Chapter 4 looks at the strengthening of Indigenous networks in the sertão in the Lower Amazon, especially around the Tapajós and Trombetas rivers. Here missions acted as gateways to the deep multi-ethnic forest networks in Amerindian territories where more slaves and converts could be found, and where people were recruited to work on canoes to collect cacao and the drugs of the hinterlands. In these regions, long standing networks between Indigenous societies had alternated between alliance and peace and war and enslavement. Colonial agents were added as new players in the complex set of relations that linked Belém and the sertão. Sometimes the shift of relations led to the strengthening of Amerindian networks, such as in the south bank areas. The reconfiguring of networks led to the reconstitution of the riverbanks and the creation of the hinterland; each region was different according to local dynamics that spawned singular cultural and social situations.