This article examines the thriving lodging house sector in early modern Venice, arguing that such spaces of temporary accommodation offer a valuable key to understanding how mobility and migration shaped the daily lived experience of the city. Lodging houses were important both to the many Venetian residents who profited from renting out rooms, and to the people who stayed in them, and found there companionship, conversation and access to social and professional networks. Considering the kinds of encounters, conflicts and exchanges that unfolded in these shared spaces, the article offers new insight into the functioning of a pre-modern multicultural metropolis.