Hostname: page-component-5db58dd55d-jnbmb Total loading time: 0 Render date: 2026-06-01T20:10:58.205Z Has data issue: false hasContentIssue false
  • English
  • Français

Iron free radicals and arthritis

Published online by Cambridge University Press:  28 February 2007

David R. Blake ,
Peter Merry ,
Cliff Stevens ,
Alya Dabbagh ,
Tulin Sahinoglu ,
Ros Allen  and
Chris Morris
David R. Blake
Affiliation:
The London Inflammation Group, The London Hospital Medical College, Whitechapel, London E1 2AD
Peter Merry
Affiliation:
The London Inflammation Group, The London Hospital Medical College, Whitechapel, London E1 2AD
Cliff Stevens
Affiliation:
The London Inflammation Group, The London Hospital Medical College, Whitechapel, London E1 2AD
Alya Dabbagh
Affiliation:
The London Inflammation Group, The London Hospital Medical College, Whitechapel, London E1 2AD
Tulin Sahinoglu
Affiliation:
The London Inflammation Group, The London Hospital Medical College, Whitechapel, London E1 2AD
Ros Allen
Affiliation:
The London Inflammation Group, The London Hospital Medical College, Whitechapel, London E1 2AD
Chris Morris
Affiliation:
The London Inflammation Group, The London Hospital Medical College, Whitechapel, London E1 2AD
Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'

Information

Type
Symposium on ‘Micronutrients and free radicals’
Information
Proceedings of the Nutrition Society , Volume 49 , Issue 2 , July 1990 , pp. 239 - 245
Copyright
Copyright © The Nutrition Society 1990

