The Neurobiology of Disease: Contributions from Neuroscience to Clinical Neurology

doi:10.1017/CBO9780511570193

This volume demonstrates the value of interactions between neurology and the basic sciences that underpin it. The text considers a range of topics from the points of view of both neurobiologist and clinician and reveals how advances in our understanding are made. The selected topics cover a wide range of levels of organization in the nervous system. For each one, distinguished researchers from around the world make contributions, including general reviews of normal and pathological mechanisms as well as detailed accounts of the basic processes involved. The book's coverage boasts an excellent section on the physiology and pathophysiology of central and peripheral nerve fibres. Also of particular note are the chapters on neuronal plasticity, cell death and axonal regeneration. The book is dedicated to Tom Sears, who at the time of its original publication was retiring as Professor at London's Institute of Neurology (Queen Square).

"...a valuable read as it projects an immediate overview and understanding of key membrane and molecular events involved in axonal conductions and mechanisms of neural control and neural viability in health and disease." Roger N. Rosenberg, Archives of Neurology

"...this is a well-written, adequately illustrated, and generally interesting textbook that will be found a useful resource for neuroscientists of all different specialties." Martin Bettag, Neurosurgery Review

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Contents

Frontmatter
pp i-viii
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Contents
pp ix-xi
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List of contributors
pp xii-xvi
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Preface
pp xvii-xx
- By Hugh Bostock, Institute of Neurology, London, P. A. Kirkwood, Institute of Neurology, London, A. H. Pullen, Institute of Neurology, London
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Part I - Physiology and pathophysiology of nerve fibres
pp 1-2
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1 - Ion channels in normal and pathophysiological mammalian peripheral myelinated nerve
pp 3-12
- By J. M. Ritchie, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA
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2 - Molecular anatomy of the node of Ranvier: newer concepts
pp 13-28
- By S. G. Waxman, Department of Neurology, Yale University School of Medicine, New Haven, and Center for Neuroscience Research, VA Hospital, West Haven, Connecticut, USA
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3 - Delayed rectifier type potassium currents in rabbit and rat axons and rabbit Schwann cells
pp 29-36
- By M. D. Baker, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA
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4 - Axonal signals for potassium channel expression in Schwann cells
pp 37-46
- By T. Konishi, Department of Neurology, Utano National Hospital, Kyoto, Japan
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5 - Ion channels in human axons
pp 47-60
- By G. Reid, Sobell Department of Neurophysiology, Institute of Neurology, London, UK.
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6 - An in vitro model of diabetic neuropathy: electrophysiological studies
pp 61-68
- By P. Grafe, Department of Physiology, University of Munich, Munich, Germany
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7 - Autoimmunity at the neuromuscular junction
pp 69-74
- By J. Newsom-Davis, Neurosciences Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
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8 - Immunopathology and pathophysiology of experimental autoimmune encephalomyelitis
pp 75-85
- By M. P. Pender, Department of Medicine, The University of Queensland, Brisbane, Queensland, Australia
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9 - Pathophysiology of human demyelinating neuropathies
pp 86-94
- By T. E. Feasby, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
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10 - Conduction properties of central demyelinated axons: the generation of symptoms in demyelinating disease
pp 95-117
- By K. J. Smith, Department of Neurology and Division of Anatomy and Cell Biology, United Medical and Dental Schools of Guy's and St Thomas' Hospitals, London, UK
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11 - Mechanisms of relapse and remission in multiple sclerosis
pp 118-123
- By W. I. McDonald, Department of Clinical Neurology, Institute of Neurology, London, UK
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12 - Glial transplantation in the treatment of myelin loss or deficiency
pp 124-148
- By J. Rosenbluth, Department of Physiology and Neuroscience and Rusk Institute of Rehabilitation Medicine, New York University School of Medicine, New York, USA
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Part II - Pain
pp 149-150
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13 - Human nociceptors in health and disease
pp 151-161
- By J. Ochoa, Good Samaritan Hospital and Medical Center, Oregon Health Sciences University, Portland, Oregon, USA.
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14 - Sensory consequences of inflammation
pp 162-168
- By A. Iggo, Department of Preclinical Veterinary Sciences, University of Edinburgh, Scotland, UK
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15 - Non-voluntary muscle activity and myofascial pain syndromes
pp 169-176
- By R. H. Westgaard, Division of Organization and Work Science, University of Trondheim, Trondheint, Norway
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16 - Is there a mechanism for the spinal cord to remember pain?
pp 177-188
- By W. D. Willis, Jr, Department of Anatomy & Neurosciences and Marine Biomedical Institute, University of Texas Medical Branch, Galveston, Texas, USA
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17 - The neurophysiological basis of pain relief by acupuncture
pp 189-198
- By E. Shen, Shanghai Brain Research Institute, Shanghai, China.
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Part III - Control of central nervous system output
pp 199-200
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18 - Synaptic transduction in neocortical neurones
pp 201-209
- By W. E. Crill
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19 - Cortical circuits, synchronization and seizures
pp 210-220
- By J. G. R. Jefferys, Department of Physiology and Biophysics, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, UK
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20 - Physiologically induced changes of brain temperature and their effect on extracellular field potentials
pp 221-230
- By P. Andersen, Department of Neurophysiology, Institute of Basic Medical Sciences, University of Oslo, Norway, E. Moser, Department of Neurophysiology, Institute of Basic Medical Sciences, University of Oslo, Norway, V. Jensen, Department of Neurophysiology, Institute of Basic Medical Sciences, University of Oslo, Norway
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21 - Fusimotor control of the respiratory muscles
pp 231-240
- By A. Taylor, Sherrington School of Physiology, United Medical and Dental Schools, St Thomas' Hospital Campus, London, UK, R. Durbaba, Sherrington School of Physiology, United Medical and Dental Schools, St Thomas' Hospital Campus, London, UK
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22 - Cerebral accompaniments and functional significance of the long-latency stretch reflexes in human forearm muscles
pp 241-246
- By M. J. Aminoff, Department of Neurology, University of California, San Francisco, California, USA, D. S. Goodin, Department of Neurology, University of California, San Francisco, California, USA
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23 - The cerebellum and proprioceptive control of movement
pp 247-256
- By A. Prochazka, Division of Neuroscience, University of Alberta, Edmonton, Alberta, Canada., M. Gorassini, Division of Neuroscience, University of Alberta, Edmonton, Alberta, Canada., J. Taylor, Division of Neuroscience, University of Alberta, Edmonton, Alberta, Canada.
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The Neurobiology of Disease

Contributions from Neuroscience to Clinical Neurology

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