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The role of dairy products in supplying conjugated linoleic acid to man's diet: a review
Published online by Cambridge University Press: 14 December 2007
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Health benefits for man have been associated with conjugated linoleic acid (CLA) and dairy products are highlighted as offering the best opportunity to increase CLA consumption. CLA is synthesised in the rumen as an intermediate in the biohydrogenation of linoleic acid to stearic acid. The supplies of both intermediates and endproducts of biohydrogenation are affected by the substrate supply and extent of biohydrogenation, thus influencing the CLA content of milk from ruminants. The majority of CLA is present in the rumen in the form of the cis-9,trans-11 isomer. The transfer efficiency of CLA to milk fat is affected by the presence of different isomers of CLA. Ruminant mammary and adipose cells are able to synthesise cis-9,trans-11-CLA from trans-11-18:1 (vaccenic acid) by the action of the Δ9-desaturase enzyme. Plant oils are high in both linoleic and linolenic acids, which results in increased CLA production in the rumen and in the mammary gland. The CLA content of milk increases when cows are offered grazed grass. Many published studies examining the CLA concentration of processed milk were confounded by variations in the concentration of CLA in the raw milk.
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References
Banks, W, Clapperton, JL, Kelly, ME, Wilson, AG & Crawford, RJM (1980) The yield, fatty acid composition and physical properties of milk fat obtained by feeding soya oil to dairy cows. Journal of the Science of Food and Agriculture 31, 368–374.CrossRefGoogle ScholarPubMed
Bartlet, JC & Chapman, DG (1961) Detection of hydrogenated fats in butter fat by measurement of cis-trans conjugated unsaturation. Journal of Agricultural and Food Chemistry 9, 50–53.CrossRefGoogle Scholar
Bauman, DE, Peel, CJ, Steinhour, WD, Reynolds, PJ, Tyrrell, HF, Brown, ACG & Haaland, GL (1988) Effect of bovine somatotropin on metabolism of lactating dairy cows: influence on rates of irreversible loss and oxidation of glucose and nonesterified fatty acids. Journal of Nutrition 118, 1031–1040.CrossRefGoogle ScholarPubMed
Baumgard, LH, Corl, BA, Dwyer, DA, Saebø, A & Bauman, DE (2000) Identification of the conjugated linoleic acid isomer that inhibits milk fat synthesis. American Journal of Physiology 278, 179–184.Google ScholarPubMed
Boylston, TD, Lin, H, Luedecke, LO & Shultz, TD (1996) Effect of processing on the formation of conjugated linoleic acids (CLA) in yoghurt. IFT Annual Meeting Book of Abstracts 1996, 143.Google Scholar
Caric, M & Kalab, M (1987). Processed cheese products. In Cheese: Chemistry, Physics and Microbiology, pp. 339–383 [Fox, PF editor]. London: Elsevier Applied Science.Google Scholar
Chamruspollert, M & Sell, JL (1999) Transfer ofdietary conjugated linoleic acid to egg yolks of chickens. Poultry Science 78, 1138–1150.CrossRefGoogle Scholar
Chilliard, Y (1993) Dietary fat and adipose tissue metabolism in ruminants, pigs and rodents: a review. Journal of Dairy Science 76, 3897–3931.CrossRefGoogle ScholarPubMed
