Hematological Complications in Obstetrics, Pregnancy, and Gynecology

doi:10.1017/CBO9780511526978

There are many haematological complications associated with obstetrics, pregnancy and gynaecology, and unfortunately, they often lead to significant morbidity or mortality for both mother and child. As the first comprehensive reference on all aspects of haematological complications of obstetrics, pregnancy and gynaecology this book will be a valuable resource to haematologists, obstetricians, gynaecologists, reproductive medicine specialists, internists, anaesthesiologists and others. The chapters are written by acknowledged experts in the field, and for each condition covered the etiology, pathophysiology, clinical and laboratory diagnosis and management are discussed where appropriate.

"Many of the chapters, such as those on thrombophilia, [DVT/PE], and [LMWH] in pregnancy are excellent, up-to-date and highly recommended reading for obstetrical anesthesiologists."
Roanne Preston MD FRCPC, Canadian Anesthesia

"This textbook is an excellent guide for all of those involved in obstetrics, gynecology perinatology and even neonatology. It is highly recommended for all practicing and resident physicians in these areas."
Julian L Ambrus, MD. PhD. FACP; Clara M. Ambrus, MD, PhD, FACP, The Journal of Medicine

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Contents

Frontmatter
pp i-vi
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Contents
pp vii-viii
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List of contributors
pp ix-x
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Preface
pp xi-xii
- By Rodger L. Bick, Clinical Professor of Medicine and Pathology, University of Texas, Southwestern Medical Center, Dallas Texas, USA, Eugene Frenkel, Professor of Medicine Harold C. Simmons Comprehensive Cancer Center, Dallas Texas, USA, William Baker, Professor of Medicine Thrombosis Center, Bakersfield, California, USA, Ravindra Sarode, University of Texas, Southwestern Medical Center, Dallas Texas, USA
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1 - Disseminated intravascular coagulation in obstetrics, pregnancy, and gynecology: Criteria for diagnosis and management
pp 1-54
- By Rodger L. Bick, M.D., Ph.D., F.A.C.P., Clinical Professor of Medicine and Pathology, University of Texas Southwestern Medical Center, Director: Dallas Thrombosis Hemostasis and Vascular Medicine Clinical Center, Dallas, Texas, USA, Deborah Hoppensteadt, Ph.D., D.I.C., Associate Professor of Pathology, Loyola University Medical Center, Maywood, Illinois, USA
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2 - Recurrent miscarriage syndrome and infertility caused by blood coagulation protein/platelet defects
pp 55-74
- By Rodger L. Bick, M.D., Ph.D., F.A.C.P., Clinical Professor of Medicine and Pathology, University of Texas Southwestern Medical Center; Director: Dallas Thrombosis Hemostasis and Vascular Medicine Clinical Center, Dallas, Texas, USA
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3 - Von Willebrand disease and other bleeding disorders in obstetrics
pp 75-102
- By Franklin Fuda, D.O., Fellow: Hematopathology Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA, Ravindra Sarode, M.D., Professor of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
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4 - Hemolytic disease of the fetus and newborn caused by ABO, Rhesus, and other blood group alloantibodies
pp 103-121
- By Katharine A. Downes, M.D., Assistant Professor Department of Pathology, University Hospitals of Cleveland, Cleveland, Ohio, USA, Ravindra Sarode, M.D., Professor of Pathology, University of Texas Southwestern Medical Center Director: Transfusion Medicine and Hemostasis, Dallas, Texas, USA
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5 - Hereditary and acquired thrombophilia in pregnancy
pp 122-199
- By Rodger L. Bick, M.D., Ph.D., F.A.C.P., Professor of Medicine and Pathology, University of Texas Southwestern Medical Center; Director: Dallas Thrombosis Clinical Center, Dallas, Texas; Director: Pacific Thrombosis Clinical Center, Southern California, USA, William F. Baker, Jr., M.D., F.A.C.P., Associate Clinical Professor of Medicine, Center for Health Sciences, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA, USA, Thrombosis, Hemostasis, and Special Hematology Clinic, Kern Medical Center, Bakersfield; California Clinical Thrombosis Center, Bakersfield, California, USA
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6 - Thromboprophylaxis and treatment of thrombosis in pregnancy
pp 200-221
- By L. Heilmann, Professor of Obstetrics and Gynaecology, City Hospital, Rüsselsheim, W. Rath, Professor of Obstetrics and Gynaecology, University of Aachen, Aachen, Germany, R. L. Bick, Clinical Professor of Medicine and Pathology, University of Texas Southwestern Medical Center; Director: Dallas
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7 - Diagnosis of deep vein thrombosis and pulmonary embolism in pregnancy
pp 222-249
- By William F. Baker, Jr., M.D., F.A.C.P.,, Associate Clinical Professor of Medicine Center for Health Sciences, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA, USA Thrombosis, Hemostasis, and Special Hematology Clinic, Kern Medical Center, Bakersfield, Eugene P. Frenkel, M.D., F.A.C.P.,, Professor of Medicine and Radiology Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical School, Dallas, Texas, USA, Rodger L. Bick, M.D., Ph.D., F.A.C.P., Clinical Professor of Medicine and Pathology, University of Texas Southwestern Medical Medical Center, Director: Dallas Thrombosis Hemostasis and Vascular Medicine Clinical Center, Dallas, Texas, USA
