Once context–mechanism–outcome configurations (CMOCs) have been refined through qualitative research, they can be tested using quantitative data. A variety of different analyses can be used to assess the validity of CMOCs. Overall, analyses will not assess CMOCs but are nonetheless still useful in determining overall effects. Mediation analyses assess whether any intervention effect on an outcome is explained by intervention effects on intermediate outcomes, and so can shed light on mechanisms. Moderation analyses see how intervention effects vary between subgroups defined in terms of baseline context (settings or populations) and so shed light on contextual differences. Moderated mediation analyses assess whether mediation is apparent in some context but not others, and so can shed light on which mechanisms appear to generate outcomes in which contexts. Qualitative comparative analyses can examine whether more complex combinations of markers of context and mechanism co-occur with markers of outcome. Together, this set of analyses can provide nuanced and rigorous information on which CMOCs appear most usefully to explain how intervention mechanisms interact with context to generate outcomes.