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Travelling waves with continuous profile for hyperbolic Keller-Segel equation

Published online by Cambridge University Press:  18 September 2024

Quentin Griette*
Affiliation:
Université Le Havre Normandie, Normandie Univ., LMAH UR 3821, Le Havre, France
Pierre Magal
Affiliation:
Univ. Bordeaux, IMB, UMR 5251, F-33400 Talence, France CNRS, IMB, UMR 5251, F-33400 Talence, France
Min Zhao
Affiliation:
Tianjin Chengjian University, School of Science, Tianjin, China
*
Corresponding author: Quentin Griette; Email: quentin.griette@univ-lehavre.fr
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Abstract

This work describes a hyperbolic model for cell-cell repulsion with population dynamics. We consider the pressure produced by a population of cells to describe their motion. We assume that cells try to avoid crowded areas and prefer locally empty spaces far away from the carrying capacity. Here, our main goal is to prove the existence of travelling waves with continuous profiles. This article complements our previous results about sharp travelling waves. We conclude the paper with numerical simulations of the PDE problem, illustrating such a result. An application to wound healing also illustrates the importance of travelling waves with a continuous and discontinuous profile.

Information

Type
Papers
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Author(s), 2024. Published by Cambridge University Press
Figure 0

Figure 1. An illustration of two types of travelling wave solutions.

Figure 1

Figure 2. In this figure, we plot the travelling wave profile $x \to U(x)$.

Figure 2

Figure 3. On the left-hand side, we plot $x \to u_0(x)$ the initial distribution of system (A.1), obtained by using formula (5.1) with $\beta =1$ and $K=20$. On the right-hand side, we plot the travelling wave profile which coincides with $x \to u(t,x)$ the solution of system (A.1) at $t=20$ days.

Figure 3

Figure 4. In this figure, we plot the solution of the model (A.1) starting from the initial distribution (5.1) (with $\beta =1$ and $K=20$).

Figure 4

Figure 5. On the left-hand side, we plot $x \to u_0(x)$ the initial distribution of system (A.1), obtained by using formula (5.2) with $\beta =0.1$ and $K=20$. On the right-hand side, we plot the travelling wave profile which coincide with $x \to u(t,x)$ the solution of system (A.1) at $t=20$ days.

Figure 5

Figure 6. In this figure, we plot the solution of the model (A.1) starting from the initial distribution (5.2) (with $\beta =0.1$ and $K=20$).

Figure 6

Figure 7. Images from a scratch assay experiment at different time points. Human umbilical vein endothelial cells were plated on gelatin-coated plastic dishes, wounded with a p20 pipette tip, and then imaged overnight using a microscope equipped with point visiting and live-cell apparatus. Scale bar = 120 $\mu$m. This figure is taken from Jonkman et al. [14].

Figure 7

Figure 8. On the left-hand side, we plot $x \to u_0(x)$ the initial distribution of system (A.1), obtained by using formula (6.1) with $\beta =0.5$ and $K=20$. On the right-hand side, we plot $x \to u(t,x)$ the solution of system (A.1) at $t=7$ days.

Figure 8

Figure 9. In this figure, we plot the solution of the model (A.1) starting from the initial distribution (6.1) (with $\beta =0.5$ and $K=20$).

Figure 9

Figure 10. On the left-hand side, we plot $x \to u_0(x)$ the initial distribution of system (A.1), obtained by using formula (6.2) with $\beta =0.07$ and $K=20$. On the right-hand side, we plot $x \to u(t,x)$ the solution of system (A.1) at $t=7$ days.

Figure 10

Figure 11. In this figure, we plot the solution of the model (A.1) starting from the initial distribution (6.2) (with $\beta =0.07$ and $K=20$).