In this chapter, clinical practice is addressed from three perspectives. First, what does good clinical practice in suicide prevention look like? Secondly, there are key matters pertaining to how we both maintain patient safety and avoid iatrogenic harm. These include: an excessive focus on risk; the way in which people can and do fall through gaps between services; the continued use of, contrary to evidence, guidance and humane clinical practice, of behavioural management approaches to self-harm and suicidality, and the risks to patients and service users of ‘group think’ and malignant alienation in clinical cultures. Finally, we will consider what needs to be done to maintain positive standards and values in clinical settings.