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Accepted manuscript

Pharmacological interventions for social cognitive impairments in schizophrenia: A systematic review and network meta-analysis of randomized controlled trials

Published online by Cambridge University Press:  13 February 2026

Yuji Yamada Open the ORCID record for Yuji Yamada [Opens in a new window] ,
Norio Watanabe Open the ORCID record for Norio Watanabe [Opens in a new window] ,
Yui Tomo Open the ORCID record for Yui Tomo [Opens in a new window] ,
Hisateru Tachimori Open the ORCID record for Hisateru Tachimori [Opens in a new window] ,
Toru Horinouchi Open the ORCID record for Toru Horinouchi [Opens in a new window] ,
Takashi Uchino Open the ORCID record for Takashi Uchino [Opens in a new window] ,
Ryotaro Kubota Open the ORCID record for Ryotaro Kubota [Opens in a new window] ,
Hiroki Okano Open the ORCID record for Hiroki Okano [Opens in a new window] ,
Shuhei Ishikawa Open the ORCID record for Shuhei Ishikawa [Opens in a new window]  and
Ryo Sawagashira Open the ORCID record for Ryo Sawagashira [Opens in a new window]
...Show all authors
Yuji Yamada
Affiliation:
Department of Forensic Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Norio Watanabe
Affiliation:
Department of Psychiatry, Soseikai General Hospital, Kyoto, Japan.
Yui Tomo
Affiliation:
Clinical Research & Education Promotion Division, National Center of Neurology and Psychiatry, Tokyo, Japan.
Hisateru Tachimori
Affiliation:
Department of Health Policy and Management, Keio University School of Medicine, Tokyo, Japan. Department of Information Medicine, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
Toru Horinouchi
Affiliation:
Department of Psychiatry, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
Takashi Uchino
Affiliation:
Department of Neuropsychiatry, Toho University Faculty of Medicine, Tokyo, Japan.
Ryotaro Kubota
Affiliation:
Department of Forensic Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Hiroki Okano
Affiliation:
Department of Psychiatry, Fukushima Medical Center of Mental Health, Fukushima, Japan.
Shuhei Ishikawa
Affiliation:
Department of Psychiatry, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
Ryo Sawagashira
Affiliation:
Department of Psychiatry, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
Keisuke Takanobu
Affiliation:
Department of Psychiatry, Hokkaido University Graduate School of Medicine, Hokkaido, Japan. Forensic Psychiatry Center, Hokkaido University Hospital, Hokkaido, Japan.
Yumi Hasegawa
Affiliation:
Department of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Yohei Sasaki
Affiliation:
Clinical Research & Education Promotion Division, National Center of Neurology and Psychiatry, Tokyo, Japan. Faculty of Human Sciences, Musashino University, Tokyo, Japan.
Motohiro Nishiuchi
Affiliation:
Graduate School of Human and Social Sciences, Musashino University, Tokyo, Japan.
Tomiki Sumiyoshi
Affiliation:
Department of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Naoki Hashimoto
Affiliation:
Department of Psychiatry, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
Satoru Ikezawa
Affiliation:
Department of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Takahiro Nemoto
Affiliation:
Department of Neuropsychiatry, Toho University Faculty of Medicine, Tokyo, Japan.
Ryo Okubo*
Affiliation:
Clinical Research & Education Promotion Division, National Center of Neurology and Psychiatry, Tokyo, Japan. Department of Psychiatry, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
*
*Address correspondence and reprint requests to: Ryo Okubo, MD, PhD, Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo, Hokkaido 060-8638, Japan. E-Mail: rokubo0425@gmail.com

Abstract

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Keywords

social cognitionemotion perceptionemotion processingtheory of mindsocial perceptionattributional biasempathy

Information

Type
Review/Meta-analysis
Information
European Psychiatry , Accepted manuscript , pp. 1 - 56
Creative Commons
Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - ND
This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
Copyright
© The Author(s), 2026. Published by Cambridge University Press on behalf of European Psychiatric Association
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