Chilliard, Y & Bocquier, F (1993) Effects of fat supplementation on milk yield and composition in dairy goats and ewes. In La Qualita nelle Produzioni dei Piccoli Ruminanti, Camera di Commercio Industria Artigianato Agricoltura di Varese, Italy (The quality of production of the small ruminant, Chamber of Commerce of commercial industry, handicrafts and agriculture, Varese, Italy), pp. 61–78 [Enne, G and Greppi, GF editors].Google Scholar
Chilliard, Y, Ferlay, A, Mansbridge, RJ & Doreau, M (2000) Ruminant milk fat plasticity: nutritional control of saturated, polyunsaturated, trans and conjugated fatty acids. Annales de Zootechnie 49, 181–205.CrossRefGoogle Scholar
Chin, SF, Liu, W, Storkson, JM, Ha, YL & Pariza, MW (1992) Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognised class of anti-carcinogens. Journal of Food Composition and Analysis 5, 185–197.CrossRefGoogle Scholar
Chin, SF, Storkson, JM, Albright, KJ, Cook, ME & Pariza, MW (1994) Conjugated linoleic acid is a growth factor for rats as shown by enhanced weight gain and improved feed efficiency. Journal of Nutrition 124, 2344–2349.CrossRefGoogle ScholarPubMed
Choi, NJ, Kim, EJ, Maeng, WJ, Neville, MA, Enser, M, Wood, JD & Scollan, ND (1997) Rumen biohydrogenation of fatty acids from different sources of fat. Proceedings of the British Society of Animal Science, p, 19.CrossRefGoogle Scholar
Chouinard, PY, Corneau, L, Bauman, DE, Metzger, LE & Bauman, DE (1999) Conjugated linoleic acids alter milk fatty acid composition and inhibit milk fat secretion in dairy cows. Journal of Nutrition 129, 1579–1584.CrossRefGoogle ScholarPubMed
Chouinard, PY, Girard, V & Brisson, G J (1998) Fatty acid profile and physical properties of milk fat from cows fed calcium salts of fatty acids with varying unsaturation. Journal of Dairy Science 81, 471–481.CrossRefGoogle ScholarPubMed
Corl, BA, Chouinard, PY, Dwyer, DA, Bauman, DE, Griinari, JM & Nurmela, KV (1998) Conjugated linoleic acid in milk fat of dairy cows originates in part by endogenous synthesis from trans-11 octadecenoic acid. Journal of Dairy Science 81, Suppl. 1, 233 Abstr.Google Scholar
Czerkawski, JW, Christie, WW, Breckenridge, G & Hunter, MC (1975) Changes in the rumen metabolism of sheep given increasing amounts of linseed oil in their diet. British Journal of Nutrition 34, 25–44.CrossRefGoogle ScholarPubMed
Davis, CL & Brown, RE (1970) Low-fat milk syndrome. In Digestion and Metabolism in the Ruminant, pp. 545–565 [Phillipson, AT editor]. Newcastle upon Tyne: Oriel Press.Google Scholar
Demeyer, D & Doreau, M (1999) Targets and procedures for altering ruminant meat and milk lipids. Proceedings of the Nutrition Society 58, 593–607.CrossRefGoogle ScholarPubMed
Dhiman, TR, Anand, GR, Satter, LD & Pariza, MW (1999) Conjugated linoleic acid content of milk from cows fed different diets. Journal of Dairy Science 82, 2146–2156.CrossRefGoogle ScholarPubMed
Dhiman, TR, Helmink, ED, McMahon, DJ, Fife, RL & Pariza, MW (1999) Conjugated linoleic acid content of milk and cheese from cows fed extruded oilseeds. Journal of Dairy Science 82, 412–419.CrossRefGoogle ScholarPubMed
Dhiman, TR, Satter, LD, Pariza, MW, Galli, MP & Albright, K (1997) Conjugated linoleic acid (CLA) content of milk from cows offered diets rich in linoleic and linolenic acid. Journal of Dairy Science 80, Suppl. 1, 184.Google Scholar
Doreau, M & Chilliard, Y (1997) Effects of ruminal or post-ruminal fish oil supplementation on intake and digestion in dairy cows. Reproduction Nutrition Développement 37, 113–124.CrossRefGoogle ScholarPubMed
