Introduction
Hearing loss is a common ailment that affects all age groups.1 Hearing loss if left uncorrected has a negative impact on health-related quality of life especially with respect to social and emotional aspects of communication.Reference Bainbridge and Wallhagen2,Reference Nachtegaal, Festen and Kramer3 Hearing loss is also linked to cognitive decline and decrease in work productivity. It impairs language development if present in early childhood.Reference Ching, Crowe and Martin4,Reference Lieu, Tye-Murray and Karzon5 The mechanism of loss may be conductive, sensorineural, or mixed. Conductive hearing loss stems mostly from benign processes such as cerumen impaction, otitis media, cholesteatoma, and otosclerosis. Sensorineural hearing loss (SNHL), in contrast, has a broader range of etiologies including neoplasms and viruses. Due to the possibility of these etiologies, clinicians pursue further investigations beyond the acute phase of SNHL, particularly when symptoms are asymmetric.
Investigations for SNHL often culminate in contrast-enhanced magnetic resonance imaging (CEMRI). Studies have suggested MRI as a preferred imaging modality for the investigation of both sudden and asymmetrical SNHL.Reference Lee, Lee and Kim6–Reference Conte, Di Berardino and Sina8 Gadolinium-enhanced MRI of the whole brain including the auditory pathway can give valuable information and can confirm the underlying cause for SNHL.Reference Aarnisalo, Suoranta and Ylikoski9,Reference Schick, Brors and Koch10 CEMRI has been suggested to be the gold standard for the investigation of asymmetrical SNHL with 100% sensitivity and specificity.Reference Cueva11 Unfortunately, MRI cost and access are perennial problems within any healthcare system including that of Canada. The average waiting time for non-urgent MRI studies was 10.6 weeks in 2018.Reference Bacchus, David and Antonia12 The typical cost of such a study is reported to be several thousands of dollars.Reference Jayawardena, Shearer and Smith13 The investigation itself, with the use of gadolinium, is not without risk to the patient.Reference Soares, Lequin and Huisman14 These risks may not outweigh the benefits given that the majority of investigations are negative. Thus, the aforementioned factors suggest that current practice requires further examination to determine whether MRI is being deployed appropriately for SNHL and whether study yield can be increased.
Vestibular schwannomas are a rare cause of asymmetrical SNHL and have an estimated prevalence of 0.1–7.0 per 10,000 people when detected by MRI.Reference Lin, Hegarty and Fischbein15 Although the actual prevalence of this condition is very low in patients with SNHL, visualization of vestibular schwannomas can be facilitated by administration of IV contrast during an MRI examination.Reference Sharma and Kirsch16 According to American College of Radiology Appropriateness Criteria for hearing loss and/or vertigo,Reference Sharma and Kirsch16 there is insufficient evidence to prove incremental benefit of contrast administration beyond an MRI internal auditory canal (IAC) protocol performed without IV contrast in patients presenting with SNHL. In a recent survey,Reference Jiang, Mhoon and Saadia-Redleaf17 approximately 95% of American neurotologists reported that they ordered an MRI in patients with asymmetrical SNHL and sudden deafness, despite the awareness of a high prevalence of negative test results. About 40% of these otologists stated that medicolegal concerns were a significant factor in their decision to pursue imaging.Reference Jiang, Mhoon and Saadia-Redleaf17 Many studiesReference Crowson, Rocke and Hoang18–Reference Sharma, Viets and Parsons21 have suggested a non-contrast MRI with a dedicated IAC protocol to be used as an initial screening test for patients with SNHL. Sequences like T2-weighted imaging and a steady-state free precession (brand names “FIESTA,” “TrueFISP,” and balanced FFE) provide higher spatial resolution and clearer depiction of tiny intracranial structures. These sequences are more cost-effective than CEMRI and provide excellent spatial resolution of the cerebellopontine angle structures including the cisterns, the lower cranial nerves tracts, as well as the composition of the IAC and cochlea.
