Molecular Machines in Biology: Workshop of the Cell

doi:10.1017/CBO9781139003704

The concept of molecular machines in biology has transformed the medical field in a profound way. Many essential processes that occur in the cell, including transcription, translation, protein folding and protein degradation, are all carried out by molecular machines. This volume focuses on important molecular machines whose architecture is known and whose functional principles have been established by tools of biophysical imaging (X-ray crystallography and cryo-electron microscopy) and fluorescence probing (single-molecule FRET). This edited volume includes contributions from prominent scientists and researchers who understand and have explored the structure and functions of these machines. This book is essential for students and professionals in the medical field who want to learn more about molecular machines.

'… insightful language about molecular machines …'

Source: Evolution News and Views

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Contents

Frontmatter
pp i-iv
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Contents
pp v-vi
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Contributors
pp vii-viii
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Figures and Tables
pp ix-xii
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Preface
pp xiii-xiv
- By Joachim Frank
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Introduction
pp 1-3
- By Joachim Frank
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Chapter 1 - Single-Molecule FRET: Technique and Applications to the Studies of Molecular Machines
pp 4-19
- By Xinghua Shi, Taekjip Ha
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Chapter 2 - Visualization of Molecular Machines by Cryo-Electron Microscopy
pp 20-37
- By Joachim Frank
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Chapter 3 - Statistical Mechanical Treatment of Molecular Machines
pp 38-58
- By Debashish Chowdhury
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Chapter 4 - Exploring the Functional Landscape of Biomolecular Machines via Elastic Network Normal Mode Analysis
pp 59-77
- By Karunesh Arora, Charles L Brooks III
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Chapter 5 - Structure, Function, and Evolution of Archaeo-Eukaryotic RNA Polymerases – Gatekeepers of the Genome
pp 78-92
- By Finn Werner, Dina Grohmann
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Chapter 6 - Single-Molecule Fluorescence Resonance Energy Transfer Investigations of Ribosome-Catalyzed Protein Synthesis
pp 93-116
- By Daniel D. MacDougall, Jingyi Fei, Ruben L. Gonzalez
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Chapter 7 - Structure and Dynamics of the Ribosome as Revealed by Cryo-Electron Microscopy
pp 117-141
- By Xabier Agirrezabala, Mikel Valle
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Chapter 8 - Viewing the Mechanisms of Translation through the Computational Microscope
pp 142-157
- By James Gumbart, Eduard Schreiner, Leonardo G. Trabuco, Kwok-Yan Chan, Klaus Schulten
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Chapter 9 - The Ribosome as a Brownian Ratchet Machine
pp 158-190
- By Alexander S. Spirin, Alexei V. Finkelstein
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Chapter 10 - The GroEL/GroES Chaperonin Machine
pp 191-207
- By Arthur L. Horwich, Helen R. Saibil
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Chapter 11 - ATP Synthase – A Paradigmatic Molecular Machine
pp 208-238
- By Thomas Meier, José D. Faraldo-Gómez, Michael Börsch
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Chapter 12 - ATP-Dependent Proteases: The Cell's Degradation Machines
pp 239-260
- By Sucharita Bhattacharyya, Shameika R. Wilmington, Andreas Matouschek
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Index
pp 261-272
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Molecular Machines in Biology

Workshop of the Cell

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Contents

Frontmatter
pp i-iv

Contents
pp v-vi

Contributors
pp vii-viii

Figures and Tables
pp ix-xii

Preface
pp xiii-xiv

Introduction
pp 1-3

Chapter 1 - Single-Molecule FRET: Technique and Applications to the Studies of Molecular Machines
pp 4-19

Chapter 2 - Visualization of Molecular Machines by Cryo-Electron Microscopy
pp 20-37

Chapter 3 - Statistical Mechanical Treatment of Molecular Machines
pp 38-58

Chapter 4 - Exploring the Functional Landscape of Biomolecular Machines via Elastic Network Normal Mode Analysis
pp 59-77

Chapter 5 - Structure, Function, and Evolution of Archaeo-Eukaryotic RNA Polymerases – Gatekeepers of the Genome
pp 78-92

Chapter 6 - Single-Molecule Fluorescence Resonance Energy Transfer Investigations of Ribosome-Catalyzed Protein Synthesis
pp 93-116

Chapter 7 - Structure and Dynamics of the Ribosome as Revealed by Cryo-Electron Microscopy
pp 117-141

Chapter 8 - Viewing the Mechanisms of Translation through the Computational Microscope
pp 142-157

Chapter 9 - The Ribosome as a Brownian Ratchet Machine
pp 158-190

Chapter 10 - The GroEL/GroES Chaperonin Machine
pp 191-207

Chapter 11 - ATP Synthase – A Paradigmatic Molecular Machine
pp 208-238

Chapter 12 - ATP-Dependent Proteases: The Cell's Degradation Machines
pp 239-260

Index
pp 261-272

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Molecular Machines in Biology

Workshop of the Cell

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