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4 - Anaesthesia for the elderly

Published online by Cambridge University Press:  15 December 2009

Christopher Dodds
Affiliation:
Professor Cleveland School of Anaesthesia James Cook University Hospital Marton Road Middlesborough TS4 3BW UK
Jeremy Cashman
Affiliation:
St George's Hospital, London
Michael Grounds
Affiliation:
St George's Hospital, London
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Summary

The care of the elderly patient during anaesthesia is one of the most common tasks we perform. It has the highest rate of serious complications and long-term effects and yet it is also the least researched and taught element of anaesthetic practice. The absolute number of the elderly and their relative proportion in our population are increasing and will do so until the latter part of the century. This has an impact not only on the challenges to our anaesthetic practice, but also, because of the reduction in the proportion of people paying taxes, in the country's ability to pay for healthcare. Increased disability and dependence on other carers greatly add to this burden. The figure of a 25% incidence of cognitive dysfunction following major surgery would cause political intervention in any other group of patients. There have been some advances in our understanding of the elderly, in the availability of newer drugs and techniques for instance, that make a review worthwhile.

The basics of getting old

The research into aging and the cellular process underlying these are advancing rapidly in many areas. Integrating these into the responses we observe is more difficult, largely because getting older is a combination of aging at a cellular, organ and systems level with the residual impact of acute and chronic disease states, and finally the adaptation of life-style the patient uses to cope as long as possible. It is this behavioural adaptation that masks many of the underlying processes of importance to us.

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Publisher: Cambridge University Press
Print publication year: 2007

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References

Rasmussen, LS, Johnson, T, Kuipers, HM, et al. ISPOCD2 (International Study of Postoperative Cognitive Dysfunction) Investigators. Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients. Acta Anaesthesiol Scand 2003; 47: 260–6.CrossRefGoogle ScholarPubMed
Wright, WE, Shay, JW. Telomere biology in aging and cancer. J Am Geriatr Soc 2005; 53(9 Suppl.): S292–S4.CrossRefGoogle ScholarPubMed
Conboy, IM, Conboy, MJ, Wagers, AJ, et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005; 433: 760–4.CrossRefGoogle ScholarPubMed
Aldskogius, H, Kozlova, EN. Central neuron–glial and glial–glial interactions following axon injury. Progress Neurobiol 1998; 55: 1–26.CrossRefGoogle ScholarPubMed
Griffin, WS. Inflammation and neurodegenerative diseases. Am J Clin Nutr 2006; 83: 470S–4S.CrossRefGoogle ScholarPubMed
Acarin, L, Paris, J, Gonzalez, B, Castellano, B. Glial expression of small heat shock proteins following an excitotoxic lesion in the immature rat brain. Glia 2002; 38: 1–14.CrossRefGoogle ScholarPubMed
Abildstrom, H, Christiansen, M, Siersma, VD, Rasmussen, LS. Apolipoprotein E genotype and cognitive dysfunction after noncardiac surgery. Anesthesiology 2004; 101: 855–61.CrossRefGoogle ScholarPubMed
Philbin, EF, Ries, MD, French, TS. Feasibility of maximal cardiopulmonary exercise testing in patients with end-stage arthritis of the hip and knee prior to total joint arthroplasty. Chest 1995; 108: 174–81.CrossRefGoogle ScholarPubMed
Kennedy, JM, Rij, AM, Spears, GFet al. Polypharmacy in a general surgical unit and consequences of drug withdrawal. Br J Clin Pharm 2000; 49: 353–62.CrossRefGoogle Scholar
Ades, PA, Waldmann, ML, Poehlman, ETet al. Exercise conditioning in older coronary patients. Submaximal lactate response and endurance capacity. Circulation 1993; 88: 572–7.CrossRefGoogle ScholarPubMed
Ehsani, AA, Spina, RJ, Peterson, LRet al. Attenuation of cardiovascular adaptations to exercise in frail octogenarians. J Appl Physiol 2003; 95: 1781–8.CrossRefGoogle ScholarPubMed
Rockwood, K, Mtinski, AB, MacKnight, C. Some mathematical models of frailty and their clinical implications. Age Ageing 2004; 33: 430–2.Google Scholar
Cope, TM, Hunter, JM. Selecting neuromuscular-blocking drugs for elderly patients. Drugs Ageing 2003; 20: 125–40.CrossRefGoogle ScholarPubMed
Bennett, JA, Lingaraju, N, Horrow, JC, McElrath, T, Keykhah, MM. Elderly patients recover more rapidly from desflurane than from isoflurane anesthesia. J Clin Anesth 1992; 4: 378–81.CrossRefGoogle ScholarPubMed
NSF for Older People: Medicines and Older People Appendix. London: DoH; 2001; available at: http://www.dh.gov.uk/assetRoot/04/06/72/47/04067247.pdf.
Briggs, M, Closs, JS. A descriptive study of the use of visual analogue scales and verbal rating scales for the assessment of postoperative pain in orthopedic patients. J Pain Symptom Managem 1999; 18: 438–46.CrossRefGoogle ScholarPubMed
Lipowski, ZJ. Delirium (acute confusional states). JAMA 1987; 258: 1789–92.CrossRefGoogle Scholar
Lipowski, ZJ. Delirium in the elderly patient. N Engl J Med 1989; 320: 578–82.Google ScholarPubMed
Naughton, BJ, Moran, MB, Kadah, H, Heman-Ackah, Y, Longano, J.Delirium and other cognitive impairments in older adults in an emergency department. Ann Emerg Med 1995; 25: 751–5.CrossRefGoogle Scholar
Inouye, SK. Delirium in hospitalized older patients. Clin Geriatr Med 1998; 14: 745–64.Google ScholarPubMed
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th edn. Washington DC: American Psychiatric Association, 1994.
Bedford, PD. Adverse cerebral effects of anaesthesia on old people. Lancet 1955; 269: 259–63.CrossRefGoogle ScholarPubMed
Jevtovic-Todorovic, V, Carter, LB. The anesthetics nitrous oxide and ketamine are more neurotoxic to old than to young rat brain. Neurobiol Aging 2005; 26: 947–56.CrossRefGoogle ScholarPubMed
Butterfield, NN, Graf, P, Ries, CR, MacLeod, BA. The effect of repeated isoflurane anesthesia on spatial and psychomotor performance in young and aged mice. Anesth Analg 2004; 98: 1305–11.CrossRefGoogle Scholar
Shinozaki, M, Usui, Y, Yamaguchi, S, Okuda, Y, Kitajima, T. Recovery of psychomotor function after propofol sedation is prolonged in the elderly. Can J Anaesth 2002; 49: 927–31.CrossRefGoogle ScholarPubMed

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