In recent years with campaigns such as “Choosing Wisely,” there has been a huge shift in the medical community to rethink the inappropriate overuse of medical tests and treatments that provide patients with little added value.Reference Rao and Levin22,Reference Levinson, Kallewaard and Bhatia23 The purpose of our study was to audit the use and diagnostic yield of CEMRI for the clinical indication of SNHL in our institution and to identify characteristics that may be leveraged to improve yield and optimize resource utilization.
Materials and Methods
The study was approved by our Institutional Research Ethics Board (REB #: 1021597). This was a single-center retrospective chart review of consecutive patients who had undergone CEMRI of head with IAC protocol for investigation of asymmetric SNHL between August 2011 and July 2016. Patients were excluded if they (1) were followed for known acoustic neuroma, (2) were being investigated for trigeminal neuralgia or multiple sclerosis, (3) had previously undergone stereotactic therapy or other intervention, (4) had no specified indications on the requisition, and (5) refused contrast or did not receive contrast due to known allergies to gadolinium contrast agent. Additional information was also collected on the clinical presentation, any other neurological deficits, and the specialty of referring physicians or other healthcare professionals. When applicable, we also recorded data on the symptomatic response to a short course of prednisone in treated patients.
Data were compiled and analyzed in Excel (Microsoft, Redmond, WA, USA). Patients were categorized as those with relevant positive findings or those without findings on CEMRI, and different characteristics were compared between them. Chi-squared and two-sample t-test analyses were used to compare proportions and means, respectively, between the two groups. A p-value of <0.05 was considered significant.
Results
A total of 500 consecutive patients were reviewed. Of these, 176 met our exclusion criteria and the remaining 324 patients were included in our final analysis. The demographic details, referral pattern, and clinical characteristics are summarized in Table 1. The mean age of study patients was 56.2 years (range 18–86) and more than half were males (55%). The majority (92%) of referrals for CEMRI came from the otolaryngologists. The most common indication cited for CEMRI was asymmetric SNHL. All patients who had relevant positive findings on CEMRI were referred from otolaryngologists. Twenty out of 301 patients (6.6%) referred from otolaryngologists had relevant positive findings on CEMRI.
Demographics and clinical findings by CEMRI findings (N = 324)
PMR=physical medicine and rehabilitation; ABR=auditory brainstem response; VEMP=vestibular-evoked myogenic potential; CEMRI: contrast-enhanced magnetic resonance imaging.
Of 324 study participants meeting the inclusion criteria, 20 (6.2%) had relevant positive findings on CEMRI (Table 2). Vestibular schwannomas accounted for 19 of the 20 (95%) patients with positive relevant findings. All other findings on CEMRI were irrelevant or negative.
Summary of findings on CEMRI
CEMRI=contrast-enhanced magnetic resonance imaging.
In comparing patients with relevant positive findings on CEMRI to those without, several significant differences were found between the two groups. A greater proportion of participants with relevant positive CEMRI findings (35%) had abnormal auditory brainstem response (ABR)/vestibular-evoked myogenic potential (VEMP) tests than those without (6.3%) (p < 0.001). Vestibular symptoms (p = 0.03) and tinnitus (p = 0.07) were more prominent in those with relevant positive CEMRI findings. Duration of symptoms was longer (3.84 years) in those with relevant positive findings on CEMRI compared to those without (2.48 years) but was not statistically significant (p = 0.20).
Majority (92.8%) of those without relevant positive findings on CEMRI did not have any other tests beyond a standard audiometry compared to 65% of those with relevant positive findings on CEMRI (p < 0.001). Abnormal ABR/VEMP test results were found in 35% of those with relevant positive findings on CEMRI compared to in 6.3% of those without (p ≤ 0.001).
