Material culture profoundly influences the ways we understand, experience and represent sexuality. This chapter examines cross-cultural material cultures of heterosexuality, homosexuality, domestic life, communal rituals, sex work and intimate relationships, among other examples. The history of sexuality and material culture is a long one, and to consider Roman brothels, Palauan men’s houses and Peruvian pottery is to recognise their significance in changing sexual mores. Objects, including buildings and artworks, can tell us about fundamentally diverse ways of understanding sexuality as an everyday practice and the subject of academic inquiry. The chapter also offers a discussion of the ephemera of movements for sexual rights in more recent times. These objects may be everyday items repurposed for queer life and politics, for example, or custom-made props for protest and organising. Museums have often paid little attention to the material culture of sexuality, hiding away incriminating exhibits, but new museological approaches to objects reveal the intricacies of intimate life, tell the story of previously marginalized forms of sexuality, and even resist established modes of power. Material culture, and the ways we address it, speak forcefully to the politics of sexuality.