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8 - Hemorrhagic and thrombotic lesions of the placenta
pp 250-268
- By Raymond W. Redline, M.D, Professor of Pathology and Reproductive Biology, Case School of Medicine; Co-Director, Pediatric and Perinatal Pathology, University Hospitals of Cleveland, Cleveland Ohio, USA
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9 - Iron deficiency, folate, and vitamin B12 deficiency in pregnancy, obstetrics, and gynecology
pp 269-309
- By William F. Baker, Jr., M.D., F.A.C.P., Associate Clinical Professor of Medicine Center for Health Sciences, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA, USA Thrombosis, Hemostasis and Special Hematology Clinic, Kern Medical Center, Bakersfield, California, USA, Ray Lee, M.D., Associate Professor of Internal Medicine, University of Texas Southwestern School of Medicine, Dallas, Texas, USA
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10 - Thrombosis prophylaxis and risk factors for thrombosis in gynecologic oncology
pp 310-340
- By Georg-Friedrich von Tempelhoff, M.D., F.A.C.T.H., Specialist in Gynecology and Obstetrics, Department of Obstetrics and Gynecology GP Rüsselsheim, Teaching Hospital of the Johannes Gutenberg-University Main 2, Rüsselsheim, Germany
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11 - Low molecular weight heparins in pregnancy
pp 341-360
- By Debra A. Hoppensteadt, Ph.D., Professor of Pathology and Pharmacology, Loyola University, Chicago Maywood, Illinois, USA, Jawed Fareed, Ph.D., Professor of Pathology and Pharmacology, Loyola University, Chicago, Maywood, Illinois, USA, Harry L. Messmore, M.D., Professor Emeritus Department of Medicine, Loyola University, Chicago, Maywood, Illinois, USA, Omer Iqbal, M.D., Research Assistant Professor Department of Pathology, Loyola University, Chicago, Maywood, Illinois, USA, William Wehrmacher, M.D., Professor Emeritus Department of Physiology, Loyola Univeristy, Chicago, Maywood, Illinois, USA, Rodger L. Bick, M.D., Ph.D., Clinical Professor of Medicine and Pathology, University of Texas Southwestern Medical Center
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12 - Post partum hemorrhage: Prevention, diagnosis, and management
pp 361-441
- By William F. Baker, Jr., M.D., F.A.C.P., Associate Clinical Professor of Medicine Center for Health Sciences, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA, USA, Thrombosis, Hemostasis and Special Hematology, Clinic, Kern Medical Center, Bakersfield, California, Joseph Mansour, M.D., Associate Professor Department of Obstetrics and Gynecology, Kern Medical Center, Bakersfield, California, USA, Arthur Fontaine, M.D., Chairman of Radiology, Mercy Hospital, Bakersfield, California, USA
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13 - Hemoglobinopathies in pregnancy
pp 442-468
- By Adeboye H. Adewoye, M.D., Assistant Professor of Medicine, Martin H. Steinberg, M.D., Professor of Medicine Pediatrics, Pathology and Laboratory Medicine
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14 - Genetic counseling and prenatal diagnosis
pp 469-489
- By Karen Heller, M.S., C.G.C., Faculty Associate Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Texas, USA, Robyn Horsager, M.D., Associate Professor Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, Texas, USA
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15 - Thrombocytopenia in pregnancy
pp 490-505
- By Ravindra Sarode, M.D., Professor of Pathology, University of Texas Southwestern Medical Center at Dallas, Texas, USA, Eugene P. Frenkel, M.D., Professor of Medicine and Radiology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical School, Dallas, Texas, USA
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16 - Neonatal immune thrombocytopenias
pp 506-527
- By Katharine A. Downes, M.D., Assistant Professor Department of Pathology, University Hospitals of Cleveland, Cleveland, Ohio, USA, Ravindra S. Sarode, M.D., Professor of Pathology, University of Texas Southwestern Medical Center; Director: Transfusion Medicine and Hemostasis, Dallas, Texas, USA
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17 - The rational use of blood and its components in obstetrical and gynecological bleeding complications
pp 528-555
- By Katharine A. Downes, M.D., Assistant Professor Department of Pathology, University Hospitals of Cleveland, Cleveland, Ohio, USA, Ravindra Sarode, M.D., Professor of Pathology, University of Texas Southwestern Medical Center; Director: Tran sfusio n Medicine and Hemostasis, Dallas, Texas, USA
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18 - Heparin-induced thrombocytopenia in pregnancy
pp 556-569
- By Barbara B. Haley, M.D., Professor of Medicine Sherry Wigley Crow Cancer Research Endowed Chair in Honour of Robert Lewis Kirby, M.D. University of Southwestern Medical School, Dallas, Texas, USA, Rodger L. Bick, M.D., Ph.D., Clinical Professor of Medicine and Pathology, University of Taxas, Southwestern Medical Center, Eugene P. Frenkel, M.D., Professor of Medicine and Radiology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical School, Dallas, Texas, SA
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19 - Coagulation defects as a cause for menstrual disorders
pp 570-588
- By Albert J. Phillips, M.D., F.A.C.O.G., Clinical Professor of Obstetrics and Gynecology, University of Southern California, School of Medicine, 1301 20th Street, Suite 270, Santa Monica, California 90404, USA
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Index
pp 589-604
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Plate section
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Hematological Complications in Obstetrics, Pregnancy, and Gynecology