Enser, M, Scollan, ND, Choi, NJ, Kurt, E, Hallett, K & Wood, JD (1999) Effect of dietary lipid on the content of conjugated linoleic acid (CLA) in beef muscle. Animal Science 69, 143–146.CrossRefGoogle Scholar
Fellner, V, Sauer, FD & Kramer, JKG (1995) Steady-state rates of linoleic acid biohydrogenation by ruminal bacteria in continuous culture. Journal of Dairy Science 78, 1815–1823.CrossRefGoogle ScholarPubMed
Fellner, V, Sauer, FD & Kramer, JKG (1997) Effects of Nigericin, Monensin and Tetronasin on biohydrogenation in continuous flow through ruminal fermenters. Journal of Dairy Science 80, 921–932.CrossRefGoogle ScholarPubMed
Franklin, ST, Martin, KR, Baer, RJ, Schingoethe, DJ & Hippen, AR (1999) Dietary marine algae (Schizochytrium sp.) increases concentrations of conjugated linoleic, docosahexaenoic and trans-vaccenic acids in milk of dairy cows. Journal of Nutrition 129, 2048–2054.CrossRefGoogle Scholar
Fritsch, J & Steinhart, H (1998) Analysis, occurrence and physiological properties of trans fatty acids (TFA) with particular emphasis on conjugated linoleic acid isomers (CLA) – a review. Fetts/Lipid 100, 190–210.3.0.CO;2-5>CrossRefGoogle Scholar
Garcia-Lopez, S, Echeverria, E, Tsui, I & Balch, B (1994) Changes in the content of conjugated linoleic acid (CLA) in processed cheese during processing. Food Research International 27, 61–64.CrossRefGoogle Scholar
Garton, GA (1960) Fatty acid composition of the lipids of pasture grasses. Nature 187, 511–512.CrossRefGoogle ScholarPubMed
Gerson, T, Jihn, A & King, ASD (1985) The effects of dietary starch and fibre in the in vitro rates of lipolysis and hydrogenation by sheep rumen digesta. Journal of Agricultural Science, Cambridge 105, 27–35.CrossRefGoogle Scholar
Griinari, JM & Bauman, DE (1999) Biosynthesis of conjugated linoleic acid and its incorporation into meat and milk in ruminants. In Advances in Conjugated Linoleic Acid Research, vol. 1, pp. 180–200 [Yurawecz, MP, Mossoba, MM, Kramer, JKG, Pariza, MW and Nelson, GJ editors]. Champaign, IL: AOCS Press.Google Scholar
Griinari, JM, Chouinard, PY & Bauman, DE (1997) Trans fatty acid hypothesis of milk fat depression raised. Proceedings of the Cornell Nutrition Conference 208–216.Google Scholar
Griinari, JM, Dwyer, DA, McGuire, MA & Bauman, DE (1996) Partially hydrogenated fatty acids and milk fat depression. Journal of Dairy Science 79, 177A.Google Scholar
Griinari, JM, Dwyer, DA, McGuire, MA, Bauman, DE, Palmquist, DL & Nurmela, KVV (1998) Trans-octadecenoic acids and milk fat depression in lactating dairy cows. Journal of Dairy Science 81, 1251–1261.CrossRefGoogle ScholarPubMed
Ha, YL, Grimm, NK & Pariza, MW (1989) Newly recognised anti-carcinogenic fatty acids: identification and quantification in natural and processed cheese. Journal of Agricultural and Food Chemistry 37, 75–81.CrossRefGoogle Scholar
Ha, YL, Storkson, JM & Pariza, MW (1990) Inhibition of benzo (a) pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. Cancer Research 50, 1097–1101.Google Scholar
Harfoot, CG & Hazlewood, GP (1988) Lipid metabolism in the rumen. In The Rumen Microbial Ecosystem, pp. 285–322 [Hobson, PN editor]. Amsterdam: Elsevier Science Publishers B.V.Google Scholar
Harfoot, CG & Hazlewood, GP (1997) Lipid metabolism in the rumen. In The Rumen Microbial Ecosystem, pp. 382–426 [Hobson, PN and Stewart, CS editors]. London: Blackie Academic &Professional.CrossRefGoogle Scholar
