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Chapter 3 - Neutrophil and Platelet Disorders

from Section I - Peripheral Blood

Published online by Cambridge University Press:  25 November 2023

Silvia Tse Bunting
Affiliation:
Cleveland Clinic Florida Weston
Xiayuan Liang
Affiliation:
University of Colorado
Michele E. Paessler
Affiliation:
University of Pennsylvania School of Medicine
Satheesh Chonat
Affiliation:
Emory University, Atlanta
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Summary

Neutrophils are known as the first responders at the sites of infection and injury, but their role in thrombosis is also being recognized. Platelets are known to be an important component in maintaining hemostasis and controlling the bleeding at the site of trauma, as well as in immune modulation [1]. Although some conditions are classified as neutrophilic disorders, they also show clinical manifestations associated with platelet dysfunction, or vice versa. For example, Chediak-Higachi disease is commonly known as neutrophil function disorder; however, it has bleeding history due to abnormal lysosome-like structures inside platelets. Similarly, MYH9-related disorders and Hemansky-Pudlak syndrome are associated with macrothrombocytopenia and storage pool defect but also characterized by neutropenia with recurrent infection and impaired cytotoxic activity.

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