Hostname: page-component-6766d58669-bp2c4 Total loading time: 0 Render date: 2026-05-18T12:28:23.476Z Has data issue: false hasContentIssue false
  • English
  • Français

Selenium and the Immune Response

Published online by Cambridge University Press:  28 February 2007

R. J. Turner  and
Julie M. Finch
R. J. Turner
Affiliation:
Department of Biological Sciences, University College of Wales, Aberystwyth SY23 3DA
Julie M. Finch
Affiliation:
AFRC Institute for Animal Health, Compton, Newbury RG16 0NN
Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'

Information

Type
Symposium on ‘Micronutrients and the immune response’
Information
Proceedings of the Nutrition Society , Volume 50 , Issue 2 , August 1991 , pp. 275 - 285
Copyright
The Nutrition Society

References

Arvilommi, H., Poikonen, K., Jokinen, I., Muukkonen, O., Rasanen, L., Foreman, J. & Huttunen, J. K. (1983). Selenium and immune functions in humans. Infection and Immunity 41, 185–189.CrossRefGoogle ScholarPubMed
Aziz, E. S. & Klesius, P. H. (1985). The effect of selenium deficiency in goats on lymphocyte production of leukocyte migration inhibitory factor. Veterinary Immunology and Immunopathology 10, 381–390.CrossRefGoogle ScholarPubMed
Aziz, E. S., Klesius, P. H. & Frandsen, J. C. (1984). Effects of selenium on polymorphonuclear leukocyte function in goats. American Journal of Veterinary Research 45, 1715–1718.Google ScholarPubMed
Behne, D. & Höfer-Bosse, T. (1984). Effects of a low selenium status on the distribution and retention of selenium in the rat. Journal of Nutrition 114, 1289–1296.CrossRefGoogle ScholarPubMed
Behne, D. & Wolters, W. (1983). Distribution of selenium and glutathione peroxidase in the rat. Journal of Nutrition 113, 456–461.CrossRefGoogle ScholarPubMed
Beilstein, M. A. & Whanger, P. D. (1983). Distribution of selenium and glutathione peroxidase in blood fractions from humans, rhesus and squirrel monkeys, rats and sheep. Journal of Nutrition 113, 2138–2146.CrossRefGoogle ScholarPubMed
Blodgett, D. J., Schurig, G. G., Kornegay, E. T., Meldrum, J. B. & Bonnette, E. D. (1989). Failure of an enhanced dietary selenium concentration to stimulate humoral immunity in gestating swine. Nutrition Reports International 40, 543–550.Google Scholar
Boyne, R. & Arthur, J. R. (1986). The response of selenium-deficient mice to Candida albicans infection. Journal of Nutrition 116, 816–822.CrossRefGoogle ScholarPubMed
Boyne, R., Arthur, J. R. & Wilson, A. B. (1986). An in vivo and in vitro study of selenium deficiency and infection in rats. Journal of Comparative Pathology 96, 379–386.CrossRefGoogle Scholar
Boyne, R., Mann, S. O. & Arthur, J. R. (1984). Effect of Salmonella typhimurium infection on selenium deficient rats. Microbios Letters 27, 83–87.Google Scholar
Burk, R. F. (1989). Newer roles of selenium in nutrition. Journal of Nutrition 119, 1051–1054.CrossRefGoogle ScholarPubMed
DeWitt, W. B. (1957). Experimental schistosomiasis mansoni in mice maintained on nutritionally deficient diets. 2. Survival and development of Schistosoma mansoni in mice maintained on Torula yeast diet deficient in Factor 3, vitamin E, and cystine. Journal of Parasitology 43, 129–135.CrossRefGoogle ScholarPubMed
Dimitrov, N. V., Meyer, C., Ullrey, D. E., Ku, P. K., Primack, S. & Miller, E. R. (1984). Selenium as a metabolic modulator of phagocytosis. In Selenium in Biology and Medicine, pp. 254–262 [Spallholz, J. E., Martin, J. L. and Ganther, H. E., editors]. New York: Avi Publishing Co.Google Scholar
Eskew, M. L., Scholz, R. W., Reddy, C. C., Todhunter, D. A. & Zarkower, A. (1985). Effects of vitamin E and selenium deficiencies on rat immune function. Immunology 54, 173–180.Google ScholarPubMed
Eskew, M. L., Zarkower, A., Scheuchenzuber, W. J., Burgess, J. R., Scholz, R. W., Hildenbrandt, G. & Reddy, C. C. (1989). Effects of inadequate vitamin E and/or selenium nutrition on the release of arachidonic acid metabolites in rat alveolar macrophages. Prostaglandins 38, 79–89.CrossRefGoogle ScholarPubMed
Finch, J. M. & Turner, R. J. (1986). Selenium supplementation in lambs: effects on antibody responses to a Salmonella vaccine. Veterinary Record 119, 430–431.CrossRefGoogle ScholarPubMed