Hughes, PE, Hunter, WJ & Tove, SB (1982) Biohydrogenation of unsaturated fatty acids: purification and properties of cis-9,trans-11-octadecadienoic reductase. Journal of Biological Chemistry 257, 3643–3649.CrossRefGoogle Scholar
Ip, C, Banni, S, Angioni, E, Carta, G, McGinley, J, Thompson, HJ, Barbano, D & Bauman, D (1999) Conjugated linoleic acid-enriched butter fat alters mammary gland morphogenesis and reduces cancer risk in rats. Journal of Nutrition 129, 2135–2142.CrossRefGoogle ScholarPubMed
Ip, C, Scimeca, JA & Thomson, HJ (1994) Conjugated linoleic acid: A powerful anti-carcinogen from animal fat sources. Cancer 74, 1050–1054.Google Scholar
Jahreis, G, Fritsche, J, Möckel, P, Schöne, F, Möller, U & Steinhart, H (1999) The potential anticarcinogenic conjugated linoleic acid, cis-9,trans-11 C18:2, in milk of different species: cow, goat, sow, mare, woman. Nutrition Research 19, 1541–1549.CrossRefGoogle Scholar
Jahreis, G, Fritsche, J & Steinhart, H (1996) Monthly variations of milk composition with special regard to fatty acids depending on season and farm management systems conventional versus ecological. Fett Wissenschaft Technologie – Fat Science Technology 98, 356–359.Google Scholar
Jahreis, G, Fritsche, J & Steinhart, H (1997) Conjugated linoleic acid in milk fat: high variation depending on production system. Nutrition Research 17, 1479–1484.CrossRefGoogle Scholar
Jenkins, TC (1993) Lipid metabolism in the rumen. Journal of Dairy Science 76, 3851–3863.CrossRefGoogle ScholarPubMed
Jiang, J, Bjoerck, L, Fonden, R & Emmanuelson, M (1996) Occurrence of conjugated cis-9, trans-11 octadecadienoic acid in bovine milk: effects of feed and dietary regimen. Journal of Dairy Science 79, 438–445.CrossRefGoogle ScholarPubMed
Jiang, J, Wolk, A & Vessby, B (1999) Relation between the intake of milk fat and the occurrence of conjugated linoleic acid in human adipose tissue. American Journal of Clinical Nutrition 70, 21–27.CrossRefGoogle ScholarPubMed
Kalscheur, KF, Teter, BB, Piperova, LS & Erdman, RA (1997) Effect of dietary forage concentration and buffer addition flow of trans C18:1 fatty acids and milk fat production in dairy cows. Journal of Dairy Science 80, 2104–2114.CrossRefGoogle ScholarPubMed
Kanner, J, German, JB & Kinsella, JE (1987) CRC Critical Review Food Science and Nutrition 25, 317–323.CrossRefGoogle Scholar
Kelly, ML, Berry, JR, Dwyer, DA, Griinari, JM, Chouinard, PY, Van Ambugh, DE & Bauman, DE (1998 b) Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy cows. American Society for Nutritional Sciences 128, 881–885.Google ScholarPubMed
Kelly, ML, Kolver, ES, Bauman, DE, Van Amburgh, ME & Muller, LD (1998) Effect of intake of pasture on concentrations of conjugated linoleic acid in milk of lactating cows. Journal of Dairy Science 81, 1630–1636.CrossRefGoogle ScholarPubMed
Kemp, P, Lander, DJ & Gunstone, FD (1984) The hydrogenation of some cis- and trans-octadecenoic acids to stearic acid by a rumen Fusocillus sp. British Journal of Nutrition 52, 165–170.CrossRefGoogle ScholarPubMed
Kepler, CR, Hirons, KP, McNeill, JJ & Tove, SB (1966) Intermediates and products of the biohydrogenation of linoleic acid by Butyrivibrio fibrisolvens. Journal of Chemistry 241, 1350–1354.Google Scholar
