in Genetics 16, 5–8.CrossRefGoogle ScholarPubMed