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14 - Theileria: life cycle stages associated with the ixodid tick vector

Published online by Cambridge University Press:  21 August 2009

By
R. Bishop ,
A. Musoke ,
R. Skilton ,
S. Morzaria ,
M. Gardner  and
V. Nene
Edited by
Alan S. Bowman  and
Patricia A. Nuttall
R. Bishop
Affiliation:
International Livestock Research Institute (ILRI) P.O. Box 30709 Nairobi 00100 Kenya
A. Musoke
Affiliation:
Onderstepoort Veterinary Institute Private Bag X5 Onderstepoort 0110 South Africa
R. Skilton
Affiliation:
International Livestock Research Institute (ILRI) P.O. Box 30709 Nairobi 00100 Kenya
S. Morzaria
Affiliation:
Food and Agriculture Organization (FAO) 39 Phra Atit Road Bangkok 10200 Thailand
M. Gardner
Affiliation:
Seattle Biomedical Research Institute 307 Westlake Ave. N. Suite 500 Seattle WA 98109 USA
V. Nene
Affiliation:
The Institute for Genomic Research (TIGR) 9712 Medical Center Drive Rockville MD 20850 USA
Alan S. Bowman
Affiliation:
University of Aberdeen
Patricia A. Nuttall
Affiliation:
Centre for Ecology and Hydrology, Swindon
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Summary

INTRODUCTION

The genus Theileria comprises tick-transmitted sporozoan protozoa that are the causative agents of a variety of disease syndromes in domestic and wild ruminants, and are collectively responsible for economic losses amounting to hundreds of millions of dollars annually in sub-Saharan Africa and Asia. Theileria are unique among protozoa, in that certain species are capable of immortalizing either mammalian lymphocytes, or cells of the monocyte/macrophage lineage that they infect. Theileria has been included within a subphylum designated the Apicomplexa, based on the common possession of an apical complex containing secretory organelles involved in invasion, or establishment, in the cells of their mammalian and invertebrate hosts. However the evolutionary and functional equivalence of the apical complex between different genera and hence the taxonomic validity of the Apicomplexa remains unclear. Analysis of 18S ribosomal RNA gene sequences demonstrates that the genus Theileria is phylogenetically most closely related to Babesia, a genus of tick-borne protozoan infective to the red cells of mammals including domestic livestock, and more distantly to the genus Plasmodium which causes malaria in humans and other species of vertebrates (Allsopp et al., 1994). There are similarities, but also significant differences, in features of the life cycle, genome organization and mammalian host immune responses to infection between Theileria and Plasmodium.

Economically important Theileria species that infect cattle and small ruminants are transmitted by ixodid ticks of the genera Rhipicephalus, Amblyomma, Hyalomma and Haemaphysalis. Theileria species infective to domestic ruminants are summarized in Table 14.1.

Type
Chapter
Information
Ticks
Biology, Disease and Control
 , pp. 308 - 324
Publisher: Cambridge University Press
Print publication year: 2008

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  • Theileria: life cycle stages associated with the ixodid tick vector
    • By R. Bishop, International Livestock Research Institute (ILRI) P.O. Box 30709 Nairobi 00100 Kenya, A. Musoke, Onderstepoort Veterinary Institute Private Bag X5 Onderstepoort 0110 South Africa, R. Skilton, International Livestock Research Institute (ILRI) P.O. Box 30709 Nairobi 00100 Kenya, S. Morzaria, Food and Agriculture Organization (FAO) 39 Phra Atit Road Bangkok 10200 Thailand, M. Gardner, Seattle Biomedical Research Institute 307 Westlake Ave. N. Suite 500 Seattle WA 98109 USA, V. Nene, The Institute for Genomic Research (TIGR) 9712 Medical Center Drive Rockville MD 20850 USA
  • Edited by Alan S. Bowman, University of Aberdeen, Patricia A. Nuttall
  • Book: Ticks
  • Online publication: 21 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511551802.015
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  • Theileria: life cycle stages associated with the ixodid tick vector
    • By R. Bishop, International Livestock Research Institute (ILRI) P.O. Box 30709 Nairobi 00100 Kenya, A. Musoke, Onderstepoort Veterinary Institute Private Bag X5 Onderstepoort 0110 South Africa, R. Skilton, International Livestock Research Institute (ILRI) P.O. Box 30709 Nairobi 00100 Kenya, S. Morzaria, Food and Agriculture Organization (FAO) 39 Phra Atit Road Bangkok 10200 Thailand, M. Gardner, Seattle Biomedical Research Institute 307 Westlake Ave. N. Suite 500 Seattle WA 98109 USA, V. Nene, The Institute for Genomic Research (TIGR) 9712 Medical Center Drive Rockville MD 20850 USA
  • Edited by Alan S. Bowman, University of Aberdeen, Patricia A. Nuttall
  • Book: Ticks
  • Online publication: 21 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511551802.015
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  • Theileria: life cycle stages associated with the ixodid tick vector
    • By R. Bishop, International Livestock Research Institute (ILRI) P.O. Box 30709 Nairobi 00100 Kenya, A. Musoke, Onderstepoort Veterinary Institute Private Bag X5 Onderstepoort 0110 South Africa, R. Skilton, International Livestock Research Institute (ILRI) P.O. Box 30709 Nairobi 00100 Kenya, S. Morzaria, Food and Agriculture Organization (FAO) 39 Phra Atit Road Bangkok 10200 Thailand, M. Gardner, Seattle Biomedical Research Institute 307 Westlake Ave. N. Suite 500 Seattle WA 98109 USA, V. Nene, The Institute for Genomic Research (TIGR) 9712 Medical Center Drive Rockville MD 20850 USA
  • Edited by Alan S. Bowman, University of Aberdeen, Patricia A. Nuttall
  • Book: Ticks
  • Online publication: 21 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511551802.015
Available formats
×