Kepler, CR & Tove, SB (1967) Biohydrogenation of unsaturated fatty acids. Journal of Biological Chemistry 242, 5686–5694.CrossRefGoogle ScholarPubMed
Kobayashi, Y, Wakita, M & Hoshino, S (1992) Effects of the ionophore salinomycin on nitrogen and long-chain fatty acids profiles of digesta in the rumen and duodenum of sheep. Animal Feed Science and Technology 36, 67–76.CrossRefGoogle Scholar
Lawless, F, Stanton, C, L'Escop, P, Devery, R, Dillon, P & Murphy, JJ (1999) Influence of breed on bovine milk cis-9, trans-11-conjugated linoleic acid content. Livestock Production Science 62, 43–49.CrossRefGoogle Scholar
Lin, H, Boylston, TD, Chang, MJ, Luedecke, LO & Shultz, TD (1995) Survey of the conjugated linoleic acid contents of dairy products. Journal of Dairy Science 78, 2358–2365.CrossRefGoogle ScholarPubMed
Mansbridge, RJ & Blake, JS (1997) Nutritional factors affecting the fatty acid composition of bovine milk. British Journal of Nutrition 78, Suppl.1, 37–47.CrossRefGoogle ScholarPubMed
Ministry of Agriculture, Fisheries and Food (1995) National Food Survey 1995. Annual Report on Food Expenditure, Consumption and Nutrient Intakes. London: H.M. Stationery Office.Google Scholar
Mir, Z, Goonewardene, LA, Okine, E, Jaegar, S & Scheer, HD (1999) Effect of feeding canola oil on constituents, conjugated linoleic acid (CLA) and long chain fatty acids in goats' milk. Small Ruminant Research 33, 137–143.CrossRefGoogle Scholar
Mir, Z, Paterson, LJ, Mir, PS & Weselake, R (1997) The effect of dietary supplementation with conjugated linoleic acid (CLA) or linoleic acid rich oil on the CLA content of lamb tissue. Canadian Journal of Animal Science 77, 750A.Google Scholar
Moore, WEC, Burmeister, JA, Brooks, CN, Ranney, RR, Hinkelmann, KH, Schieken, RM & Moore, LVH (1993) Investigation of the influences of puberty, genetics, and environment on the composition of subgingival peridontal floras. Infectious Immunology 61, 2891–2898.CrossRefGoogle Scholar
Offer, NW, Marsden, M, Dixon, J, Speake, BK & Thacker, FE (1999) Effect of dietary fat supplements on levels of n3 polyunsaturated fatty acids, trans acids and conjugated linoleic acid in bovine milk. Animal Science 69, 613–625.CrossRefGoogle Scholar
O'Shea, M, Lawless, F, Stanton, C & Devery, R (1998) Conjugated linoleic acid in bovine milk fat: a food-based approach to cancer chemoprevention. Trends in Food Science Technology 9, 192–196.CrossRefGoogle Scholar
Palmquist, DL & Jenkins, TC (1980) Fat in lactation rations: review. Journal of Dairy Science 63, 1–14.CrossRefGoogle ScholarPubMed
Park, Y, Albright, KJ, Liu, W, Storkson, JM, Cook, ME & Pariza, MW (1997) Effect of conjugated linoleic acid on body composition in mice. Lipids 32, 853–858.CrossRefGoogle ScholarPubMed
Park, Y, McGuire, MK, Behr, R, McGuire, MA, Evans, MA & Schultz, TD (1999) High-fat dairy product consumption increases delta 9c, 11t-18 : 2 (rumenic acid) and total lipid concentrations of human milk. Lipids 34, 543–549.CrossRefGoogle ScholarPubMed
Parodi, PW (1999) Conjugated linoleic acid and other anti-carcinogenic agents of bovine milk fat. Journal of Dairy Science 82, 1339–1349.CrossRefGoogle ScholarPubMed
Parodi, PW (1977) Conjugated octadecadienoic acids of Canadian milk fat: Unsaturated fatty acids. Journal of Dairy Science 60, 1550–1553.CrossRefGoogle Scholar
Precht, D (1995) Variation of trans fatty acids in milk fat. Zeitschrift für Ernährungswissenschaft 34, 27–29.CrossRefGoogle Scholar
