Genetic insights into the relationship between age at menarche and mental health-related phenotypes

Yang Chen; Zhi Li; Siwei Huang; Xinrui Li; Wen Jiao; Wangyang Gu; Peng Xue; Hao Mei; Shijian Liu

doi:10.1192/j.eurpsy.2026.12214

Accepted manuscript

Genetic insights into the relationship between age at menarche and mental health-related phenotypes

Published online by Cambridge University Press: 11 May 2026

Zhi Li ,

and

Yang Chen: Affiliation:
Clinical Research Unit, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Clinical Epidemiology and Biostatistics, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Zhi Li: Affiliation:
Clinical Research Unit, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Siwei Huang: Affiliation:
Clinical Research Unit, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Xinrui Li: Affiliation:
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Wen Jiao: Affiliation:
Clinical Research Unit, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Wangyang Gu: Affiliation:
School of Public Health, Hainan Medical University, Haikou, China
Peng Xue: Affiliation:
Health Systems and Equity, Eastern Health Clinical School, Monash University, Australia
Hao Mei: Affiliation:
Department of Data Science, University of Mississippi Medical Center, Jackson, USA
Shijian Liu*: Affiliation:
Clinical Research Unit, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Clinical Epidemiology and Biostatistics, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
*: Correspondence and reprint requests to: Shijian Liu, PhD, Clinical Research Unit, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 274 Zhijiang Middle Rd, Jing’an District, Shanghai, 200040, China, E-mail: shijianliu@shsmu.edu.cn.

Article contents

Abstract

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Abstract

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Keywords

Age at menarche Mental health Genetic correlation Mendelian randomization

Information

Type: Research Article
Information: European Psychiatry , Accepted manuscript , pp. 1 - 30

DOI: https://doi.org/10.1192/j.eurpsy.2026.12214 [Opens in a new window]
Creative Commons: This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.