References

Allen, R. E., Outhwaite, J., Morris, C. J. & Blake, D. R. (1987). Xanthine oxidoreductase is present in human synovium. Annals of the Rheumatic Diseases 46, 843–845.CrossRefGoogle ScholarPubMed
Andrews, F. J., Morris, C. J., Lewis, E. J. & Blake, D. R. (1987). Effect of nutritional iron deficiency on acute and chronic inflammation. Annals of the Rheumatic Diseases 46, 859–865.CrossRefGoogle ScholarPubMed
Aust, S. D. & Svingen, B. A. (1982). The role of iron in enzymatic lipid peroxidation. In Free Radicals in Biology, vol. 5, pp. 1–2 [Pryor, W. A., editor]. New York: Academic Press.Google Scholar
Biemond, P., Swaak, A. J. G., Biendorff, C. M. & Koster, J. F. (1986). Superoxide-dependent and independent mechanisms of iron mobilisation from ferritin by xanthine oxidase. Biochemical Journal 239, 169–173.CrossRefGoogle ScholarPubMed
Blake, D. R. & Bacon, P. A. (1982). Effect of oral iron on rheumatoid patients. Lancet i, 623.CrossRefGoogle Scholar
Blake, D. R., Gallagher, P. J., Potter, A. R., Bell, M. J. & Bacon, P. A. (1984). The effect of synovial iron on the progression of rheumatoid disease. Arthritis and Rheumatism 27, 495–501.CrossRefGoogle ScholarPubMed
Blake, D. R., Lunec, J., Ahern, M., Ring, E. F. J., Bradfield, J. & Gutteridge, J. M. C. (1985). Effect of I. V. Iron dextran on rheumatoid synovitis. Annals of the Rheumatic Diseases 44, 183–188.CrossRefGoogle Scholar
Blake, D. R., Merry, P., Unsworth, J., Kidd, B. L., Outhwaite, J., Ballard, R., Morris, C., Grey, L. & Lunec, L. (1989). Hypoxic-reperfusion injury in the inflamed human joint. Lancet i, 289–293.CrossRefGoogle Scholar
Castor, C. W. (1960). The microscopic structure of normal human synovial tissue. Arthritis and Rheumatism 3, 140–151.CrossRefGoogle ScholarPubMed
Caughy, D. E. & Bywaters, E. G. L. (1963). Joint fluid pressure in chronic knee effusions. Annals of the Rheumatic Diseases 22, 106–109.CrossRefGoogle Scholar
Dabbagh, A. J., Morris, C. J. & Blake, D. R. (1988). Effect of iron complexes on animal models of inflammation. British Journal of Rheumatology 27, 26 Abstr.Google Scholar
Dabbagh, A. J., Morris, C. J. & Blake, D. R. (1989). A hydrogen peroxide initiated model of chronic inflammation. British Journal of Rheumatology 28, 45 Abstr.Google Scholar
Della Corte, E. & Stirpe, F. (1972). The regulation of rat liver xanthine oxidase: involvement of thiol groups in the conversion of the enzyme activity from the dehydrogenase (type D) to the oxidase (type 0) and purification of the enzyme. Biochemical Journal 126, 739–745.CrossRefGoogle Scholar
Falchuk, K. H., Goetzl, E. J. & Kulka, J. P. (1970). Respiratory gases of synovial fluid. An approach to synovial tissue circulatory-metabolic in balance in rheumatoid arthritis. American Journal of Medicine 49, 223–231.CrossRefGoogle Scholar
Geborek, P., Forslind, K. & Wollheim, F. A. (1989). Direct assessment of synovial blood flow and its relation to induced hydrostatic pressure changes. Annals of the Rheumatic Diseases 48, 281–286.CrossRefGoogle ScholarPubMed
Goldie, I. (1970). The synovial microvascular derangement in rheumatoid arthritis and osteoarthritis. Acta Orthopaedica Scandinavica 40, 751–764.CrossRefGoogle Scholar
Halliwell, B. & Gutteridge, J. M. C. (1985). The importance of free radicals and catalytic ions in human disease. Molecular Aspects of Medicine 8, 89–193.CrossRefGoogle Scholar
Halliwell, B. & Gutteridge, J. M. C. (1986). Iron and free radical reactions: two aspects of antioxidant Protection. Trends in Biochemical Sciences 11, 372–375.CrossRefGoogle Scholar
Henderson, B. & Edwards, J. C. W. (1987). In The Synovial Lining in Health and Disease. London: Chapman & Hall.Google Scholar
Jayson, M. I. V. & Dixon, A. StJ. (1970 a). Intra-articular pressure in rheumatoid arthritis of the knee. I. Pressure changes during passive joint distension. Annals of the Rheumatic Diseases 29, 261–265.CrossRefGoogle ScholarPubMed
Jayson, M. I. V. & Dixon, A. StJ. (1970 b). Intra-articular pressure in rheumatoid arthritis of the knee. III. Pressure changes during joint usc. Annals of the Rheumatic Diseases 29, 401.CrossRefGoogle ScholarPubMed
Jennings, R. B. & Reimer, K. A. (1981). Lethal myocardial ischaemic injury. American Journal of Pathology 102, 241–255.Google Scholar
Jennings, R. B., Reimer, K. A., Hill, M. A. & Mayer, S. E. (1981). Total ischaemia in dogs hearts. I. A. comparison of high energy phosphate production, utilisation and depletion and of adenine nucleotoide catabolism in total ischaemia in vitro. Circulation Research 49, 892–900.CrossRefGoogle Scholar
Kelley, M. K. & Amy, N. K. (1984). Effect of molybdenum-deficient and low Fe diets on xanthine oxidase activity and Fe states in rats. Journal of Nutrition 114, 1652–1659.CrossRefGoogle Scholar
Key, J. A. (1929). Experimental arthritis, the reaction of joints to mild irritants. Journal of Bone & Joint Surgery 11, 705–708.Google Scholar
Lunec, J., Blake, D. R., McCleary, S. J., Brailsford, S. & Bacon, P. A. (1985). Self perpetuating mechanisms of immunoglobulin G aggregation in rheumatoid inflammation. Journal of Clinical Investigation 76, 2084–2090.CrossRefGoogle ScholarPubMed
McCarty, D. J. (1979). Synovial fluid. In Arthritis and Allied Conditions, 9th ed. pp. 51–69 [McCarty, D. J., editor]. Philadelphia: Lea & Febiger.Google Scholar
McCord, J. M. (1985). Oxygen derived free radicals in post-ischaemic tissue injury. New England Journal of Medicine 312, 159–163.Google Scholar
Merry, P., Grootveld, M. & Blake, D. R. (1989 a). Hypoxic-Reperfusion injury in inflamed joints. Lancet i, 1023.CrossRefGoogle Scholar
Merry, P., Kidd, B. L., King, J., Stevens, C. R., Mapp, P., King, J. & Blake, D. R. (1989 b). A comparison between intra-articular pressure generation in acute traumatic and chronic inflammatory knee joint effusions. British Journal of Rheumatology 28(2), 23.Google Scholar
Morris, C. J., Balke, D. R., Hewitt, S. D. & Lunec, J. (1987). Macrophage ferritin and iron deposits in the rat air pouch model of inflammatory synovitis. Annals of the Rheumatic Diseases 46, 334–338.CrossRefGoogle ScholarPubMed
Morris, C. J., Blake, D. R., Wainwright, A. C. & Steven, M. M. (1986). Relationship between iron deposits and tissue damage in the synovium: an ultrastructural study. Annals of the Rheumatic Diseases 45, 21–26.CrossRefGoogle ScholarPubMed
Muirden, K. D. & Senator, G. B. (1968). Iron in the synovial membrane in rheumatoid arthritis and other joint diseases. Annals of the Rheumatic Diseases 27, 38–48.CrossRefGoogle ScholarPubMed
Reeves, B. (1966). Negative pressure in knee joints. Nature 212, 1046.CrossRefGoogle Scholar
Roy, R. S. & McCord, J. M. (1983). Superoxide and ischacmia: conversion of xanthine dehydrogenase to xanthine oxidase. In Oxy Radicals and Their Scavenger Systems vol. 2. Cellular and Molecular Aspects, pp. 145–153 [Greenwald, R. and Cohen, G., editors]. New York: Elsevier Science.Google Scholar
Spencer, J. D., Hayes, K. C. & Alexander, I. J. (1984). Knee joint effusions and quadriceps reflex inhibition in man. Archives of Physical Medicine and Rehabilatation 65, 171–177.Google ScholarPubMed
Winyard, P. G., Blake, D. R., Chirico, S., Gutteridge, J. M. C. & Lunec, J. (1987). Mechanism of exacerbation of rheumatoid synovitis by total dose iron dextran infusion: In-vitro demonstration of iron-promoted oxidant stress. Lancet i, 69–72.CrossRefGoogle Scholar
Yoshino, S., Blake, D. R., Hewitt, S., Morris, C. & Bacon, P. A. (1985). Effect of blood on the activity and persistence of Ag-induced inflammation in the rat air pocket. Annals of the Rheumatic Diseases 44, 485–490.CrossRefGoogle Scholar