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  3. Apoptosis in Health and Disease
  • Cited by 7
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    • Publisher:
      Cambridge University Press
      Publication date:
      03 March 2010
      17 February 2005
      ISBN:
      9780511663543
      9780521529563
      9780521159449
      DOI:
      https://doi.org/10.1017/CBO9780511663543
      Dimensions:
      (247 x 174 mm)
      Weight & Pages:
      0.675kg, 260 Pages
      Dimensions:
      (244 x 170 mm)
      Weight & Pages:
      0.43kg, 264 Pages
      • Subjects:
      Life Sciences, Pathology and Laboratory Science, Medicine, Molecular Biology, Biochemistry, and Structural Biology
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    Subjects:
    Life Sciences, Pathology and Laboratory Science, Medicine, Molecular Biology, Biochemistry, and Structural Biology
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    Book description

    The process of programmed cell death or apoptosis has, in the decade preceding the publication of this 2005 book, been shown to be centrally involved in the pathogenesis of the significant majority of human illnesses and injury states. The cellular attrition observed in most degenerative conditions is apoptotic in nature; conversely a failure of apoptosis has been proposed to underlie many forms of cancer. The central role of apoptosis in human disease clearly brings with it clinical promise; for example, the strong possibility exists that attenuation of apoptotic death will significantly modulate the severity of degenerative disorders. Similarly, conditions, such as cancer, autoimmune disease, psoriasis and endometriosis, in which aberrant cellular proliferation is observed, may benefit from enhanced rates of apoptosis. This book surveys the underlying molecular mechanisms of apoptosis, investigates its role in degenerative and other diseases, and evaluates potential therapies that will permit appropriate activation or inhibition of apoptosis in disease and injury states.

    Reviews

    Review of the hardback:‘This book provides a convenient mix of introductory material on apoptosis, with a rapid specialisation and thorough treatment of particular areas. … The introductory material is well written, and gives a comprehensive account of the burgeoning of this field.‘

    David R. Bell - University of Nottingham

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