Finch, J. M. & Turner, R. J. (1989). Enhancement of ovine lymphocyte responses: a comparison of selenium and vitamin E supplementation. Veterinary Immunology and Immunopathology 23, 245–256.CrossRefGoogle ScholarPubMed
Flodin, N. W. (1988). Pharmacology of Micronutrients. Current Topic. In Nutrition and Disease, vol. 20, pp. 269–284. New York: A. R. Liss Inc.Google Scholar
Gissel-Nielsen, G., Gupta, U. C., Lamand, M. & Westermarck, T. (1984). Selenium in soils and plants and its importance in livestock and human nutrition. Advances in Agronomy 37, 397–460.CrossRefGoogle Scholar
Hill, J., Allison, F. & Halpin, C. (1985). An episode of acute selenium toxicity in a commercial piggery. Australian Veterinary Journal 62, 207–209.CrossRefGoogle Scholar
Hopper, S. A., Greig, A. & McMurray, C. H. (1985). Selenium poisoning in lambs. Veterinary Record 116, 569–571.CrossRefGoogle ScholarPubMed
Kay, H. D., Petrie, H. T. & Klassen, L. W. (1986). In vitro effects of selenium and T-cell growth factor (TCGF) on natural killer (NK) cell function of lymphocytes from human peripheral blood. IRCS Medical Science 14, 691–692.Google Scholar
Khalil, A. M. (1989). The induction of chromosome aberrations in human purified peripheral blood lymphocytes following in vitro exposure to selenium. Mutation Research 224, 503–506.CrossRefGoogle ScholarPubMed
Kiremidjian-Schumacher, L., Roy, M., Wishe, H. I., Cohen, M. W. & Stotzky, G. (1990). Selenium and immune cell functions. 1. Effect on lymphocyte proliferation and production of interleukin 1 and interleukin 2. Proceedings of the Society for Experimental Biology and Medicine 193, 136–142.CrossRefGoogle ScholarPubMed
Kiremidjian-Schumacher, L. & Stotzky, G. (1987). Selenium and immune responses. Environmental Research 42, 277–303.CrossRefGoogle ScholarPubMed
Koller, L. D., Exon, J. H., Talcott, P. A., Osborne, C. A. & Henningsen, G. M. (1986). Immune responses in rats supplemented with selenium. Clinical and Experimental Immunology 63, 570–576.Google ScholarPubMed
Larsen, H. J., Moksnes, K. & Overnes, G. (1988 a). Influence of selenium on antibody production in sheep. Research in Veterinary Science 45, 4–10.CrossRefGoogle ScholarPubMed
Larsen, H. J., Overnes, G. & Moksnes, K. (1988 b). Effect of selenium on sheep lymphocyte responses to mitogens. Research in Veterinary Science 45, 11–15.CrossRefGoogle ScholarPubMed
Larsen, H. J. & Tollersrud, S. (1981). Effect of dietary vitamin E and selenium on the phytohaemagglutinin response of pig lymphocytes. Research in Veterinary Science 31, 301–305.CrossRefGoogle ScholarPubMed
Marsh, J. A., Combs, G. F., Whitacre, M. E. & Dietert, R. R. (1986). Effect of selenium and vitamin E dietary deficiencies on chick lymphoid organ development. Proceedings of the Society for Experimental Biology and Medicine 182, 425–436.CrossRefGoogle ScholarPubMed
Marsh, J. A., Dietert, R. R. & Combs, G. F. (1981). Influence of dietary selenium and vitamin E on the humoral immunity of the chick. Proceedings of the Society for Experimental Biology and Medicine 166, 228–236.CrossRefGoogle Scholar
Marsh, J. A., Dietert, R. R. & Combs, G. F. (1987). Effect of dietary selenium and vitamin E deficiencies in the chicken on Con A-induced splenocyte proliferation. Progress in Clinical and Biological Research 238, 333–345.Google ScholarPubMed
Meeker, H. C., Eskew, M. L., Scheuchenzuber, W., Scholz, R. W. & Zarkower, A. (1985). Anti oxidant effects on cell-mediated immunity. Journal of Leukocyte Biology 38, 451–458.CrossRefGoogle ScholarPubMed
Moore, S. B. (1989). Selenium in agricultural drainage: essential nutrient or toxic threat? Journal of lrrigation and Drainage Engineering 115, 21–28.Google Scholar
Mulhern, S. A., Taylor, G. L., Magruder, L. E. & Vessey, A. R. (1985). Deficient levels of dietary selenium suppress the antibody response in first and second generation mice. Nutrition Research 5, 201–210.CrossRefGoogle Scholar
Murray, J. M. & Murray, A. B. (1985). The effects of selenium deficiency and repletion on host resistance to infection. In Trace Element. In Man and Animals. TEMA-5, pp. 244–247. Cambridge: Commonwealth Agricultural Bureau.Google Scholar