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Contents

Frontmatter
pp i-vi

Contents
pp vii-viii

List of contributors
pp ix-x

Preface
pp xi-xii

1 - Disseminated intravascular coagulation in obstetrics, pregnancy, and gynecology: Criteria for diagnosis and management
pp 1-54

2 - Recurrent miscarriage syndrome and infertility caused by blood coagulation protein/platelet defects
pp 55-74

3 - Von Willebrand disease and other bleeding disorders in obstetrics
pp 75-102

4 - Hemolytic disease of the fetus and newborn caused by ABO, Rhesus, and other blood group alloantibodies
pp 103-121

5 - Hereditary and acquired thrombophilia in pregnancy
pp 122-199

6 - Thromboprophylaxis and treatment of thrombosis in pregnancy
pp 200-221

7 - Diagnosis of deep vein thrombosis and pulmonary embolism in pregnancy
pp 222-249

8 - Hemorrhagic and thrombotic lesions of the placenta
pp 250-268

9 - Iron deficiency, folate, and vitamin B12 deficiency in pregnancy, obstetrics, and gynecology
pp 269-309

10 - Thrombosis prophylaxis and risk factors for thrombosis in gynecologic oncology
pp 310-340

11 - Low molecular weight heparins in pregnancy
pp 341-360

12 - Post partum hemorrhage: Prevention, diagnosis, and management
pp 361-441

13 - Hemoglobinopathies in pregnancy
pp 442-468

14 - Genetic counseling and prenatal diagnosis
pp 469-489

15 - Thrombocytopenia in pregnancy
pp 490-505

16 - Neonatal immune thrombocytopenias
pp 506-527

17 - The rational use of blood and its components in obstetrical and gynecological bleeding complications
pp 528-555

18 - Heparin-induced thrombocytopenia in pregnancy
pp 556-569

19 - Coagulation defects as a cause for menstrual disorders
pp 570-588

Index
pp 589-604

Plate section

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Hematological Complications in Obstetrics, Pregnancy, and Gynecology

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