Management of Hematologic Malignancies

doi:10.1017/CBO9780511781926

Hematologic malignancies were the first human cancers to be studied in depth at the molecular level, and recent years have seen important advances in treatment. This comprehensive reference book covers the full range of hematologic malignancies, including all subtypes of leukemias, lymphomas, and plasma cell dyscrasias. Authored by internationally known experts, each chapter emphasizes diagnostic work-up, staging, and therapeutic approaches. Up-to-date hematopathology, treatment, and outcomes data are presented in a way which is directly applicable to patient care. Highly illustrated with color images, graphs, flowcharts and treatment algorithms, the book is perfect for quick clinical reference as well as providing detailed reference lists for further study. With its authoritative and practical focus and visually stimulating presentation, this is a key text for hematology and oncology fellows, physicians, oncology nurses, physician assistants and other healthcare workers in the field of oncology.

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Contents

Frontmatter
pp i-iv
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Contents
pp v-v
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List of contributors
pp vi-viii
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1 - Molecular pathology of leukemia
pp 1-25
- By Maher Albitar, Hematopathology and Oncology Department, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, USA, Amber Donahue, Hematopathology and Oncology Department, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, USA
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2 - Management of acute myeloid leukemia
pp 26-42
- By Alan K. Burnett, Department of Haematology, University of Wales College of Medicine, Cardiff, UK
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3 - Treatment of acute lymphoblastic leukemia (ALL) in adults
pp 43-67
- By Ryan Mattison, Division of Hematology/Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA, Sarah Larson, Section of Hematology-Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA, Wendy Stock, Section of Hematology-Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA
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4 - Chronic myeloid leukemia
pp 68-80
- By Elias Jabbour, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Hagop M. Kantarjian, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Jorge E. Cortés, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
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5 - Chronic lymphocytic leukemia/small lymphocytic lymphoma
pp 81-102
- By Karen W. L. Yee, Department of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, ON, Canada, Susan M. O'Brien, Hematopathology and Oncology Department, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, USA
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6 - Myelodysplastic syndromes (MDS)
pp 103-115
- By Stefan H. Faderl, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Guillermo Garcia-Manero, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Hagop M. Kantarjian, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
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7 - Hairy cell leukemia
pp 116-130
- By Darren S. Sigal, Division of Hematology/Oncology, Scripps Clinic, La Jolla, CA, USA, Alan Saven, Division of Hematology/Oncology, and Ida M. and Cecil H. Green Cancer Center, Scripps Clinic, La Jolla, CA, USA
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8 - Acute promyelocytic leukemia: pathophysiology and clinical results update
pp 131-140
- By Francesco Lo-Coco, Department of Biopathology, University Tor Vergata, Rome, Italy, Massimo Breccia, Department of Biotechnologies and Cellular Hematology, Sapienza University, Rome, Italy, Syed Khizer Hasan, Department of Biopathology, University Tor Vergata, Rome, Italy
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9 - Myeloproliferative neoplasms
pp 141-154
- By Ayalew Tefferi, Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA
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10 - Monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and multiple myeloma
pp 155-183
- By S. Vincent Rajkumar, Mayo Clinic College of Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, USA, Suzanne R. Hayman, Mayo Clinic College of Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, USA
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11 - Amyloidosis and other rare plasma cell dyscrasias
pp 184-206
- By Angela Dispenzieri, Mayo Clinic College of Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, USA, Suzanne R. Hayman, Mayo Clinic College of Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, USA
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12 - Waldenstrom's macroglobulinemia/lymphoplasmacytic lymphoma
pp 207-227
- By Steven P. Treon, Bing Center for Waldenstrom's Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, Giampaolo Merlini, Department of Biochemistry at the University of Pavia and Biotechnology Research Laboratories, University Hospital Policlinico San Matteo, Pavia, Italy
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13 - WHO classification of lymphomas
pp 228-256
- By William W. L. Choi, Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong, Wing C. Chan, Center for Lymphoma and Leukemia Research, Department of Pathology, Nebraska Medical Center, Omaha, NE, USA
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14 - Molecular pathology of lymphoma
pp 257-276
- By David J. Good, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, BC, Canada, Randy D. Gascoyne, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, BC, Canada
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15 - International staging and response criteria for lymphomas
pp 277-285
- By Bruce D. Cheson, Georgetown University Hospital, Lombardi Comprehensive Cancer Center, Washington DC, USA
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16 - Treatment approach to diffuse large B-cell lymphomas
pp 286-307
- By Sonali M. Smith, The University of Chicago, Chicago, IL, USA, Julie M. Vose, Section of Hematology/Oncology, Nebraska Medical Center, Omaha, NE, USA
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17 - Mantle cell lymphoma
pp 308-337
- By Andre Goy, The John Theurer Cancer Center, Hackensack University Medical Center, NJ, USA
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18 - Follicular lymphomas
pp 338-366
- By Francisco J. Hernandez-Ilizaliturri, Departments of Medicine and Immunology, Roswell Park Institute, Buffalo, NY, USA, Myron S. Czuczman, Departments of Medicine and Immunology, Roswell Park Institute, Buffalo, NY, USA
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19 - Hodgkin lymphoma: epidemiology, diagnosis, and treatment
pp 367-403
- By Andrew M. Evens, Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA, Sandra J. Horning, Stanford University School of Medicine, Stanford, CA, USA
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20 - Treatment approaches to MALT/marginal zone lymphoma
pp 404-409
- By Stephanie A. Gregory, Department of Hematology, Rush University Medical Center, Chicago, IL, USA, Parameswaran Venugopal, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA
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21 - Peripheral T-cell lymphomas
pp 410-431
- By Matthew J. Matasar, Department of Medicine, Lymphoma Service and Hematology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA, Steven M. Horwitz, Department of Medicine, Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
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22 - Mycosis fungoides and Sézary syndrome
pp 432-448
- By Christiane Querfeld, Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL, USA, Steven T. Rosen, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
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23 - Central nervous system lymphoma
pp 449-461
- By Elizabeth R. Gerstner, The Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital Cancer Center, Boston, MA, USA, Tracy T. Batchelor, The Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital Cancer Center, Boston, MA, USA
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24 - HIV-related lymphomas
pp 462-486
- By Caroline M. Behler, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, 111H1, San Francisco, CA, USA, Lawrence D. Kaplan, Division of Hematology/Oncology, University of California San Francisco, CA, USA
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25 - Lymphoblastic lymphoma
pp 487-493
- By Anuj Mahindra, Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA, John W. Sweetenham, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA
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26 - Burkitt lymphoma
pp 494-502
- By Julie M. Vose, Section of Hematology/Oncology, Nebraska Medical Center, Omaha, NE, USA
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Index
pp 503-517
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Management of Hematologic Malignancies

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