If X is a compact Hausdorff space and E a dual Banach space, let C(X, Eσ*) denote the Banach space of continuous functions F from X to E when the latter space is provided with its weak * topology, normed by
. It is shown that if X and Y are extremally disconnected compact Hausdorff spaces and E is a uniformly convex Banach space, then the existence of an isometry between C(X, Eσ*) and C(Y, Eσ*) implies that X and Y are homeomorphic.