Nève, J. (1989). Biological functions of selenium. In Selenium in Medicine and Biology, pp. 97–111 [Nève, J. and Favier, A., editors]. New York: Walter de Gruyter.Google Scholar
Parnham, M. J., Winkelmann, J. & Leyck, S. (1983). Macrophage, lymphocyte and chronic inflammatory responses in selenium deficient rodents. Association with decreased glutathione peroxidase activity. International Journal of Immunopharmacology 5, 455–461.CrossRefGoogle ScholarPubMed
Paynter, D. I. (1979). Glutathione peroxidase and selenium in sheep. 1. Effect of intraruminal selenium pellets on tissue glutathione peroxidase activities. Australian Journal of Agricultural Research 30, 695–702.CrossRefGoogle Scholar
Petrie, H. T., Klassen, L. W. & Kay, H. D. (1989). Selenium and the immune response. 1. Modulation of alloreactive human lymphocyte functions in vitro. Journal of Leukocyte Biology 45, 207–214.CrossRefGoogle ScholarPubMed
Phillippo, M., Arthur, J. R., Price, J. & Halliday, G. J. (1987). The effects of selenium, housing and management on the incidence of pneumonia in housed calves. Veterinary Record 121, 509–512.CrossRefGoogle ScholarPubMed
Rosenfeld, I. & Beath, O. A. (1964). Selenium: Geobotany, Biochemistry, Toxicity and Nutrition. New York: Academic Press.Google Scholar
Rotruck, J. T., Pope, A. L., Ganther, H. E., Swanson, A. B., Hafeman, D. G. & Hoekstra, W. G. (1973). Selenium: biochemical role as a component of glutathione peroxidase. Science 179, 588–590.CrossRefGoogle ScholarPubMed
Roy, M., Kiremidjian-Schumacher, L., Wishe, H. I., Cohen, M. W. & Stotzky, G. (1990). Selenium and immune cell functions. 2. Effect on lymphocyte-mediated cytotoxicity. Proceedings of the Society for Experimental Biology and Medicine 193, 143–148.CrossRefGoogle ScholarPubMed
Schwarz, K. & Foltz, C. M. (1957). Selenium as an integral part of Factor 3 against dietary necrotic liver degeneration. Journal of American Chemical Society 79, 3292–3293.CrossRefGoogle Scholar
Segerson, E. C. & Spears, J. W. (1985). Selenium status and phytohaemagglutinin-stimulated T lymphocytes from beef calves. Biological Trace Element Research 8, 173–180.CrossRefGoogle Scholar
Sheffy, B. E. & Schultz, R. D. (1978). Nutrition and the immune response. Cornell Veterinarian 68, Suppl. 7, 48–61.Google Scholar
Spallholz, J. E. (1981 a). Anti-inflammatory, immunologic and carcinostatic attributes of selenium in experimental animals. In Diet and Resistance to Disease. Advances in Experimental Medicine and Biology, vol. 135, pp. 43–62 [Phillips, M. and Baetz, A., editors]. New York: Plenum.CrossRefGoogle Scholar
Spallholz, J. E. (1981 b). Selenium. What role in immunity and immune cytotoxicity? In Selenium in Biology and Medicine, pp. 103–117 [Spallholz, J. E., Martin, J. L. and Ganther, H. E., editors]. Connecticut: Avi Publishing Co.Google Scholar
Suttle, N. F. & Jones, D. G. (1989). Trace elements, disease resistance and immune responsiveness in ruminants. Journal of Nutrition 119, 1055–1061.CrossRefGoogle ScholarPubMed
Szewczuk, M. R., Campbell, R. J. & Jung, L. K. (1981). Lack of age-associated immune dysfunction in mucosa-associated lymph nodes. Journal of Immunology 126, 2200–2204.CrossRefGoogle Scholar
Turner, R. J. & Finch, J. M. (1990). Immunological malfunctions associated with low selenium–vitamin E diets in lambs. Journal of Comparative Pathology 102, 99–109.CrossRefGoogle ScholarPubMed
Turner, R. J., Wheatley, L. E. & Beck, N. F. G. (1985). Stimulatory effects of selenium on mitogen responses in lambs. Veterinary Immunology and Immunopathology 8, 119–124.CrossRefGoogle ScholarPubMed
Urban, T. & Jarstrand, C. (1986). Selenium effects on human neutrophilic granulocyte function in vitro. Immunopharmacology 12, 167–172.CrossRefGoogle ScholarPubMed
Van Vleet, J. F. & Watson, R. R. (1984). Effects of selenium and vitamin E on resistance to infectious disease. In Nutrition, Disease Resistance and Immune Function. Clinical and Experimental Nutrition, vol. 1, pp. 299–312 [Watson, R. R., editor]. New York: Marcel Dekker.Google Scholar
Whanger, P. D., Weswig, P. H. & Oldfield, J. E. (1978). Selenium, sulfur and nitrogen levels in ovine rumen microorganisms. Journal of Animal Science 46, 515–519.CrossRefGoogle ScholarPubMed