Precht, D & Molkentin, J (1995) Trans fatty acids: Implications for health, analytical methods, incidence in edible fats and intake. Die Nahrung 516, 343–374.CrossRefGoogle Scholar
Precht, D & Molkentin, J (1997) Effect of feeding on conjugated cis Δ9, trans Δ11-octadecadienoic acid and other isomers of linoleic acid in bovine milk fats. Nahrung 41, 330–335.CrossRefGoogle ScholarPubMed
Riel, RR (1963) Physico-chemical characteristics of Canadian milk fat. Unsaturated fatty acids. Journal of Dairy Science 46, 102–106.CrossRefGoogle Scholar
Santora, JE, Palmquist, DL & Roehrig, KL (2000) Trans-vaccenic acid is desaturated to conjugated linoleic acid in mice. Journal of Nutrition 130, 208–215.CrossRefGoogle ScholarPubMed
Shantha, NC & Decker, EA (1993) Conjugate linoleic acid concentrations in processed cheese containing hydrogen donors, iron and dairy-based additives. Food Chemistry 47, 257–261.CrossRefGoogle Scholar
Shantha, NC, Decker, EA & Ustunol, Z (1992) Conjugated linoleic acid concentration in processed cheese. Journal of American Oil Chemists Society 69, 435–428.CrossRefGoogle Scholar
Shantha, NC, Ram, LN, O'Leary, J, Hicks, CL & Decker, EA (1995) Conjugated linoleic acid concentrations in dairy products as affected by processing and storage. Journal of Food Science 60, 695–697.CrossRefGoogle Scholar
Stanton, C, Lawless, F, Kjellmer, G, Harrington, D, Devery, R, Connolly, JF & Murphy, J (1997) Dietary influences on bovine milk cis-9, trans-11-conjugated linoleic acid content. Journal of Food Science 62, 1083–1086.CrossRefGoogle Scholar
Steinhart, C (1996) Conjugated linoleic acid – the good news about animal fat. Journal of Chemical Education 73, 302–303.CrossRefGoogle Scholar
Tocher, DR, Leaver, MJ & Hodgson, PA (1998) Recent advances in the biochemistry and molecular biology of fatty acyl desaturases. Progressive Lipid Research 37, 73–117.CrossRefGoogle ScholarPubMed
Van Nevel, CJ & Demeyer, DI (1996) Influence of pH on lipolysis and biohydrogenation of soybean oil by rumen contents in vitro. Reproduction Nutrition Development 36, 53–56.CrossRefGoogle ScholarPubMed
Verhulst, A, Semjen, G, Meerts, U, Janssen, G, Parmentier, G, Asselberghs, S, van Hespen, H & Eyssen, H (1985) Biohydrogenation of linoleic acid by Clostridium sporogenes, Clostridium bifermentans, Clostridium sordellii and Bacteroides sp. FEMS Microbiology Ecology 31, 255–259.CrossRefGoogle Scholar
Vivani, R (1970) Metabolism of long-chain fatty acids in the rumen. Advanced Lipid Research 8, 267–346.CrossRefGoogle Scholar
Ward, RJ, Travers, MT, Richards, SE, Vernon, RG, Salter, AM, Buttery, PJ & Barber, MC (1998) Stearoyl-CoA desaturase mRNA is transcribed from a single gene in the ovine genome. International Journal of Biochemistry and Biophysics 1391, 145–156.Google ScholarPubMed
Werner, SA, Luedecke, LO & Shultz, TD (1992) Determination of conjugated linoleic acid content and isomer distribution in three Cheddar-type cheeses: effects of cheese cultures, processing and ageing. Journal of Agricultural and Food Chemistry 40, 1817–1823.CrossRefGoogle Scholar
Wolff, RL (1995) Content and distribution of trans-18:1 acids in ruminant milk and meat fats. Their importance in European diets and their effect on human milk. Journal of American Oil Chemists Society 72, 259–264.CrossRefGoogle Scholar
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