Peptic ulcers can be developed inside the inner lining of the stomach (gastric ulcers) or the small intestine (duodenal ulcer)^{(Reference Rashid and Soomro1)}. Sesamum indicum seeds is a great source of protein as each 100 grams of seeds contain approximately 19 grams of protein ^{(Reference Rashid and Soomro1)}. Previous research has suggested that sesamum indicum oil can improve peptic ulcers ^{(Reference Rashid and Soomro1,Reference Hanci, Odabasoglu and Dumlu2)} . However, there has been little research done on the effects of sesamum indicum oil on peptic ulcers, and findings remain inconsistent^{(Reference Hanci, Odabasoglu and Dumlu2)}. Therefore, the current study aimed to examine the effects of two different types of sesamum indicum oil (different in colours) available in Saudi local markets.

In total, 60 male albino Sprague Dawley rats weighing approximately 210 ± 15 grams were included. They were divided into four groups (15 in each): group 1: negative control, group 2: ulcer-induced rats (uir), group 3: uir + 1 mg/kg of type 1 sesamum indicum oil, and group 4: uir + 1 mg/kg of type 2 sesamum indicum oil. Gastric ulceration was induced with a single oral dose of indomethacin (30 mg/kg body weight) after a 24 hour food fast . The stomachs were washed, and the ulcer areas were identified on millimeter paper^{(Reference Halici and Kufrevioglu3)}. Then, the ulcer index was calculated as follows: Ulcer index = Ulcer size X ulcer number. The mucin content, volume of the gastric juice, and pH of the gastric juice were determined based on previous method.^{(Reference Sori, Balaji and Adiga4).} Data were analyzed using IBM SPSS, (IBM Corp., Armonk, N.Y., USA). One-way analysis of variance (ANOVA) was used to compare the differences between groups.

Groups 3 showed a significant reduction (p < 0.05) in the ulcer size (3.4 ± 0.4), ulcer number (3.7 ± 0.55), ulcer index (12.58 ± 0.95), and volume of gastric juice (3.17 ± 0.08) compare to group 2 (24.7 ± 0.39), (13.5 ± 0.66), (333.45 ± 17.4), (8.25 ± 0.13) for ulcer size, ulcer number, ulcer index and volume of gastric juice respectively. Groups 4 showed a significant reduction (p < 0.05) in the ulcer size (4.2 ± 0.5), ulcer number (2.5 ± 0.48), ulcer index (10.5 ± 0.76), and volume of gastric juice (4.11 ± 0.23) compare to group 2. In addition, the pH of the gastric juice and Mucin were significantly higher (p < 0.05) in group 3 (4.76 ± 0.05, 339.4 ± 2.2) and in group 4 (4.11 ± 0.11, 344.3 ± 3.1) than group 2 (2.57 ± 0.04, 221.8 ± 1.8) . However, there were no significant differences between both types of sesamum indicum oil based on the mentioned parameters.

In conclusion, consuming both types of sesamum indicum oil can accelerate gastric healing in rats with Indomethacin induced ulcers, and sesamum indicum oil can be consider a potential protective natural agent against gastric ulcer complications. However, no clear inference can be drawn at this stage, so we offer this work for further extensive research.