Hypoxic Encephalopathy in the Neurocritical Care Unit

doi:10.1017/9781107587908.031

Chapter 31 - Hypoxic Encephalopathy in the Neurocritical Care Unit

Published online by Cambridge University Press: 24 July 2019

Maximilian Mulder and

Romergryko G. Geocadin

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Michel T. Torbey

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Michel T. Torbey: Affiliation:
Ohio State University

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Summary

The term hypoxic encephalopathy (HE) refers to a syndrome of global brain injury resulting from critical reduction or loss of blood flow and supply of oxygen and nutrients to the brain. Synonyms used to describe this clinical entity include hypoxic-ischemic or anoxic encephalopathy and postcardiac-arrest brain injury, among others. Most cases of HE can be attributed to complications during the perinatal period in children, and in adults HE mostly results from cardiac arrest or asphyxia, with approximately half a million cases per year of HE in the United States [1]. Hypoxic encephalopathy is one of the most important and devastating clinical manifestations of the postcardiac-arrest syndrome (PCAS) characterized mainly by postcardiac-arrest brain injury, myocardial dysfunction, and a systemic ischemia-reperfusion response [2]. This chapter will cover the initial postresuscitation care, therapeutic hypothermia, and critical care management, as well as prognostication of neurologic outcomes of hypoxic encephalopathy in adults.

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Type: Chapter
Information: Neurocritical Care , pp. 382 - 391

DOI: https://doi.org/10.1017/9781107587908.031 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2019

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