The polycystic ovary syndrome and adolescent women

doi:10.1017/CBO9780511527036.028

27 - The polycystic ovary syndrome and adolescent women

from Part III - Management of specific disorders

Published online by Cambridge University Press: 04 May 2010

Adam H. Balen and

Edited by

Jane MacDougall and

Adam H. Balen: Affiliation:
Department of Reproductive Medicine, The General Infirmary, Leeds, UK
David Dunger: Affiliation:
Department of Paediatrics, Addenbrooke's Hospital, Cambridge, UK
Adam H. Balen: Affiliation:
Leeds Teaching Hospitals, University Trust
Sarah M. Creighton: Affiliation:
University College London Hospitals
Melanie C. Davies: Affiliation:
University College London
Jane MacDougall: Affiliation:
Addenbrooke's Hospital, Cambridge
Richard Stanhope: Affiliation:
Great Ormond Street Hospital

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Summary

Introduction

The polycystic ovary syndrome (PCOS) is the commonest endocrine disturbance affecting women, yet it is only in the 1990s that we have begun to piece together a clearer idea of its pathogenesis (Balen, 1999). It has long been recognized that the presence of enlarged ovaries with multiple small cysts (2–9 mm) and a hypervascularized, androgen—secreting stroma are associated with signs of androgen excess (hirsutism, alopecia, acne), obesity and menstrual cycle disturbance (oligomenorrhoea or amenorrhoea). There is considerable heterogeneity of symptoms and signs amongst women with PCOS (Table 27.1) and for an individual these may change over time (Balen et al., 1995). The PCOS is familial (Franks et al., 1997) and various aspects of the syndrome may be differentially inherited. Furthermore, polycystic ovaries can exist without clinical signs of the syndrome, which may then become expressed over time. While ultrasound provides an excellent technique for the detection of polycystic ovaries, controversy still exists over the precise definition of PCOS and whether or not the diagnosis should require confirmation of polycystic ovarian morphology (Figs. 27.1–27.4).

Some argue that the definition of PCOS should be based on biochemical evidence of ovarian hyperandrogenism rather than the ultrasound appearance, as hyperandrogenism may exist in women who have normal ovarian morphology as detected by ultrasound. This view has been adopted in the USA and the 1990 National Institute of Health Conference on PCOS recommended that diagnostic criteria should include evidence of hyperandrogenism and ovulatory dysfunction in the absence of nonclassical adrenal hyperplasia and that evidence of polycystic ovarian morphology is not essential.

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Type: Chapter
Information: Paediatric and Adolescent Gynaecology
A Multidisciplinary Approach
, pp. 342 - 353

DOI: https://doi.org/10.1017/CBO9780511527036.028 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2004

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