This chapter explores desertion, disaffection, and disloyalty in the South Carolina interior. A spate of unauthorized absence from some military units and frustrations with the war at home led to a problem with disaffection and desertion emerging in the hilly and mountainous fringe along the state’s border with North Carolina during the summer and early fall of 1863. Concerned by this development, the authorities dispatched anti-deserter expeditions to the affected region. Though disturbances caused by recalcitrant deserters in and around the Blue Ridge Mountains would never be fully eradicated, these expeditions were generally effective at restoring order. This outcome warrants emphasis for it is revealing. Similar efforts elsewhere in the Civil War South tended to produce limited results at best or cycles of retaliatory violence at worst, but the relative success of these expeditions suggests that the dispatched troops needed only to reassert Confederate authority, not impose it by force on communities that were either completely out of heart with the war or never bought into the Confederate nation in the first place. This chapter also considers the small, isolated, though quite often impactful networks of dissent that could be found in some parts of the state.