Discussion
This study examined the patterns of referral, presenting symptoms, and imaging results in patients who underwent CEMRI at our institution for asymmetrical SNHL, over the course of 5 years. Relevant positive findings were seen on CEMRI in 6.2% of these patients. Similar studies have been conducted with smaller sample sizes, but none were performed in the context of the Canadian healthcare system.Reference Jeong, Choi and Shin24–Reference Cho, Cheon and Park29 Among the aforementioned studies, relevant intracranial abnormality along the acoustic pathway in patients was reported to range from 3.7%Reference Stokroos, Albers and Krikke28 to 31%.Reference Fitzgerald and Mark27 This warrants an assessment of our selection criteria for CEMRI for SNHL at our institution. Although clinical practice guidelines are available regarding the diagnosis and workup for SNHL,Reference Stachler, Chandrasekhar and Archer30 these guidelines do not specify indications for CEMRI in these patients. Our findings suggested that a request for CEMRI in patients with SNHL is expected to yield relevant positive CEMRI findings when requested by otolaryngologists in patients presenting with vestibular symptoms with abnormal ABR or VEMP.
Tests used prior to MRI referral include pure tone audiometry, ABR, and VEMP.Reference Stachler, Chandrasekhar and Archer30 Pure tone audiometry is a subjective test that relies on the patient’s response to given stimuli across a range of frequencies. It is often the first step of investigation. It tests thresholds and allows distinction between conductive hearing loss and SNHL. ABR is a clinical test for the auditory pathway, including the cochlear nerve, often used to test the entire pathway in patients who may not be able to comply with audiometry. It provides an objective and passive measurement of evoked potential in the brainstem in response to loud clicks. Given the recent improvement in resolution and reduction in cost of MRI, appropriateness of ABR as the primary test used to screen for SNHL is debatable.Reference Fortnum, O’Neill and Taylor31 ABR has a low sensitivity and specificity in the evaluation of patients with an asymmetrical SNHL.Reference Cueva11 VEMP testing detects myogenic potentials in the sternocleidomastoid evoked by monaural clicks. These potentials are believed to originate in the inferior vestibular nerve region and have been demonstrated to be an effective means of testing the vestibular nerve.Reference Murofushi, Matsuzaki and Mizuno32 It provides additional information for the tumor, effected nerve division in the IAC, and hence helps in the pre-surgical planning.Reference Lachowska, Glinka and Niemczyk33
It is important to note that over 90% of our patients did not undergo any testing beyond an audiogram prior to CEMRI referral. The low utilization rate of inexpensive and non-invasive adjunct tests could stem from factors such as lack of familiarity, lack of specialized equipment, or from the perception that these investigations do not impact management. Although these tests are not a diagnostic replacement for MRI in patients with vestibular schwannomas, they serve to provide an additional source of information.
Based on a cost-effectiveness model, some studies suggest a diagnostic algorithm that deploys non-contrast MRI as an initial imaging screen in the investigation is less costly than and likely to be as effective as available contrast MRI.Reference Crowson, Rocke and Hoang18,Reference Sharma, Viets and Parsons21,Reference Daniels, Swallow and Shelton34 Although our study does not provide a definitive solution to our current radiological practice for CEMRI for SNHL at our institution, we highlight the small yield of this test for this indication. A non-contrast MRI with high-resolution imaging of the IAC for this indication is likely a better screening test. Our study may help modify the imaging protocol in other centers where CEMRI is used for screening of SNHL.
Limitations to Study
The current study is limited by the biases associated with studies involving retrospective chart review and by the small number of cases with positive findings. Twenty patients had findings related to the SNHL. The small number limits the ability to develop a decision tree, and only simple exploratory statistics were performed. However, this low diagnostic yield with current practices highlighted the reasoning behind this study and brings to focus the potential areas to improve upon.
Conclusion
CEMRI is a valuable tool for assessing potential causes of SNHL, but small diagnostic yield at present needs justification for contrast injection for this indication. Our findings suggest preferred referral from otolaryngologists exclusively, and implementation of a non-contrast MRI for SNHL may be a better diagnostic tool.
Conflict of Interest
The authors declare that they have no conflicts of interest.
Informed Consent
Informed consent was obtained from all individual participants included in the study.
Statement of Authorship
HW – data acquisition and manuscript preparation; YAT – design of study, data acquisition, and final approval; KF – draft and revise the manuscript and final approval; JJSS – conceptualized the project, supervision, design of study, data analysis and interpretation, revision of manuscript, and final approval.
Ethical Approval
All procedures performed were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
